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Chem Biodivers 2007 Mar 01;43:450-7. doi: 10.1002/cbdv.200790037.
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A new cytotoxic lanostane-type triterpene glycoside from the sea cucumber Holothuria impatiens.

Sun P , Liu BS , Yi YH , Li L , Gui M , Tang HF , Zhang DZ , Zhang SL .

A new lanostane-type triterpene glycoside, impatienside A (1), was isolated from the sea cucumber Holothuria impatiens, together with a structurally related, known compound, bivittoside D (2). Their structures were elucidated by in-depth spectroscopic and mass-spectrometric methods, including (1)H-, (13)C-, and 2D-NMR, ESI-MS, and HR-ESI-MS experiments, as well as by chemical evidence. Compounds 1 and 2 possess the same hexasaccharide moieties, but differ slightly in their holostane-type triterpene aglycone. The two glycosides were found to exhibit in vitro cytotoxicities similar to or better than those of the potent anticancer drug etoposide (V-16) against seven different human tumor cells, with IC50 values of 0.37-2.75 microg/ml.

PubMed ID: 17372947
Article link: Chem Biodivers

Genes referenced: LOC100887844