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Biophys J
2012 Jun 06;10211:2481-8. doi: 10.1016/j.bpj.2012.03.075.
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What is the core oscillator in the speract-activated pathway of the Strongylocentrotus purpuratus sperm flagellum?
Aguilera LU
,
Galindo BE
,
Sánchez D
,
Santillán M
.
???displayArticle.abstract??? Sperm chemotaxis has an important role in fertilization. Most of our knowledge regarding this phenomenon comes from studies in organisms whose fertilization occurs externally, like sea urchins. Sea urchin spermatozoa respond to sperm-activating peptides, which diffuse from the egg jelly coat and interact with their receptor in the flagellum, triggering several physiological responses: changes in membrane potential, intracellular pH, cyclic nucleotide levels, and intracellular Ca2+ concentration ([Ca2+]). In particular, flagellar [Ca2+] has been shown to oscillate. These [Ca2+] oscillations are correlated with changes in the flagellar shape and so with the regulation of the sperm swimming paths. In this study, we demonstrate, from a mathematical modeling perspective, that the reported speract-activated signaling pathway in Strongylocentrotus purpuratus (speract being a sperm-activating peptide specific to this species) has the necessary elements to replicate the reported [Ca2+] oscillations. We further investigate which elements of this signaling pathway constitute the core oscillator.
Aguilera,
What is the core oscillator in the speract-activated pathway of the Strongylocentrotus purpuratus sperm flagellum?
2012, Pubmed
Aguilera,
What is the core oscillator in the speract-activated pathway of the Strongylocentrotus purpuratus sperm flagellum?
2012,
Pubmed
Brokaw,
Calcium-induced asymmetrical beating of triton-demembranated sea urchin sperm flagella.
1979,
Pubmed
,
Echinobase
Böhmer,
Ca2+ spikes in the flagellum control chemotactic behavior of sperm.
2005,
Pubmed
,
Echinobase
Cheng,
Niflumic acid alters gating of HCN2 pacemaker channels by interaction with the outer region of S4 voltage sensing domains.
2009,
Pubmed
Cukkemane,
Cooperative and uncooperative cyclic-nucleotide-gated ion channels.
2011,
Pubmed
Dangott,
Cloning of the mRNA for the protein that crosslinks to the egg peptide speract.
1989,
Pubmed
,
Echinobase
Darszon,
Sperm-activating peptides in the regulation of ion fluxes, signal transduction and motility.
2008,
Pubmed
,
Echinobase
Espinal,
Discrete dynamics model for the speract-activated Ca2+ signaling network relevant to sperm motility.
2011,
Pubmed
,
Echinobase
Galindo,
Sp-tetraKCNG: A novel cyclic nucleotide gated K(+) channel.
2007,
Pubmed
,
Echinobase
Gauss,
Molecular identification of a hyperpolarization-activated channel in sea urchin sperm.
1998,
Pubmed
,
Echinobase
Granados-Gonzalez,
Identification of voltage-dependent Ca2+ channels in sea urchin sperm.
2005,
Pubmed
,
Echinobase
Gu,
Computational model of the insect pheromone transduction cascade.
2009,
Pubmed
Guerrero,
Tuning sperm chemotaxis by calcium burst timing.
2010,
Pubmed
,
Echinobase
Kaupp,
Mechanisms of sperm chemotaxis.
2008,
Pubmed
,
Echinobase
Kaupp,
Olfactory signalling in vertebrates and insects: differences and commonalities.
2010,
Pubmed
Nomura,
A soluble adenylyl cyclase from sea urchin spermatozoa.
2005,
Pubmed
,
Echinobase
Novák,
Design principles of biochemical oscillators.
2008,
Pubmed
Publicover,
[Ca2+]i signalling in sperm--making the most of what you've got.
2007,
Pubmed
Riffell,
Sex and flow: the consequences of fluid shear for sperm-egg interactions.
2007,
Pubmed
Shin,
Inactivation in HCN channels results from reclosure of the activation gate: desensitization to voltage.
2004,
Pubmed
Sochivko,
The Ca(V)2.3 Ca(2+) channel subunit contributes to R-type Ca(2+) currents in murine hippocampal and neocortical neurones.
2002,
Pubmed
Stephan,
ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification.
2009,
Pubmed
Strünker,
A K+-selective cGMP-gated ion channel controls chemosensation of sperm.
2006,
Pubmed
,
Echinobase
Su,
A flagellar K(+)-dependent Na(+)/Ca(2+) exchanger keeps Ca(2+) low in sea urchin spermatozoa.
2002,
Pubmed
,
Echinobase
Su,
Cyclic GMP-specific phosphodiesterase-5 regulates motility of sea urchin spermatozoa.
2006,
Pubmed
,
Echinobase
Sánchez,
Sea urchin sperm cation-selective channels directly modulated by cAMP.
2001,
Pubmed
,
Echinobase
Thorpe,
The membrane form of guanylate cyclase. Homology with a subunit of the cytoplasmic form of the enzyme.
1989,
Pubmed
,
Echinobase
Ward,
Chemotaxis of Arbacia punctulata spermatozoa to resact, a peptide from the egg jelly layer.
1985,
Pubmed
,
Echinobase
Ward,
Phosphorylation of membrane-bound guanylate cyclase of sea urchin spermatozoa.
1986,
Pubmed
,
Echinobase
Ward,
Dephosphorylation of sea urchin sperm guanylate cyclase during fertilization.
1986,
Pubmed
,
Echinobase
Wood,
Speract induces calcium oscillations in the sperm tail.
2003,
Pubmed
,
Echinobase
Wood,
Real-time analysis of the role of Ca(2+) in flagellar movement and motility in single sea urchin sperm.
2005,
Pubmed
,
Echinobase
Wood,
Altering the speract-induced ion permeability changes that generate flagellar Ca2+ spikes regulates their kinetics and sea urchin sperm motility.
2007,
Pubmed
,
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