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Mar Drugs
2019 Aug 01;178:. doi: 10.3390/md17080455.
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Long-Chain Bases from Sea Cucumber Alleviate Obesity by Modulating Gut Microbiota.
Hu S
,
Xu Y
,
Gao X
,
Li S
,
Jiang W
,
Liu Y
,
Su L
,
Yang H
.
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This study evaluated the effects of long-chain bases from sea cucumber (SC-LCBs) on modulation of the gut microbiota and inhibition of obesity in high fat diet-fed mice. Results showed that SC-LCBs exerted significant antiobese effects, which were associated with the inhibition of hyperglycemia and lipid accumulation. SC-LCBs also regulated serum adipocytokines toward to normal levels. SC-LCBs caused significant decreases in Firmicutes, Actinobacteria phylum, and obesity-related bacteria (Desulfovibro, Bifidobacterium, Romboutsia etc. genus). SC-LCBs also elevated Bacteroidetes, Proteobacteria, Verrucomicrobia phylum, and short chain fatty acids (SCFAs)-producing bacteria (Bacteroides, Lactobacillus, Lachnospiraceae_NK4A136_group etc. genus). Moreover, serum and fecal lipoplysaccharide (LPS) concentrations and its dependent toll-line receptor 4 pathway were inhibited by SC-LCBs treatment. SC-LCBs caused increases in fecal SCFAs and their mediated G-protein-coupled receptors proteins. These suggest that SC-LCBs alleviate obesity by altering gut microbiota. Thus, it sought to indicate that SC-LCBs can be developed as food supplement for the obesity control and the human gut health.
Figure 4. Effects of SC-LCBs on gut microbiota at class and order levels using ternaryplot method (n = 5). (A), gut microbiota at class level; (B), gut microbiota at order level.
Figure 5. Response of gut microbiota at the genus level to SC-LCBs treatment (n = 5). The heatmap is colour-coded based on row Z-scores. (A), heatmap indicating relative contribution of the top 50 dominat genera in each sample; (B), heatmap in each group.
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