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Dev Biol
2006 Dec 01;3001:121-31. doi: 10.1016/j.ydbio.2006.08.045.
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A genome-wide survey of the evolutionarily conserved Wnt pathways in the sea urchin Strongylocentrotus purpuratus.
Croce JC
,
Wu SY
,
Byrum C
,
Xu R
,
Duloquin L
,
Wikramanayake AH
,
Gache C
,
McClay DR
.
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The Wnt pathways are evolutionarily well-conserved signal transduction pathways that are known to play important roles in all Metazoans investigated to date. Here, we examine the Wnt pathway genes and target genes present in the genome of the echinoderm Strongylocentrotus purpuratus. Analysis of the Wnt genes revealed that eleven of the thirteen reported Wnt subfamilies are represented in sea urchin, with the intriguing identification of a Wnt-A ortholog thought to be absent in deuterostomes. A phylogenetic study of the Frizzled proteins, the Wnt receptors, performed throughout the animal kingdom showed that not all Frizzled subfamilies were present in the metazoan common ancestor, e.g. Fz3/6 emerged later during evolution. Using sequence analysis, orthologs of the vast majority of the cellular machinery involved in transducing the three types of Wnt pathways were found in the sea urchin genome. Furthermore, of about one hundred target genes identified in other organisms, more than half have clear echinoderm orthologs. Thus, these analyses produce new inputs in the evolutionary history of the Wnt genes in an animal occupying a position that offers great insights into the basal properties of deuterostomes.
Altschul,
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.
1997, Pubmed
Altschul,
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.
1997,
Pubmed
Augustin,
Dickkopf related genes are components of the positional value gradient in Hydra.
2006,
Pubmed
Bateman,
The Pfam protein families database.
2004,
Pubmed
Benson,
GenBank.
2005,
Pubmed
Bhanot,
A new member of the frizzled family from Drosophila functions as a Wingless receptor.
1996,
Pubmed
Cadigan,
Wnt signaling: a common theme in animal development.
1997,
Pubmed
Cathala,
A method for isolation of intact, translationally active ribonucleic acid.
1983,
Pubmed
Croce,
Frizzled5/8 is required in secondary mesenchyme cells to initiate archenteron invagination during sea urchin development.
2006,
Pubmed
,
Echinobase
Croce,
The canonical Wnt pathway in embryonic axis polarity.
2006,
Pubmed
,
Echinobase
DasGupta,
Functional genomic analysis of the Wnt-wingless signaling pathway.
2005,
Pubmed
Fedders,
A Dickkopf- 3-related gene is expressed in differentiating nematocytes in the basal metazoan Hydra.
2004,
Pubmed
Ferkowicz,
Phylogenetic relationships and developmental expression of three sea urchin Wnt genes.
1998,
Pubmed
,
Echinobase
Glinka,
Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction.
1998,
Pubmed
Guder,
An ancient Wnt-Dickkopf antagonism in Hydra.
2006,
Pubmed
Heisenberg,
Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation.
2000,
Pubmed
Hino,
A genomewide survey of developmentally relevant genes in Ciona intestinalis. VI. Genes for Wnt, TGFbeta, Hedgehog and JAK/STAT signaling pathways.
2003,
Pubmed
Hobmayer,
WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra.
2000,
Pubmed
Holland,
Heads or tails? Amphioxus and the evolution of anterior-posterior patterning in deuterostomes.
2002,
Pubmed
,
Echinobase
Hotta,
A genome-wide survey of the genes for planar polarity signaling or convergent extension-related genes in Ciona intestinalis and phylogenetic comparisons of evolutionary conserved signaling components.
2003,
Pubmed
Huang,
The Frizzled family: receptors for multiple signal transduction pathways.
2004,
Pubmed
Hubbard,
Ensembl 2005.
2005,
Pubmed
Huelsenbeck,
Bayesian inference of phylogeny and its impact on evolutionary biology.
2001,
Pubmed
Hwang,
Wnt-3a regulates chondrocyte differentiation via c-Jun/AP-1 pathway.
2005,
Pubmed
Illies,
Cloning and developmental expression of a novel, secreted frizzled-related protein from the sea urchin, Strongylocentrotus purpuratus.
2002,
Pubmed
,
Echinobase
Imai,
(beta)-catenin mediates the specification of endoderm cells in ascidian embryos.
2000,
Pubmed
Jockusch,
Phylogenetic analysis of the Wnt gene family and discovery of an arthropod wnt-10 orthologue.
2000,
Pubmed
Jones,
Secreted Frizzled-related proteins: searching for relationships and patterns.
2002,
Pubmed
Katoh,
Comparative genomics on Wnt16 orthologs.
2005,
Pubmed
Katoh,
WNT/PCP signaling pathway and human cancer (review).
2005,
Pubmed
Kawano,
Secreted antagonists of the Wnt signalling pathway.
2003,
Pubmed
Kilian,
The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation.
2003,
Pubmed
Klein,
Planar cell polarization: an emerging model points in the right direction.
2005,
Pubmed
Kohn,
Wnt and calcium signaling: beta-catenin-independent pathways.
2005,
Pubmed
Kusserow,
Unexpected complexity of the Wnt gene family in a sea anemone.
2005,
Pubmed
Lee,
A WNT of things to come: evolution of Wnt signaling and polarity in cnidarians.
2006,
Pubmed
Leveugle,
Phylogenetic analysis of Ciona intestinalis gene superfamilies supports the hypothesis of successive gene expansions.
2004,
Pubmed
Logan,
The Wnt signaling pathway in development and disease.
2004,
Pubmed
Maloof,
A Wnt signaling pathway controls hox gene expression and neuroblast migration in C. elegans.
1999,
Pubmed
Mao,
LDL-receptor-related protein 6 is a receptor for Dickkopf proteins.
2001,
Pubmed
Mao,
Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling.
2002,
Pubmed
Marsal,
Gtwnt-5 a member of the wnt family expressed in a subpopulation of the nervous system of the planarian Girardia tigrina.
2003,
Pubmed
Miller,
The Wnts.
2002,
Pubmed
Mlodzik,
Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation?
2002,
Pubmed
Nusse,
WNT targets. Repression and activation.
1999,
Pubmed
Nusse,
An ancient cluster of Wnt paralogues.
2001,
Pubmed
Pongracz,
Wnt signalling in lung development and diseases.
2006,
Pubmed
Prud'homme,
Phylogenetic analysis of the Wnt gene family. Insights from lophotrochozoan members.
2002,
Pubmed
,
Echinobase
Ronquist,
MrBayes 3: Bayesian phylogenetic inference under mixed models.
2003,
Pubmed
Saitou,
The neighbor-joining method: a new method for reconstructing phylogenetic trees.
1987,
Pubmed
Sasakura,
Ascidian Wnt-5 gene is involved in the morphogenetic movement of notochord cells.
2001,
Pubmed
Schier,
Molecular genetics of axis formation in zebrafish.
2005,
Pubmed
Schubert,
A phylogenetic tree of the Wnt genes based on all available full-length sequences, including five from the cephalochordate amphioxus.
2000,
Pubmed
Semënov,
Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.
2001,
Pubmed
Shulman,
Frizzled signaling and the developmental control of cell polarity.
1998,
Pubmed
Stamatakis,
RAxML-III: a fast program for maximum likelihood-based inference of large phylogenetic trees.
2005,
Pubmed
Sullivan,
StellaBase: the Nematostella vectensis Genomics Database.
2006,
Pubmed
Tao,
Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos.
2005,
Pubmed
Thompson,
The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools.
1997,
Pubmed
Veeman,
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
2003,
Pubmed
Veeman,
Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements.
2003,
Pubmed
Wallingford,
Regulation of convergent extension in Xenopus by Wnt5a and Frizzled-8 is independent of the canonical Wnt pathway.
2001,
Pubmed
Wallingford,
Convergent extension: the molecular control of polarized cell movement during embryonic development.
2002,
Pubmed
Wang,
Wnt signaling, Ca2+, and cyclic GMP: visualizing Frizzled functions.
2003,
Pubmed
Wang,
Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5.
2005,
Pubmed
Whittaker,
The echinoderm adhesome.
2006,
Pubmed
,
Echinobase
Wikramanayake,
Nuclear beta-catenin-dependent Wnt8 signaling in vegetal cells of the early sea urchin embryo regulates gastrulation and differentiation of endoderm and mesodermal cell lineages.
2004,
Pubmed
,
Echinobase
Wu,
Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/beta-catenin signalling.
2001,
Pubmed
Wu,
Ligand receptor interactions in the Wnt signaling pathway in Drosophila.
2002,
Pubmed
Zorn,
Anterior endomesoderm specification in Xenopus by Wnt/beta-catenin and TGF-beta signalling pathways.
1999,
Pubmed
van Ooyen,
The nucleotide sequence of the human int-1 mammary oncogene; evolutionary conservation of coding and non-coding sequences.
1985,
Pubmed
