ECB-ART-46632
Genesis
2018 Oct 01;5610:e23253. doi: 10.1002/dvg.23253.
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From genome to anatomy: The architecture and evolution of the skeletogenic gene regulatory network of sea urchins and other echinoderms.
Shashikant T
,
Khor JM
,
Ettensohn CA
.
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The skeletogenic gene regulatory network (GRN) of sea urchins and other echinoderms is one of the most intensively studied transcriptional networks in any developing organism. As such, it serves as a preeminent model of GRN architecture and evolution. This review summarizes our current understanding of this developmental network. We describe in detail the most comprehensive model of the skeletogenic GRN, one developed for the euechinoid sea urchin Strongylocentrotus purpuratus, including its initial deployment by maternal inputs, its elaboration and stabilization through regulatory gene interactions, and its control of downstream effector genes that directly drive skeletal morphogenesis. We highlight recent comparative studies that have leveraged the euechinoid GRN model to examine the evolution of skeletogenic programs in diverse echinoderms, studies that have revealed both conserved and divergent features of skeletogenesis within the phylum. Last, we summarize the major insights that have emerged from analysis of the structure and evolution of the echinoderm skeletogenic GRN and identify key, unresolved questions as a guide for future work.
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Genes referenced: LOC100887844 LOC575170
References [+] :
Adams,
Rapid adaptation to food availability by a dopamine-mediated morphogenetic response.
2011, Pubmed,
Echinobase
Adams, Rapid adaptation to food availability by a dopamine-mediated morphogenetic response. 2011, Pubmed , Echinobase
Adomako-Ankomah, P58-A and P58-B: novel proteins that mediate skeletogenesis in the sea urchin embryo. 2011, Pubmed , Echinobase
Adomako-Ankomah, Growth factor-mediated mesodermal cell guidance and skeletogenesis during sea urchin gastrulation. 2013, Pubmed , Echinobase
Adomako-Ankomah, Growth factors and early mesoderm morphogenesis: insights from the sea urchin embryo. 2014, Pubmed , Echinobase
Akasaka, Genomic organization of a gene encoding the spicule matrix protein SM30 in the sea urchin Strongylocentrotus purpuratus. 1994, Pubmed , Echinobase
Amore, cis-Regulatory control of cyclophilin, a member of the ETS-DRI skeletogenic gene battery in the sea urchin embryo. 2006, Pubmed , Echinobase
Andrey, The three-dimensional genome: regulating gene expression during pluripotency and development. 2017, Pubmed
Arnone, Echinoderm systems for gene regulatory studies in evolution and development. 2016, Pubmed , Echinobase
Barsi, Genome-wide assessment of differential effector gene use in embryogenesis. 2015, Pubmed , Echinobase
Barsi, General approach for in vivo recovery of cell type-specific effector gene sets. 2014, Pubmed , Echinobase
Ben-Tabou de-Leon, Experimentally based sea urchin gene regulatory network and the causal explanation of developmental phenomenology. 2009, Pubmed , Echinobase
Bienz, Signalosome assembly by domains undergoing dynamic head-to-tail polymerization. 2014, Pubmed
Cameron, Biomineral ultrastructure, elemental constitution and genomic analysis of biomineralization-related proteins in hemichordates. 2012, Pubmed , Echinobase
Cannon, Phylogenomic resolution of the hemichordate and echinoderm clade. 2014, Pubmed , Echinobase
Cary, Echinoderm development and evolution in the post-genomic era. 2017, Pubmed , Echinobase
Cary, Genome-wide use of high- and low-affinity Tbrain transcription factor binding sites during echinoderm development. 2017, Pubmed , Echinobase
Cheatle Jarvela, Modular evolution of DNA-binding preference of a Tbrain transcription factor provides a mechanism for modifying gene regulatory networks. 2014, Pubmed , Echinobase
Cheers, P16 is an essential regulator of skeletogenesis in the sea urchin embryo. 2005, Pubmed , Echinobase
Chuang, Transient appearance of Strongylocentrotus purpuratus Otx in micromere nuclei: cytoplasmic retention of SpOtx possibly mediated through an alpha-actinin interaction. 1996, Pubmed , Echinobase
Croce, ske-T, a T-box gene expressed in the skeletogenic mesenchyme lineage of the sea urchin embryo. 2001, Pubmed , Echinobase
Czarkwiani, Expression of skeletogenic genes during arm regeneration in the brittle star Amphiura filiformis. 2013, Pubmed , Echinobase
Damle, Precise cis-regulatory control of spatial and temporal expression of the alx-1 gene in the skeletogenic lineage of s. purpuratus. 2011, Pubmed , Echinobase
Dan, Attachment of one spindle pole to the cortex in unequal cleavage. 1990, Pubmed , Echinobase
Davidson, Gene regulatory networks and the evolution of animal body plans. 2006, Pubmed
Davidson, Specification of cell fate in the sea urchin embryo: summary and some proposed mechanisms. 1998, Pubmed , Echinobase
Davidson, A genomic regulatory network for development. 2002, Pubmed , Echinobase
Duloquin, Localized VEGF signaling from ectoderm to mesenchyme cells controls morphogenesis of the sea urchin embryo skeleton. 2007, Pubmed , Echinobase
Dylus, Large-scale gene expression study in the ophiuroid Amphiura filiformis provides insights into evolution of gene regulatory networks. 2016, Pubmed , Echinobase
Dylus, Developmental transcriptomics of the brittle star Amphiura filiformis reveals gene regulatory network rewiring in echinoderm larval skeleton evolution. 2018, Pubmed , Echinobase
Emlet, Larval Form and Metamorphosis of a "Primitive" Sea Urchin, Eucidaris thouarsi (Echinodermata: Echinoidea: Cidaroida), with Implications for Developmental and Phylogenetic Studies. 1988, Pubmed , Echinobase
Emlet, Crystal axes in recent and fossil adult echinoids indicate trophic mode in larval development. 1985, Pubmed , Echinobase
Erkenbrack, Evolutionary rewiring of gene regulatory network linkages at divergence of the echinoid subclasses. 2015, Pubmed , Echinobase
Erkenbrack, A Conserved Role for VEGF Signaling in Specification of Homologous Mesenchymal Cell Types Positioned at Spatially Distinct Developmental Addresses in Early Development of Sea Urchins. 2017, Pubmed , Echinobase
Erwin, The Cambrian conundrum: early divergence and later ecological success in the early history of animals. 2011, Pubmed
Ettensohn, Lessons from a gene regulatory network: echinoderm skeletogenesis provides insights into evolution, plasticity and morphogenesis. 2009, Pubmed , Echinobase
Ettensohn, The emergence of pattern in embryogenesis: regulation of beta-catenin localization during early sea urchin development. 2006, Pubmed , Echinobase
Ettensohn, Gene regulatory networks and developmental plasticity in the early sea urchin embryo: alternative deployment of the skeletogenic gene regulatory network. 2007, Pubmed , Echinobase
Ettensohn, Alx1, a member of the Cart1/Alx3/Alx4 subfamily of Paired-class homeodomain proteins, is an essential component of the gene network controlling skeletogenic fate specification in the sea urchin embryo. 2003, Pubmed , Echinobase
Ettensohn, Horizontal transfer of the msp130 gene supported the evolution of metazoan biomineralization. 2014, Pubmed , Echinobase
Ettensohn, KirrelL, a member of the Ig-domain superfamily of adhesion proteins, is essential for fusion of primary mesenchyme cells in the sea urchin embryo. 2017, Pubmed , Echinobase
Ettensohn, Encoding anatomy: developmental gene regulatory networks and morphogenesis. 2013, Pubmed , Echinobase
Fernandez-Serra, Role of the ERK-mediated signaling pathway in mesenchyme formation and differentiation in the sea urchin embryo. 2004, Pubmed , Echinobase
Flores, The skeletal proteome of the sea star Patiria miniata and evolution of biomineralization in echinoderms. 2017, Pubmed , Echinobase
Flynn, High-resolution, three-dimensional mapping of gene expression using GeneExpressMap (GEM). 2011, Pubmed , Echinobase
Frudakis, Two cis elements collaborate to spatially repress transcription from a sea urchin promoter. 1995, Pubmed , Echinobase
Fuchikami, T-brain homologue (HpTb) is involved in the archenteron induction signals of micromere descendant cells in the sea urchin embryo. 2002, Pubmed , Echinobase
Fujita, HpSulf, a heparan sulfate 6-O-endosulfatase, is involved in the regulation of VEGF signaling during sea urchin development. 2010, Pubmed , Echinobase
Gao, Transfer of a large gene regulatory apparatus to a new developmental address in echinoid evolution. 2008, Pubmed , Echinobase
Gao, Juvenile skeletogenesis in anciently diverged sea urchin clades. 2015, Pubmed , Echinobase
Garfield, The impact of gene expression variation on the robustness and evolvability of a developmental gene regulatory network. 2013, Pubmed , Echinobase
Gong, Phase transitions in biogenic amorphous calcium carbonate. 2012, Pubmed , Echinobase
Gross, LvTbx2/3: a T-box family transcription factor involved in formation of the oral/aboral axis of the sea urchin embryo. 2003, Pubmed , Echinobase
Guss, Skeletal morphogenesis in the sea urchin embryo: regulation of primary mesenchyme gene expression and skeletal rod growth by ectoderm-derived cues. 1997, Pubmed , Echinobase
Halfon, Perspectives on Gene Regulatory Network Evolution. 2017, Pubmed
Harkey, Differential expression of the msp130 gene among skeletal lineage cells in the sea urchin embryo: a three dimensional in situ hybridization analysis. 1992, Pubmed , Echinobase
Harkey, Structure, expression, and extracellular targeting of PM27, a skeletal protein associated specifically with growth of the sea urchin larval spicule. 1995, Pubmed , Echinobase
Hart, Functional Consequences of Phenotypic Plasticity in Echinoid Larvae. 1994, Pubmed , Echinobase
Hinman, Caught in the evolutionary act: precise cis-regulatory basis of difference in the organization of gene networks of sea stars and sea urchins. 2007, Pubmed , Echinobase
Hodor, The dynamics and regulation of mesenchymal cell fusion in the sea urchin embryo. 1998, Pubmed , Echinobase
Holy, Differential behavior of centrosomes in unequally dividing blastomeres during fourth cleavage of sea urchin embryos. 1991, Pubmed , Echinobase
Huang, Involvement of Tcf/Lef in establishing cell types along the animal-vegetal axis of sea urchins. 2000, Pubmed , Echinobase
Illies, Identification and developmental expression of new biomineralization proteins in the sea urchin Strongylocentrotus purpuratus. 2002, Pubmed , Echinobase
Ingersoll, Matrix metalloproteinase inhibitors disrupt spicule formation by primary mesenchyme cells in the sea urchin embryo. 1998, Pubmed , Echinobase
Israel, Comparative Developmental Transcriptomics Reveals Rewiring of a Highly Conserved Gene Regulatory Network during a Major Life History Switch in the Sea Urchin Genus Heliocidaris. 2016, Pubmed , Echinobase
Johnson, Genome-wide mapping of in vivo protein-DNA interactions. 2007, Pubmed
Khor, Functional divergence of paralogous transcription factors supported the evolution of biomineralization in echinoderms. 2017, Pubmed , Echinobase
Killian, Molecular aspects of biomineralization of the echinoderm endoskeleton. 2008, Pubmed , Echinobase
Killian, Endocytosis in primary mesenchyme cells during sea urchin larval skeletogenesis. 2017, Pubmed , Echinobase
Kitamura, Transient activation of the micro1 homeobox gene family in the sea urchin ( Hemicentrotus pulcherrimus) micromere. 2002, Pubmed , Echinobase
Knapp, Recombinant sea urchin vascular endothelial growth factor directs single-crystal growth and branching in vitro. 2012, Pubmed , Echinobase
Kniprath, Ultrastructure and growth of the sea urchin tooth. 1974, Pubmed , Echinobase
Koga, The echinoderm larval skeleton as a possible model system for experimental evolutionary biology. 2014, Pubmed , Echinobase
Koga, Functional evolution of Ets in echinoderms with focus on the evolution of echinoderm larval skeletons. 2010, Pubmed , Echinobase
Koga, Experimental Approach Reveals the Role of alx1 in the Evolution of the Echinoderm Larval Skeleton. 2016, Pubmed , Echinobase
Kominami, Unequal divisions at the third cleavage increase the number of primary mesenchyme cells in sea urchin embryos. 1998, Pubmed , Echinobase
Kurokawa, HpEts, an ets-related transcription factor implicated in primary mesenchyme cell differentiation in the sea urchin embryo. 1999, Pubmed , Echinobase
Langelan, Unequal cleavage and the differentiation of echinoid primary mesenchyme. 1985, Pubmed , Echinobase
Leonard, Analysis of dishevelled localization and function in the early sea urchin embryo. 2007, Pubmed , Echinobase
Levine, Gene regulatory networks for development. 2005, Pubmed , Echinobase
Li, Two Otx proteins generated from multiple transcripts of a single gene in Strongylocentrotus purpuratus. 1997, Pubmed , Echinobase
Livingston, A genome-wide analysis of biomineralization-related proteins in the sea urchin Strongylocentrotus purpuratus. 2006, Pubmed , Echinobase
Logan, Nuclear beta-catenin is required to specify vegetal cell fates in the sea urchin embryo. 1999, Pubmed , Echinobase
Lynch, Resurrecting the role of transcription factor change in developmental evolution. 2008, Pubmed
Lyons, Morphogenesis in sea urchin embryos: linking cellular events to gene regulatory network states. 2012, Pubmed , Echinobase
Makabe, Cis-regulatory control of the SM50 gene, an early marker of skeletogenic lineage specification in the sea urchin embryo. 1995, Pubmed , Echinobase
Mann, Proteomic analysis of sea urchin (Strongylocentrotus purpuratus) spicule matrix. 2010, Pubmed , Echinobase
Mann, In-depth, high-accuracy proteomics of sea urchin tooth organic matrix. 2008, Pubmed , Echinobase
Mann, The sea urchin (Strongylocentrotus purpuratus) test and spine proteomes. 2008, Pubmed , Echinobase
Martik, Developmental gene regulatory networks in sea urchins and what we can learn from them. 2016, Pubmed , Echinobase
Materna, High accuracy, high-resolution prevalence measurement for the majority of locally expressed regulatory genes in early sea urchin development. 2010, Pubmed , Echinobase
Materna, A comprehensive analysis of Delta signaling in pre-gastrular sea urchin embryos. 2012, Pubmed , Echinobase
McCauley, Development of an embryonic skeletogenic mesenchyme lineage in a sea cucumber reveals the trajectory of change for the evolution of novel structures in echinoderms. 2012, Pubmed , Echinobase
McCauley, A conserved gene regulatory network subcircuit drives different developmental fates in the vegetal pole of highly divergent echinoderm embryos. 2010, Pubmed , Echinobase
McIntyre, Branching out: origins of the sea urchin larval skeleton in development and evolution. 2014, Pubmed , Echinobase
Mellott, Notch signaling patterns neurogenic ectoderm and regulates the asymmetric division of neural progenitors in sea urchin embryos. 2017, Pubmed , Echinobase
Miller, Molecular phylogeny of extant Holothuroidea (Echinodermata). 2017, Pubmed , Echinobase
Minokawa, cis-Regulatory inputs of the wnt8 gene in the sea urchin endomesoderm network. 2005, Pubmed , Echinobase
Mitsunaga, Carbonic anhydrase activity in developing sea urchin embryos with special reference to calcification of spicules. 1986, Pubmed , Echinobase
Morino, The conserved genetic background for pluteus arm development in brittle stars and sea urchin. 2016, Pubmed , Echinobase
Morino, Heterochronic activation of VEGF signaling and the evolution of the skeleton in echinoderm pluteus larvae. 2012, Pubmed , Echinobase
Nam, Barcoded DNA-tag reporters for multiplex cis-regulatory analysis. 2012, Pubmed , Echinobase
Nishimura, Structure, regulation, and function of micro1 in the sea urchin Hemicentrotus pulcherrimus. 2004, Pubmed , Echinobase
Oliveri, Activation of pmar1 controls specification of micromeres in the sea urchin embryo. 2003, Pubmed , Echinobase
Oliveri, A regulatory gene network that directs micromere specification in the sea urchin embryo. 2002, Pubmed , Echinobase
Oliveri, Global regulatory logic for specification of an embryonic cell lineage. 2008, Pubmed , Echinobase
Otim, An empirical model of Onecut binding activity at the sea urchin SM50 C-element gene regulatory region. 2017, Pubmed , Echinobase
Oulhen, Transient translational quiescence in primordial germ cells. 2017, Pubmed , Echinobase
Page, Analysis of competence in cultured sea urchin micromeres. 1992, Pubmed , Echinobase
Peng, Differential regulation of disheveled in a novel vegetal cortical domain in sea urchin eggs and embryos: implications for the localized activation of canonical Wnt signaling. 2013, Pubmed , Echinobase
Pennington, Consequences of the Calcite Skeletons of Planktonic Echinoderm Larvae for Orientation, Swimming, and Shape. 1990, Pubmed
Peter, Regulatory states in the developmental control of gene expression. 2017, Pubmed , Echinobase
Piacentino, Late Alk4/5/7 signaling is required for anterior skeletal patterning in sea urchin embryos. 2015, Pubmed , Echinobase
Piacentino, RNA-Seq identifies SPGs as a ventral skeletal patterning cue in sea urchins. 2016, Pubmed , Echinobase
Raff, Constraint, flexibility, and phylogenetic history in the evolution of direct development in sea urchins. 1987, Pubmed , Echinobase
Rafiq, Genome-wide analysis of the skeletogenic gene regulatory network of sea urchins. 2014, Pubmed , Echinobase
Rafiq, The genomic regulatory control of skeletal morphogenesis in the sea urchin. 2012, Pubmed , Echinobase
Rebeiz, Unraveling the Tangled Skein: The Evolution of Transcriptional Regulatory Networks in Development. 2015, Pubmed
Reich, Phylogenomic analyses of Echinodermata support the sister groups of Asterozoa and Echinozoa. 2015, Pubmed , Echinobase
Revilla-i-Domingo, R11: a cis-regulatory node of the sea urchin embryo gene network that controls early expression of SpDelta in micromeres. 2004, Pubmed , Echinobase
Revilla-i-Domingo, A missing link in the sea urchin embryo gene regulatory network: hesC and the double-negative specification of micromeres. 2007, Pubmed , Echinobase
Rho, The control of foxN2/3 expression in sea urchin embryos and its function in the skeletogenic gene regulatory network. 2011, Pubmed , Echinobase
Rizzo, Identification and developmental expression of the ets gene family in the sea urchin (Strongylocentrotus purpuratus). 2006, Pubmed , Echinobase
Roe, Inhibitors of metalloendoproteases block spiculogenesis in sea urchin primary mesenchyme cells. 1989, Pubmed , Echinobase
Ruffins, A fate map of the vegetal plate of the sea urchin (Lytechinus variegatus) mesenchyme blastula. 1996, Pubmed , Echinobase
Röttinger, A Raf/MEK/ERK signaling pathway is required for development of the sea urchin embryo micromere lineage through phosphorylation of the transcription factor Ets. 2004, Pubmed , Echinobase
Röttinger, FGF signals guide migration of mesenchymal cells, control skeletal morphogenesis [corrected] and regulate gastrulation during sea urchin development. 2008, Pubmed , Echinobase
Schroeder, Fourth cleavage of sea urchin blastomeres: microtubule patterns and myosin localization in equal and unequal cell divisions. 1987, Pubmed , Echinobase
Seaver, Examination of the skeletal proteome of the brittle star Ophiocoma wendtii reveals overall conservation of proteins but variation in spicule matrix proteins. 2015, Pubmed , Echinobase
Sharma, Activation of the skeletogenic gene regulatory network in the early sea urchin embryo. 2010, Pubmed , Echinobase
Shashikant, Global analysis of primary mesenchyme cell cis-regulatory modules by chromatin accessibility profiling. 2018, Pubmed , Echinobase
Smith, A gene regulatory network subcircuit drives a dynamic pattern of gene expression. 2007, Pubmed , Echinobase
Smith, A protocol describing the principles of cis-regulatory analysis in the sea urchin. 2008, Pubmed , Echinobase
Smith, Gene regulatory network subcircuit controlling a dynamic spatial pattern of signaling in the sea urchin embryo. 2008, Pubmed , Echinobase
Spitz, Transcription factors: from enhancer binding to developmental control. 2012, Pubmed
Stock, Sea urchins have teeth? A review of their microstructure, biomineralization, development and mechanical properties. 2014, Pubmed , Echinobase
Strathmann, Good eaters, poor swimmers: compromises in larval form. 2006, Pubmed , Echinobase
Summerton, Morpholino antisense oligomers: design, preparation, and properties. 1997, Pubmed
Sun, Signal-dependent regulation of the sea urchin skeletogenic gene regulatory network. 2014, Pubmed , Echinobase
Sun, TGF-β sensu stricto signaling regulates skeletal morphogenesis in the sea urchin embryo. 2017, Pubmed , Echinobase
Swartz, Deadenylase depletion protects inherited mRNAs in primordial germ cells. 2014, Pubmed , Echinobase
Sweet, LvDelta is a mesoderm-inducing signal in the sea urchin embryo and can endow blastomeres with organizer-like properties. 2002, Pubmed , Echinobase
Szabó, Another biomineralising protostome with an msp130 gene and conservation of msp130 gene structure across Bilateria. 2015, Pubmed
Tanaka, EFFECTS OF THE SURFACTANTS ON THE CLEAVAGE AND FURTHER DEVELOPMENT OF THE SEA URCHIN EMBRYOS 1. THE INHIBITION OF MICROMERE FORMATION AT THE FOURTH CLEAVAGE. 1976, Pubmed , Echinobase
Telford, Phylogenomic analysis of echinoderm class relationships supports Asterozoa. 2014, Pubmed , Echinobase
Thompson, Paleogenomics of echinoids reveals an ancient origin for the double-negative specification of micromeres in sea urchins. 2017, Pubmed , Echinobase
Thuy, A New Morphological Phylogeny of the Ophiuroidea (Echinodermata) Accords with Molecular Evidence and Renders Microfossils Accessible for Cladistics. 2016, Pubmed , Echinobase
True, Developmental system drift and flexibility in evolutionary trajectories. 2001, Pubmed
Tu, Gene structure in the sea urchin Strongylocentrotus purpuratus based on transcriptome analysis. 2012, Pubmed , Echinobase
Tu, Quantitative developmental transcriptomes of the sea urchin Strongylocentrotus purpuratus. 2014, Pubmed , Echinobase
Urry, Expression of spicule matrix proteins in the sea urchin embryo during normal and experimentally altered spiculogenesis. 2000, Pubmed , Echinobase
Veis, Organic matrix-related mineralization of sea urchin spicules, spines, test and teeth. 2011, Pubmed , Echinobase
Vidavsky, Calcium transport into the cells of the sea urchin larva in relation to spicule formation. 2016, Pubmed , Echinobase
Vonica, TCF is the nuclear effector of the beta-catenin signal that patterns the sea urchin animal-vegetal axis. 2000, Pubmed , Echinobase
Voronina, Activator of G-protein signaling in asymmetric cell divisions of the sea urchin embryo. 2006, Pubmed , Echinobase
Wahl, The cis-regulatory system of the tbrain gene: Alternative use of multiple modules to promote skeletogenic expression in the sea urchin embryo. 2009, Pubmed , Echinobase
Weitzel, Differential stability of beta-catenin along the animal-vegetal axis of the sea urchin embryo mediated by dishevelled. 2004, Pubmed , Echinobase
Wessel, Primary mesenchyme cells of the sea urchin embryo require an autonomously produced, nonfibrillar collagen for spiculogenesis. 1991, Pubmed , Echinobase
Wikramanayake, Nuclear beta-catenin-dependent Wnt8 signaling in vegetal cells of the early sea urchin embryo regulates gastrulation and differentiation of endoderm and mesodermal cell lineages. 2004, Pubmed , Echinobase
Wikramanayake, beta-Catenin is essential for patterning the maternally specified animal-vegetal axis in the sea urchin embryo. 1998, Pubmed , Echinobase
Wilt, The dynamics of secretion during sea urchin embryonic skeleton formation. 2008, Pubmed , Echinobase
Wray, The origin of spicule-forming cells in a 'primitive' sea urchin (Eucidaris tribuloides) which appears to lack primary mesenchyme cells. 1988, Pubmed , Echinobase
Wu, The Snail repressor is required for PMC ingression in the sea urchin embryo. 2007, Pubmed , Echinobase
Yajima, A switch in the cellular basis of skeletogenesis in late-stage sea urchin larvae. 2007, Pubmed , Echinobase
Yajima, Small micromeres contribute to the germline in the sea urchin. 2011, Pubmed , Echinobase
Yajima, Implication of HpEts in gene regulatory networks responsible for specification of sea urchin skeletogenic primary mesenchyme cells. 2010, Pubmed , Echinobase
Yamasu, Functional organization of DNA elements regulating SM30alpha, a spicule matrix gene of sea urchin embryos. 1999, Pubmed , Echinobase
Yamazaki, Expession patterns of mesenchyme specification genes in two distantly related echinoids, Glyptocidaris crenularis and Echinocardium cordatum. 2015, Pubmed , Echinobase
Yamazaki, Larval mesenchyme cell specification in the primitive echinoid occurs independently of the double-negative gate. 2014, Pubmed , Echinobase
Yamazaki, Conserved early expression patterns of micromere specification genes in two echinoid species belonging to the orders clypeasteroida and echinoida. 2010, Pubmed , Echinobase
Yamazaki, The micro1 gene is necessary and sufficient for micromere differentiation and mid/hindgut-inducing activity in the sea urchin embryo. 2005, Pubmed , Echinobase
Yamazaki, Structure-function correlation of micro1 for micromere specification in sea urchin embryos. 2009, Pubmed , Echinobase
Yamazaki, Roles of hesC and gcm in echinoid larval mesenchyme cell development. 2016, Pubmed , Echinobase
Yamazaki, "Micromere" formation and expression of endomesoderm regulatory genes during embryogenesis of the primitive echinoid Prionocidaris baculosa. 2012, Pubmed , Echinobase
Zhu, A large-scale analysis of mRNAs expressed by primary mesenchyme cells of the sea urchin embryo. 2001, Pubmed , Echinobase
Zito, Carbonic anhydrase inhibition blocks skeletogenesis and echinochrome production in Paracentrotus lividus and Heliocidaris tuberculata embryos and larvae. 2015, Pubmed , Echinobase