Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
PeerJ
2016 Jan 01;4:e1876. doi: 10.7717/peerj.1876.
Show Gene links
Show Anatomy links
What doesn''t kill them makes them stronger: an association between elongation factor 1-α overdominance in the sea star Pisaster ochraceus and "sea star wasting disease".
Wares JP
,
Schiebelhut LM
.
???displayArticle.abstract???
In recent years, a massive mortality event has killed millions of sea stars, of many different species, along the Pacific coast of North America. This disease event, known as ''sea star wasting disease'' (SSWD), is linked to viral infection. In one affected sea star (Pisaster ochraceus), previous work had identified that the elongation factor 1-α locus (EF1A) harbored an intronic insertion allele that is lethal when homozygous yet appears to be maintained at moderate frequency in populations through increased fitness for heterozygotes. The environmental conditions supporting this increased fitness are unknown, but overdominance is often associated with disease. Here, we evaluate populations of P. ochraceus to identify the relationship between SSWD and EF1A genotype. Our data suggest that there may be significantly decreased occurrence of SSWD in individuals that are heterozygous at this locus. These results suggest further studies are warranted to understand the functional relationship between diversity at EF1A and survival in P. ochraceus.
Figure 1. Results from analysis of 8 individuals on 2% agarose gel following PCR amplification as noted in ‘Methods.’Fragments only vary by 6bp in length so gel must be run for ∼60 min under typical conditions (∼90–100 V). Heterozygotes are denoted ‘AB’ and homozygotes denoted ‘AA’ on gel image. Size standards are on left side of gel.
ALLISON,
The distribution of the sickle-cell trait in East Africa and elsewhere, and its apparent relationship to the incidence of subtertian malaria.
1954, Pubmed
ALLISON,
The distribution of the sickle-cell trait in East Africa and elsewhere, and its apparent relationship to the incidence of subtertian malaria.
1954,
Pubmed
Aidoo,
Protective effects of the sickle cell gene against malaria morbidity and mortality.
2002,
Pubmed
Bates,
Effects of temperature, season and locality on wasting disease in the keystone predatory sea star Pisaster ochraceus.
2009,
Pubmed
,
Echinobase
Buckley,
The cellular response to heat stress in the goby Gillichthys mirabilis: a cDNA microarray and protein-level analysis.
2006,
Pubmed
Bukovnik,
Heat tolerance and expression of protein synthesis elongation factors, EF-Tu and EF-1α, in spring wheat.
2009,
Pubmed
Cholera,
Impaired cytoadherence of Plasmodium falciparum-infected erythrocytes containing sickle hemoglobin.
2008,
Pubmed
Eisenlord,
Ochre star mortality during the 2014 wasting disease epizootic: role of population size structure and temperature.
2016,
Pubmed
,
Echinobase
Fangue,
Intraspecific variation in thermal tolerance and heat shock protein gene expression in common killifish, Fundulus heteroclitus.
2006,
Pubmed
Fuess,
Up in Arms: Immune and Nervous System Response to Sea Star Wasting Disease.
2015,
Pubmed
,
Echinobase
Gemmell,
Heterozygote advantage for fecundity.
2006,
Pubmed
Harley,
Color polymorphism and genetic structure in the sea star Pisaster ochraceus.
2006,
Pubmed
,
Echinobase
Harvell,
Climate warming and disease risks for terrestrial and marine biota.
2002,
Pubmed
Hewson,
Densovirus associated with sea-star wasting disease and mass mortality.
2014,
Pubmed
,
Echinobase
Jurgens,
Patterns of Mass Mortality among Rocky Shore Invertebrates across 100 km of Northeastern Pacific Coastline.
2015,
Pubmed
,
Echinobase
Pankey,
Overdominant maintenance of diversity in the sea star Pisaster ochraceus.
2009,
Pubmed
,
Echinobase
Pompanon,
Genotyping errors: causes, consequences and solutions.
2005,
Pubmed
Stearns,
The effects of enhanced expression of elongation factor EF-1 alpha on lifespan in Drosophila melanogaster. IV. A summary of three experiments.
1993,
Pubmed
Stearns,
Effects on fitness components of enhanced expression of elongation factor EF-1alpha in Drosophila melanogaster. I. The contrasting approaches of molecular and population biologists.
1993,
Pubmed
Whiteley,
Genetic rescue to the rescue.
2015,
Pubmed
