ECB-ART-43041
Dev Dyn
2014 Apr 01;2434:568-87. doi: 10.1002/dvdy.24038.
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Selective accumulation of germ-line associated gene products in early development of the sea star and distinct differences from germ-line development in the sea urchin.
Fresques T
,
Zazueta-Novoa V
,
Reich A
,
Wessel GM
.
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BACKGROUND: Echinodermata is a diverse phylum, a sister group to chordates, and contains diverse organisms that may be useful to understand varied mechanisms of germ-line specification. RESULTS: We tested 23 genes in development of the sea star Patiria miniata that fall into five categories: (1) Conserved germ-line factors; (2) Genes involved in the inductive mechanism of germ-line specification; (3) Germ-line associated genes; (4) Molecules involved in left-right asymmetry; and (5) Genes involved in regulation and maintenance of the genome during early embryogenesis. Overall, our results support the contention that the posterior enterocoel is a source of the germ line in the sea star P. miniata. CONCLUSIONS: The germ line in this organism appears to be specified late in embryogenesis, and in a pattern more consistent with inductive interactions amongst cells. This is distinct from the mechanism seen in sea urchins, a close relative of the sea star clad. We propose that P. miniata may serve as a valuable model to study inductive mechanisms of germ-cell specification and when compared with germ-line formation in the sea urchin S. purpuratus may reveal developmental transitions that occur in the evolution of inherited and inductive mechanisms of germ-line specification.
???displayArticle.pubmedLink??? 24038550
???displayArticle.pmcLink??? PMC3996927
???displayArticle.link??? Dev Dyn
???displayArticle.grants??? [+]
R01 HD028152 NICHD NIH HHS , S10 RR027634 NCRR NIH HHS , T32 GM007601 NIGMS NIH HHS , 2R01HD028152 NICHD NIH HHS
Genes referenced: LOC100887844 LOC115919910
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