Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Dev Biol 2006 Dec 01;3001:180-93. doi: 10.1016/j.ydbio.2006.08.074.
Show Gene links Show Anatomy links

The sea urchin kinome: a first look.

Bradham CA , Foltz KR , Beane WS , Arnone MI , Rizzo F , Coffman JA , Mushegian A , Goel M , Morales J , Geneviere AM , Lapraz F , Robertson AJ , Kelkar H , Loza-Coll M , Townley IK , Raisch M , Roux MM , Lepage T , Gache C , McClay DR , Manning G .

This paper reports a preliminary in silico analysis of the sea urchin kinome. The predicted protein kinases in the sea urchin genome were identified, annotated and classified, according to both function and kinase domain taxonomy. The results show that the sea urchin kinome, consisting of 353 protein kinases, is closer to the Drosophila kinome (239) than the human kinome (518) with respect to total kinase number. However, the diversity of sea urchin kinases is surprisingly similar to humans, since the urchin kinome is missing only 4 of 186 human subfamilies, while Drosophila lacks 24. Thus, the sea urchin kinome combines the simplicity of a non-duplicated genome with the diversity of function and signaling previously considered to be vertebrate-specific. More than half of the sea urchin kinases are involved with signal transduction, and approximately 88% of the signaling kinases are expressed in the developing embryo. These results support the strength of this nonchordate deuterostome as a pivotal developmental and evolutionary model organism.

PubMed ID: 17027740
Article link: Dev Biol
Grant support: [+]

Genes referenced: LOC100887844