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Echinobase
ECB-ART-43532
Mar Drugs 2014 Jul 24;128:4274-90. doi: 10.3390/md12084274.
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Cytotoxic and apoptosis-inducing activity of triterpene glycosides from Holothuria scabra and Cucumaria frondosa against HepG2 cells.

Wang J , Han H , Chen X , Yi Y , Sun H .


Abstract
The cytotoxic effects of thirteen triterpene glycosides from Holothuria scabra Jaeger and Cucumaria frondosa Gunnerus (Holothuroidea) against four human cell lines were detected and their cytotoxicity-structure relationships were established. The apoptosis-inducing activity of a more potent glycoside echinoside A (1) in HepG2 cells was further investigated by determining its effect on the morphology, mitochondrial transmembrane potential (Δψm) and mRNA expression levels of the apoptosis-related genes. The results showed that the number of glycosyl residues in sugar chains and the side chain of aglycone could affect their cytotoxicity towards tumor cells and selective cytotoxicity. 1 significantly inhibited cell viability and induced apoptosis in HepG2 cells. 1 also markedly decreased the Δψm and Bcl-2/Bax mRNA express ratio, and up-regulated the mRNA expression levels of Caspase-3, Caspase-8 and Caspase-9 in HepG2 cells. Therefore, 1 induced apoptosis in HepG2 cells through both intrinsic and extrinsic pathway. These findings could potentially promote the usage of these glycosides as leading compounds for developing new antitumor drugs.

PubMed ID: 25062508
PMC ID: PMC4145316
Article link: Mar Drugs


Species referenced: Echinodermata
Genes referenced: bax LOC100893907 LOC115919910 LOC590297


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References [+] :
Aminin, Antitumor activity of the immunomodulatory lead Cumaside. 2010, Pubmed, Echinobase