Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Dev Genes Evol
2018 Jan 01;2281:1-11. doi: 10.1007/s00427-017-0599-y.
Show Gene links
Show Anatomy links
Notch-mediated lateral inhibition is an evolutionarily conserved mechanism patterning the ectoderm in echinoids.
Erkenbrack EM
.
???displayArticle.abstract???
Notch signaling is a crucial cog in early development of euechinoid sea urchins, specifying both non-skeletogenic mesodermal lineages and serotonergic neurons in the apical neuroectoderm. Here, the spatial distributions and function of delta, gcm, and hesc, three genes critical to these processes in euechinoids, are examined in the distantly related cidaroid sea urchin Eucidaris tribuloides. Spatial distribution and experimental perturbation of delta and hesc suggest that the function of Notch signaling in ectodermal patterning in early development of E. tr ibuloides is consistent with canonical lateral inhibition. Delta transcripts were observed in t he archenteron, apical ectoderm, and lateral ectoderm in gastrulating e mbryos of E. tribuloides. Perturbation of Notch signaling by either delta morpholino or treatment of DAPT downregulated hesc and upregulated delta and gcm, resulting in ectopic expression of delta and gcm. Similarly, hesc perturbation mirrored the effects of delta perturbation. Interestingly, perturbation of delta or hesc resulted in more cells expressing gcm and supernumerary pigment cells, suggesting that pigment cell proliferation is regulated by Notch in E. tribuloides. These results are consistent with an evolutionary scenario whereby, in the echinoid ancestor, Notch signaling was deployed in the ectoderm to specify neurogenic progenitors and controlled pigment cell proliferation in the dorsal ectoderm.
Artavanis-Tsakonas,
Notch signaling: cell fate control and signal integration in development.
1999, Pubmed
Artavanis-Tsakonas,
Notch signaling: cell fate control and signal integration in development.
1999,
Pubmed
Bishop,
Neural development in Eucidaris tribuloides and the evolutionary history of the echinoid larval nervous system.
2013,
Pubmed
,
Echinobase
Bray,
Notch signalling in context.
2016,
Pubmed
Burke,
Sea urchin neural development and the metazoan paradigm of neurogenesis.
2014,
Pubmed
,
Echinobase
Croce,
Dynamics of Delta/Notch signaling on endomesoderm segregation in the sea urchin embryo.
2010,
Pubmed
,
Echinobase
Davidson,
Gene regulatory networks and the evolution of animal body plans.
2006,
Pubmed
Erkenbrack,
Evolutionary rewiring of gene regulatory network linkages at divergence of the echinoid subclasses.
2015,
Pubmed
,
Echinobase
Erkenbrack,
Divergence of ectodermal and mesodermal gene regulatory network linkages in early development of sea urchins.
2016,
Pubmed
,
Echinobase
Erkenbrack,
A Conserved Role for VEGF Signaling in Specification of Homologous Mesenchymal Cell Types Positioned at Spatially Distinct Developmental Addresses in Early Development of Sea Urchins.
2017,
Pubmed
,
Echinobase
Erkenbrack,
Ancestral state reconstruction by comparative analysis of a GRN kernel operating in echinoderms.
2016,
Pubmed
,
Echinobase
Erwin,
The evolution of hierarchical gene regulatory networks.
2009,
Pubmed
Gao,
Juvenile skeletogenesis in anciently diverged sea urchin clades.
2015,
Pubmed
,
Echinobase
Garner,
Neurogenesis in sea urchin embryos and the diversity of deuterostome neurogenic mechanisms.
2016,
Pubmed
,
Echinobase
Gibson,
The origin of pigment cells in embryos of the sea urchin Strongylocentrotus purpuratus.
1985,
Pubmed
,
Echinobase
Hinman,
Evolutionary plasticity of developmental gene regulatory network architecture.
2007,
Pubmed
,
Echinobase
Kominami,
Behavior of pigment cells in gastrula-stage embryos of Hemicentrotus pulcherrimus and Scaphechinus mirabilis.
2001,
Pubmed
,
Echinobase
Kopan,
The canonical Notch signaling pathway: unfolding the activation mechanism.
2009,
Pubmed
Lapraz,
Patterning of the dorsal-ventral axis in echinoderms: insights into the evolution of the BMP-chordin signaling network.
2009,
Pubmed
,
Echinobase
Materna,
Using Morpholinos to Probe Gene Networks in Sea Urchin.
2017,
Pubmed
,
Echinobase
Materna,
Notch and Nodal control forkhead factor expression in the specification of multipotent progenitors in sea urchin.
2013,
Pubmed
,
Echinobase
Materna,
Diversification of oral and aboral mesodermal regulatory states in pregastrular sea urchin embryos.
2013,
Pubmed
,
Echinobase
Materna,
A comprehensive analysis of Delta signaling in pre-gastrular sea urchin embryos.
2012,
Pubmed
,
Echinobase
Mellott,
Notch signaling patterns neurogenic ectoderm and regulates the asymmetric division of neural progenitors in sea urchin embryos.
2017,
Pubmed
,
Echinobase
Minokawa,
Comparative studies on the skeletogenic mesenchyme of echinoids.
2017,
Pubmed
,
Echinobase
Ohguro,
Involvement of Delta and Nodal signals in the specification process of five types of secondary mesenchyme cells in embryo of the sea urchin, Hemicentrotus pulcherrimus.
2011,
Pubmed
,
Echinobase
Oliveri,
Global regulatory logic for specification of an embryonic cell lineage.
2008,
Pubmed
,
Echinobase
Peter,
A gene regulatory network controlling the embryonic specification of endoderm.
2011,
Pubmed
,
Echinobase
Popovic,
The basic helix-loop-helix region of the transcriptional repressor hairy and enhancer of split 1 is preorganized to bind DNA.
2014,
Pubmed
Range,
Specification and positioning of the anterior neuroectoderm in deuterostome embryos.
2014,
Pubmed
,
Echinobase
Ransick,
Cis-regulatory logic driving glial cells missing: self-sustaining circuitry in later embryogenesis.
2012,
Pubmed
,
Echinobase
Ransick,
cis-regulatory processing of Notch signaling input to the sea urchin glial cells missing gene during mesoderm specification.
2006,
Pubmed
,
Echinobase
Revilla-i-Domingo,
A missing link in the sea urchin embryo gene regulatory network: hesC and the double-negative specification of micromeres.
2007,
Pubmed
,
Echinobase
Röttinger,
Nemo-like kinase (NLK) acts downstream of Notch/Delta signalling to downregulate TCF during mesoderm induction in the sea urchin embryo.
2006,
Pubmed
,
Echinobase
Sherwood,
Identification and localization of a sea urchin Notch homologue: insights into vegetal plate regionalization and Notch receptor regulation.
1997,
Pubmed
,
Echinobase
Sherwood,
LvNotch signaling mediates secondary mesenchyme specification in the sea urchin embryo.
1999,
Pubmed
,
Echinobase
Smith,
Testing the molecular clock: molecular and paleontological estimates of divergence times in the Echinoidea (Echinodermata).
2006,
Pubmed
,
Echinobase
Ström,
Mediation of NGF signaling by post-translational inhibition of HES-1, a basic helix-loop-helix repressor of neuronal differentiation.
1997,
Pubmed
Sweet,
LvDelta is a mesoderm-inducing signal in the sea urchin embryo and can endow blastomeres with organizer-like properties.
2002,
Pubmed
,
Echinobase
Takata,
Behavior of pigment cells closely correlates the manner of gastrulation in sea urchin embryos.
2004,
Pubmed
,
Echinobase
Takata,
Novel population of embryonic secondary mesenchyme cells in the keyhole sand dollar Astriclypeus manni.
2011,
Pubmed
,
Echinobase
Thompson,
Paleogenomics of echinoids reveals an ancient origin for the double-negative specification of micromeres in sea urchins.
2017,
Pubmed
,
Echinobase
Thompson,
Reorganization of sea urchin gene regulatory networks at least 268 million years ago as revealed by oldest fossil cidaroid echinoid.
2015,
Pubmed
,
Echinobase
Urben,
The origin of skeleton forming cells in the sea urchin embryo.
1988,
Pubmed
,
Echinobase
Wei,
Direct development of neurons within foregut endoderm of sea urchin embryos.
2011,
Pubmed
,
Echinobase
Wray,
MOLECULAR HETEROCHRONIES AND HETEROTOPIES IN EARLY ECHINOID DEVELOPMENT.
1989,
Pubmed
Wray,
The origin of spicule-forming cells in a 'primitive' sea urchin (Eucidaris tribuloides) which appears to lack primary mesenchyme cells.
1988,
Pubmed
,
Echinobase
Yaguchi,
Fez function is required to maintain the size of the animal plate in the sea urchin embryo.
2011,
Pubmed
,
Echinobase
Yaguchi,
Zinc finger homeobox is required for the differentiation of serotonergic neurons in the sea urchin embryo.
2012,
Pubmed
,
Echinobase
Yamazaki,
Roles of hesC and gcm in echinoid larval mesenchyme cell development.
2016,
Pubmed
,
Echinobase
Yamazaki,
Larval mesenchyme cell specification in the primitive echinoid occurs independently of the double-negative gate.
2014,
Pubmed
,
Echinobase
Yamazaki,
Conserved early expression patterns of micromere specification genes in two echinoid species belonging to the orders clypeasteroida and echinoida.
2010,
Pubmed
,
Echinobase
Yamazaki,
Expession patterns of mesenchyme specification genes in two distantly related echinoids, Glyptocidaris crenularis and Echinocardium cordatum.
2015,
Pubmed
,
Echinobase
Yankura,
Gene regulatory network for neurogenesis in a sea star embryo connects broad neural specification and localized patterning.
2013,
Pubmed
,
Echinobase
