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ECB-ART-40466
J Asian Nat Prod Res 2007 Jan 01;96-8:609-15. doi: 10.1080/10286020600882676.
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Hillasides A and B, two new cytotoxic triterpene glycosides from the sea cucumber Holothuria hilla Lesson.

Wu J , Yi YH , Tang HF , Wu HM , Zhou ZR .


Abstract
Two new triterpene glycosides, hillasides A (1) and B (2), were isolated from the sea cucumber H. hilla Lesson, together with one known glycoside holothuria B (3). Their structures were deduced by extensive spectral analysis and chemical evidences. The presence of conjugated double bonds [22E,24-diene] in the aglycone of 1 is a rare structural feature among sea cucumber glycosides. The two glycosides showed significant cytotoxicity against eight human tumour cell lines (A-549, MCF-7, IA9, CAKI-1, PC-3, KB, KB-VIN and HCT-8) with IC(50) in the range of 0.1-3.8 microg/ml.

PubMed ID: 17943555
Article link: J Asian Nat Prod Res
Grant support: [+]

Genes referenced: LOC100887844 LOC100893907 LOC115919910 LOC593824