Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Echinobase
ECB-ART-39822
Mar Environ Res 2006 Jul 01;62 Suppl:S1-4. doi: 10.1016/j.marenvres.2006.04.062.
Show Gene links Show Anatomy links

The sea urchin embryo as a model for studying efflux transporters: roles and energy cost.

Epel D , Cole B , Hamdoun A , Thurber RV .


???displayArticle.abstract???
We describe the use of the sea urchin as a model for studying efflux transporters and estimating energy cost for the cytotoxin protective system provided by these transporters. The unfertilized egg has low transport activity, which increases to a new steady state shortly after fertilization. Activity results from p-glycoprotein (p-gp) and MRP type transporters which protect the embryo from cytotoxic drugs that can disrupt cell division or induce apoptosis. The energy cost is estimated from a novel use of calcein-AM as a substrate; keeping 0.25 microM substrate levels out of the cell utilizes only 0.023% of steady state respiration.

???displayArticle.pubmedLink??? 16740304
???displayArticle.pmcLink??? PMC3160780
???displayArticle.link??? Mar Environ Res
???displayArticle.grants??? [+]

Genes referenced: LOC100887844 LOC115919910 LOC582726

References [+] :
Essodaigui, Kinetic analysis of calcein and calcein-acetoxymethylester efflux mediated by the multidrug resistance protein and P-glycoprotein. 1998, Pubmed