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ECB-ART-42494
Mol Reprod Dev 2012 Oct 01;7910:680-8. doi: 10.1002/mrd.22073.
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The forkhead transcription factor FoxY regulates Nanos.



Abstract
FoxY is a member of the forkhead transcription factor family that appeared enriched in the presumptive germ line of sea urchins (Ransick et al. Dev Biol 2002;246:132). Here, we test the hypothesis that FoxY is involved in germ line determination in this animal. We found two splice forms of FoxY that share the same DNA-binding domain, but vary in the carboxy-terminal trans-activation/repression domain. Both forms of the FoxY protein are present in the egg and in the early embryo, and their mRNAs accumulate to their highest levels in the small micromeres and adjacent non-skeletogenic mesoderm. Knockdown of FoxY resulted in a dramatic decrease in Nanos mRNA and protein levels as well as a loss of coelomic pouches in 2-week-old larvae. Our results indicate that FoxY positively regulates Nanos at the transcriptional level and is essential for reproductive potential in this organism.

PubMed ID: 22777754
PMC ID: PMC3473121
Article link: Mol Reprod Dev
Grant support: [+]

Genes referenced: foxy LOC100887844
Morpholinos: foxy MO1

References [+] :
Ali, Cis-regulatory elements affecting the Nanos gene promoter in the germline stem cells. 2010, Pubmed