Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Protein Sci
2017 Mar 01;263:617-630. doi: 10.1002/pro.3096.
Show Gene links
Show Anatomy links
Expansion of divergent SEA domains in cell surface proteins and nucleoporin 54.
Pei J
,
Grishin NV
.
???displayArticle.abstract???
SEA (sea urchin sperm protein, enterokinase, agrin) domains, many of which possess autoproteolysis activity, have been found in a number of cell surface and secreted proteins. Despite high sequence divergence, SEA domains were also proposed to be present in dystroglycan based on a conserved autoproteolysis motif and receptor-type protein phosphatase IA-2 based on structural similarity. The presence of a SEA domain adjacent to the transmembrane segment appears to be a recurring theme in quite a number of type I transmembrane proteins on the cell surface, such as MUC1, dystroglycan, IA-2, and Notch receptors. By comparative sequence and structural analyses, we identified dystroglycan-like proteins with SEA domains in Capsaspora owczarzaki of the Filasterea group, one of the closest single-cell relatives of metazoans. We also detected novel and divergent SEA domains in a variety of cell surface proteins such as EpCAM, α/ε-sarcoglycan, PTPRR, collectrin/Tmem27, amnionless, CD34, KIAA0319, fibrocystin-like protein, and a number of cadherins. While these proteins are mostly from metazoans or their single cell relatives such as choanoflagellates and Filasterea, fibrocystin-like proteins with SEA domains were found in several other eukaryotic lineages including green algae, Alveolata, Euglenozoa, and Haptophyta, suggesting an ancient evolutionary origin. In addition, the intracellular protein Nucleoporin 54 (Nup54) acquired a divergent SEA domain in choanoflagellates and metazoans.
Abe,
Cleavage of Ig-Hepta at a "SEA" module and at a conserved G protein-coupled receptor proteolytic site.
2002, Pubmed
Abe,
Cleavage of Ig-Hepta at a "SEA" module and at a conserved G protein-coupled receptor proteolytic site.
2002,
Pubmed
Adams,
The evolution of the dystroglycan complex, a major mediator of muscle integrity.
2015,
Pubmed
Akhavan,
SEA domain proteolysis determines the functional composition of dystroglycan.
2008,
Pubmed
,
Echinobase
Akpinar,
Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation.
2005,
Pubmed
Altschul,
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.
1997,
Pubmed
Angst,
The cadherin superfamily: diversity in form and function.
2001,
Pubmed
Araç,
A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis.
2012,
Pubmed
Bafna,
Membrane-bound mucins: the mechanistic basis for alterations in the growth and survival of cancer cells.
2010,
Pubmed
Bandah-Rozenfeld,
Mutations in IMPG2, encoding interphotoreceptor matrix proteoglycan 2, cause autosomal-recessive retinitis pigmentosa.
2010,
Pubmed
Baumgartner,
The discoidin domain family revisited: new members from prokaryotes and a homology-based fold prediction.
1998,
Pubmed
Bjarnadóttir,
The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.
2004,
Pubmed
Bork,
The SEA module: a new extracellular domain associated with O-glycosylation.
1995,
Pubmed
,
Echinobase
Bork,
Domains in plexins: links to integrins and transcription factors.
1999,
Pubmed
Bozic,
The structure of the N-terminal region of murine skeletal muscle alpha-dystroglycan discloses a modular architecture.
2004,
Pubmed
Bozzi,
The Structure of the T190M Mutant of Murine α-Dystroglycan at High Resolution: Insight into the Molecular Basis of a Primary Dystroglycanopathy.
2015,
Pubmed
Bugge,
Type II transmembrane serine proteases.
2009,
Pubmed
Bycroft,
The structure of a PKD domain from polycystin-1: implications for polycystic kidney disease.
1999,
Pubmed
Camargo,
Tissue-specific amino acid transporter partners ACE2 and collectrin differentially interact with hartnup mutations.
2009,
Pubmed
Cho,
N-terminal processing is essential for release of epithin, a mouse type II membrane serine protease.
2001,
Pubmed
Chug,
Crystal structure of the metazoan Nup62•Nup58•Nup54 nucleoporin complex.
2015,
Pubmed
Cope,
Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia.
2005,
Pubmed
Cullen,
Post-translational regulation of signaling mucins.
2011,
Pubmed
Danilczyk,
Essential role for collectrin in renal amino acid transport.
2006,
Pubmed
Dickens,
Cadherin-like domains in alpha-dystroglycan, alpha/epsilon-sarcoglycan and yeast and bacterial proteins.
2002,
Pubmed
Dilaver,
Proteolytic processing of the receptor-type protein tyrosine phosphatase PTPBR7.
2007,
Pubmed
Fairweather,
Molecular basis for the interaction of the mammalian amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin.
2015,
Pubmed
Finn,
HMMER web server: 2015 update.
2015,
Pubmed
Finn,
The Pfam protein families database: towards a more sustainable future.
2016,
Pubmed
Fredriksson,
Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions.
2002,
Pubmed
Furness,
Beyond mere markers: functions for CD34 family of sialomucins in hematopoiesis.
2006,
Pubmed
Fyfe,
The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless.
2004,
Pubmed
Gao,
Sequential and distinct roles of the cadherin domain-containing protein Axl2p in cell polarization in yeast cell cycle.
2007,
Pubmed
Gordon,
Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL.
2009,
Pubmed
Gordon,
Structural basis for autoinhibition of Notch.
2007,
Pubmed
Guo,
MANSC: a seven-cysteine-containing domain present in animal membrane and extracellular proteins.
2004,
Pubmed
Harris,
Polycystic kidney disease.
2009,
Pubmed
He,
G8: a novel domain associated with polycystic kidney disease and non-syndromic hearing loss.
2006,
Pubmed
Hendriks,
PTPRR protein tyrosine phosphatase isoforms and locomotion of vesicles and mice.
2009,
Pubmed
Henry,
Dystroglycan: an extracellular matrix receptor linked to the cytoskeleton.
1996,
Pubmed
Holm,
Dali server: conservation mapping in 3D.
2010,
Pubmed
Hu,
Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins.
1996,
Pubmed
Hulpiau,
Molecular evolution of the cadherin superfamily.
2009,
Pubmed
Hunt,
von Willebrand factor shares a distinctive cysteine-rich domain with thrombospondin and procollagen.
1987,
Pubmed
Iozzo,
Matrix proteoglycans: from molecular design to cellular function.
1998,
Pubmed
Jenkins,
The architecture of parallel beta-helices and related folds.
2001,
Pubmed
Jonckheere,
Membrane-bound mucin modular domains: from structure to function.
2013,
Pubmed
Kaimori,
Polyductin undergoes notch-like processing and regulated release from primary cilia.
2007,
Pubmed
Kazmierczak,
Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells.
2007,
Pubmed
Kobori,
The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease.
2007,
Pubmed
Kozyraki,
Multiligand endocytosis and congenital defects: roles of cubilin, megalin and amnionless.
2007,
Pubmed
Kufe,
Mucins in cancer: function, prognosis and therapy.
2009,
Pubmed
Käll,
A combined transmembrane topology and signal peptide prediction method.
2004,
Pubmed
Lan,
Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma.
1994,
Pubmed
Lang,
The closest unicellular relatives of animals.
2002,
Pubmed
Langenhan,
Sticky signaling--adhesion class G protein-coupled receptors take the stage.
2013,
Pubmed
Letunic,
SMART: recent updates, new developments and status in 2015.
2015,
Pubmed
Levitin,
The MUC1 SEA module is a self-cleaving domain.
2005,
Pubmed
,
Echinobase
Liao,
An ancient autoproteolytic domain found in GAIN, ZU5 and Nucleoporin98.
2014,
Pubmed
Light,
Enterokinase (enteropeptidase): comparative aspects.
1989,
Pubmed
Lim,
The sarcoglycan complex in limb-girdle muscular dystrophy.
1998,
Pubmed
Logeat,
The Notch1 receptor is cleaved constitutively by a furin-like convertase.
1998,
Pubmed
Lum,
Orphan receptor GPR110, an oncogene overexpressed in lung and prostate cancer.
2010,
Pubmed
Macao,
Autoproteolysis coupled to protein folding in the SEA domain of the membrane-bound MUC1 mucin.
2006,
Pubmed
Maeda,
Solution structure of the SEA domain from the murine homologue of ovarian cancer antigen CA125 (MUC16).
2004,
Pubmed
Manes,
Mutations in IMPG1 cause vitelliform macular dystrophies.
2013,
Pubmed
Matsushima,
Structural characterization of porcine enteropeptidase.
1994,
Pubmed
Moore,
Dystroglycan versatility in cell adhesion: a tale of multiple motifs.
2010,
Pubmed
Nichols,
Origin of metazoan cadherin diversity and the antiquity of the classical cadherin/β-catenin complex.
2012,
Pubmed
Nielsen,
Novel functions of the CD34 family.
2008,
Pubmed
Noguera,
X-ray structure of the mature ectodomain of phogrin.
2015,
Pubmed
Oda,
Evolution: structural and functional diversity of cadherin at the adherens junction.
2011,
Pubmed
Oda,
Nonchordate classic cadherins have a structurally and functionally unique domain that is absent from chordate classic cadherins.
1999,
Pubmed
Palmai-Pallag,
The role of the SEA (sea urchin sperm protein, enterokinase and agrin) module in cleavage of membrane-tethered mucins.
2005,
Pubmed
,
Echinobase
Paracchini,
Association of the KIAA0319 dyslexia susceptibility gene with reading skills in the general population.
2008,
Pubmed
Pavšič,
Crystal structure and its bearing towards an understanding of key biological functions of EpCAM.
2014,
Pubmed
Pei,
PROMALS3D: multiple protein sequence alignment enhanced with evolutionary and three-dimensional structural information.
2014,
Pubmed
Primo,
Structure of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase IA-2.
2008,
Pubmed
,
Echinobase
Ramsay,
Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis.
2009,
Pubmed
Schnell,
EpCAM proteolysis: new fragments with distinct functions?
2013,
Pubmed
Schnell,
EpCAM: structure and function in health and disease.
2013,
Pubmed
Shibuya,
Initial characterization of an uromodulin-like 1 gene on human chromosome 21q22.3.
2004,
Pubmed
,
Echinobase
Shvartsur,
Trop2 and its overexpression in cancers: regulation and clinical/therapeutic implications.
2015,
Pubmed
Suga,
The Capsaspora genome reveals a complex unicellular prehistory of animals.
2013,
Pubmed
Söding,
The HHpred interactive server for protein homology detection and structure prediction.
2005,
Pubmed
Tanoue,
New insights into Fat cadherins.
2005,
Pubmed
Tarakci,
The sarcoglycan complex in skeletal muscle.
2016,
Pubmed
Uhland,
Matriptase and its putative role in cancer.
2006,
Pubmed
Usui,
Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled.
1999,
Pubmed
Velayos-Baeza,
The dyslexia-associated KIAA0319 protein undergoes proteolytic processing with {gamma}-secretase-independent intramembrane cleavage.
2010,
Pubmed
Waite,
Myoclonus dystonia and muscular dystrophy: ɛ-sarcoglycan is part of the dystrophin-associated protein complex in brain.
2016,
Pubmed
Wreschner,
Generation of ligand-receptor alliances by "SEA" module-mediated cleavage of membrane-associated mucin proteins.
2002,
Pubmed
Xu,
Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region.
2015,
Pubmed
Zhang,
The role for HNF-1beta-targeted collectrin in maintenance of primary cilia and cell polarity in collecting duct cells.
2007,
Pubmed
Zhang,
Collectrin, a collecting duct-specific transmembrane glycoprotein, is a novel homolog of ACE2 and is developmentally regulated in embryonic kidneys.
2001,
Pubmed
van Tetering,
Proteolytic cleavage of Notch: "HIT and RUN".
2011,
Pubmed