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Effects of dietary sea cucumber saponin on the gene expression rhythm involved in circadian clock and lipid metabolism in mice during nighttime-feeding.
Wen M
,
Cui J
,
Xu J
,
Xue Y
,
Wang J
,
Xue C
,
Wang Y
.
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In mammals, clock rhythms exist not only in the suprachiasmatic nucleus, which is entrained by light/dark (LD) cycles, but also in most peripheral tissues. Recent studies have revealed that most physiology and behavior are subject to well-controlled daily oscillations; similarly, metabolic state influences the diurnal rhythm too. Previous studies have indicated that dietary sea cucumber saponin (SCS) could improve glucose and lipid metabolism of rodent. However, whether SCS could affect the expression of clock genes, which is involved in lipid metabolism, is unknown at present. The aim of this study is to investigate the effects of SCS on the clock and clock-controlled genes involved in lipid metabolism. ICR male mice were divided into a control and SCS group mice (add 0.03% sea cucumber saponin to regular chow) and were fed at night (2030-0830 hours). After 2 weeks, clock genes expression in brain and liver, blood glucose, hormones, and lipid metabolic markers were analyzed. The results showed that dietary SCS caused alteration in rhythms and/or amplitudes of clock genes was more significant in brain than in liver. In addition, peroxisome proliferator-activated receptor (PPARα), sterol regulatory element binding protein-1c (SREBP-1c), together with their target genes carnitine palmitoyl transferase (CPT), and fatty acid synthase (FAS) showed marked changes in rhythm and/or amplitude in SCS group mice. These results suggested that SCS could affect the daily expression patterns of clock genes in brain and liver tissues, and alter the clock-controlled genes involved in lipid metabolism.
Ando,
Rhythmic messenger ribonucleic acid expression of clock genes and adipocytokines in mouse visceral adipose tissue.
2005, Pubmed
Ando,
Rhythmic messenger ribonucleic acid expression of clock genes and adipocytokines in mouse visceral adipose tissue.
2005,
Pubmed
Ando,
Profile of rhythmic gene expression in the livers of obese diabetic KK-A(y) mice.
2006,
Pubmed
Antle,
Adenosine and caffeine modulate circadian rhythms in the Syrian hamster.
2001,
Pubmed
Bass,
Circadian integration of metabolism and energetics.
2010,
Pubmed
Báez-Ruiz,
Metabolic adaptations of liver mitochondria during restricted feeding schedules.
2005,
Pubmed
Cailotto,
The suprachiasmatic nucleus controls the daily variation of plasma glucose via the autonomic output to the liver: are the clock genes involved?
2005,
Pubmed
Chen,
Circadian rhythm of TSH levels in subjects with Alzheimer's disease (AD).
2013,
Pubmed
Chen,
Chronic ethanol consumption impairs the circadian rhythm of pro-opiomelanocortin and period genes mRNA expression in the hypothalamus of the male rat.
2004,
Pubmed
Chimin,
Chronic glucocorticoid treatment enhances lipogenic activity in visceral adipocytes of male Wistar rats.
2014,
Pubmed
Cordeiro,
Non-classic thyroid hormone signalling involved in hepatic lipid metabolism.
2013,
Pubmed
De Boer,
Daily variations in plasma noradrenaline, adrenaline and corticosterone concentrations in rats.
1987,
Pubmed
Duntas,
The effect of thyroid disorders on lipid levels and metabolism.
2012,
Pubmed
Froy,
Metabolism and circadian rhythms--implications for obesity.
2010,
Pubmed
Froy,
The relationship between nutrition and circadian rhythms in mammals.
2007,
Pubmed
Hammes,
Fatty acid synthase: elementary steps in catalysis and regulation.
1985,
Pubmed
Hiai,
Stimulation of pituitary-adrenocortical system by ginseng saponin.
1979,
Pubmed
Horton,
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.
2002,
Pubmed
Hu,
Dietary saponins of sea cucumber ameliorate obesity, hepatic steatosis, and glucose intolerance in high-fat diet-fed mice.
2012,
Pubmed
,
Echinobase
Hu,
Effects of bioactive components of sea cucumber on the serum, liver lipid profile and lipid absorption.
2012,
Pubmed
,
Echinobase
Inoue,
CLOCK/BMAL1 is involved in lipid metabolism via transactivation of the peroxisome proliferator-activated receptor (PPAR) response element.
2005,
Pubmed
Iwanaga,
Per2 gene expressions in the suprachiasmatic nucleus and liver differentially respond to nutrition factors in rats.
2005,
Pubmed
Kalsbeek,
Circadian rhythms in the hypothalamo-pituitary-adrenal (HPA) axis.
2012,
Pubmed
Kohsaka,
High-fat diet disrupts behavioral and molecular circadian rhythms in mice.
2007,
Pubmed
Kornmann,
System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock.
2007,
Pubmed
Langlais,
Thiamine deficiency-induced disruptions in the diurnal rhythm and regulation of body temperature in the rat.
1998,
Pubmed
Liu,
Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism.
2007,
Pubmed
Lizier,
The nutrigenomic investigation of C57BL/6N mice fed a short-term high-fat diet highlights early changes in clock genes expression.
2013,
Pubmed
McNamara,
Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock.
2001,
Pubmed
Mendoza,
Feeding cues alter clock gene oscillations and photic responses in the suprachiasmatic nuclei of mice exposed to a light/dark cycle.
2005,
Pubmed
Mohri,
Alterations of circadian expressions of clock genes in Dahl salt-sensitive rats fed a high-salt diet.
2003,
Pubmed
Osborne,
Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action.
2000,
Pubmed
Rosenwasser,
Circadian activity rhythms in selectively bred ethanol-preferring and nonpreferring rats.
2005,
Pubmed
Ruiter,
The daily rhythm in plasma glucagon concentrations in the rat is modulated by the biological clock and by feeding behavior.
2003,
Pubmed
Sherman,
Caffeine alters circadian rhythms and expression of disease and metabolic markers.
2011,
Pubmed
Shimba,
Brain and muscle Arnt-like protein-1 (BMAL1), a component of the molecular clock, regulates adipogenesis.
2005,
Pubmed
Shirai,
Bidirectional CLOCK/BMAL1-dependent circadian gene regulation by retinoic acid in vitro.
2006,
Pubmed
Takahashi,
Chronic mild stress alters circadian expressions of molecular clock genes in the liver.
2013,
Pubmed
Vollmers,
Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression.
2009,
Pubmed
Wang,
The orphan nuclear receptor Rev-erb alpha regulates circadian expression of plasminogen activator inhibitor type 1.
2006,
Pubmed
Wang,
Timed high-fat diet in the evening affects the hepatic circadian clock and PPARα-mediated lipogenic gene expressions in mice.
2013,
Pubmed
Young,
Alterations of the circadian clock in the heart by streptozotocin-induced diabetes.
2002,
Pubmed
