Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Echinobase
ECB-ART-46940
Carbohydr Polym 2019 Apr 01;209:363-371. doi: 10.1016/j.carbpol.2019.01.044.
Show Gene links Show Anatomy links

Structural characterization and in vitro hypoglycemic activity of a glucan from Euryale ferox Salisb. seeds.

Zhang WN , Su RN , Gong LL , Yang WW , Chen J , Yang R , Wang Y , Pan WJ , Lu YM , Chen Y .


???displayArticle.abstract???
In this research, a polysaccharide fraction (EFSP-1) was obtained from the seeds of Euryale ferox Salisb. by DEAE sepharose FF and Superdex™ 75 gel chromatography. The average molecular weight (Mw) of EFSP-1 was 8.75 kDa. Monosaccharides composition analysis indicated that EFSP-1 was a glucan. The structure of EFSP-1 was characterized by analysis of FT-IR, GC-MS and NMR, which indicated that the backbone of EFSP-1 was mainly composed of (1→4)-α-D-Glcp with branches substituted at O-6 and terminated with T-α-D-Glcp. Moreover, the hypoglycemic effect of EFSP-1 was investigated by establishing insulin resistance HepG2 and 3T3-L1 cells. The results showed that EFSP-1 could increase glucose consumption by up-regulating the expression of GLUT-4 via activating PI3K/Akt signal pathway in IR cells. Hence, EFSP-1 could be a potential functional food to ameliorate insulin resistance for diabetes therapy.

???displayArticle.pubmedLink??? 30732819
???displayArticle.link??? Carbohydr Polym


Genes referenced: LOC582192 LOC586734 LOC588766