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Echinobase
ECB-ART-42696
PLoS Genet January 1, 2012; 8 (12): e1003121.
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Reciprocal signaling between the ectoderm and a mesendodermal left-right organizer directs left-right determination in the sea urchin embryo.

Bessodes N , Haillot E , Duboc V , Röttinger E , Lahaye F , Lepage T .


Abstract
During echinoderm development, expression of nodal on the right side plays a crucial role in positioning of the rudiment on the left side, but the mechanisms that restrict nodal expression to the right side are not known. Here we show that establishment of left-right asymmetry in the sea urchin embryo relies on reciprocal signaling between the ectoderm and a left-right organizer located in the endomesoderm. FGF/ERK and BMP2/4 signaling are required to initiate nodal expression in this organizer, while Delta/Notch signaling is required to suppress formation of this organizer on the left side of the archenteron. Furthermore, we report that the H(+)/K(+)-ATPase is critically required in the Notch signaling pathway upstream of the S3 cleavage of Notch. Our results identify several novel players and key early steps responsible for initiation, restriction, and propagation of left-right asymmetry during embryogenesis of a non-chordate deuterostome and uncover a functional link between the H(+)/K(+)-ATPase and the Notch signaling pathway.

PubMed ID: 23271979
PMC ID: PMC3521660
Article link: PLoS Genet


Species referenced: Echinodermata
Genes referenced: adcy10 bmp2 bmpr1b fgf fgfr3 foxa1 foxf1 gcml lefty1 LOC100887844 LOC115919910 LOC115921237 LOC115924597 LOC115925415 LOC576066 LOC581395 LOC587333 LOC593908 msp130 nodall pitx2 pole univin
Morpholinos: dll1 MO4


Article Images: [+] show captions
References [+] :
Aihara, Inversion of left-right asymmetry in the formation of the adult rudiment in sea urchin larvae: removal of a part of embryos at the gastrula stage. 2001, Pubmed, Echinobase