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Echinobase
ECB-ART-46744
Development November 9, 2018; 145 (21):
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Neurogenesis in the sea urchin embryo is initiated uniquely in three domains.

McClay DR , Miranda E , Feinberg SL .


Abstract
Many marine larvae begin feeding within a day of fertilization, thus requiring rapid development of a nervous system to coordinate feeding activities. Here, we examine the patterning and specification of early neurogenesis in sea urchin embryos. Lineage analysis indicates that neurons arise locally in three regions of the embryo. Perturbation analyses showed that when patterning is disrupted, neurogenesis in the three regions is differentially affected, indicating distinct patterning requirements for each neural domain. Six transcription factors that function during proneural specification were identified and studied in detail. Perturbations of these proneural transcription factors showed that specification occurs differently in each neural domain prior to the Delta-Notch restriction signal. Though gene regulatory network state changes beyond the proneural restriction are largely unresolved, the data here show that the three neural regions already differ from each other significantly early in specification. Future studies that define the larval nervous system in the sea urchin must therefore separately characterize the three populations of neurons that enable the larva to feed, to navigate, and to move food particles through the gut.

PubMed ID: 30413529
PMC ID: PMC6240313
Article link: Development


Genes referenced: LOC100887844 LOC115921237
Morpholinos: bmp2 MO1 chrd MO1 dll1 MO3 fgf MO1 gemin2 MO1 lefty1 MO3 nodall MO2 six6 MO3 sox2 MO1 sox4 MO4 sox4 MO5 wnt6 MO2

References [+] :
Angerer, Patterning the sea urchin embryo: gene regulatory networks, signaling pathways, and cellular interactions. 2003, Pubmed, Echinobase