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Planta Med 2006 Aug 01;7210:932-5. doi: 10.1055/s-2006-931603.
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Nobilisides A - C, three new triterpene glycosides from the sea cucumber Holothuria nobilis.

Wu J , Yi YH , Tang HF , Wu HM , Zou ZR , Lin HW .

Three new triterpene glycosides, named nobilisides A ( 1), B ( 2) and C ( 3), were isolated from the sea cucumber Holothuria nobilis Selenka. Their structures were deduced by extensive spectral analysis and chemical evidence. Compounds 1 and 3 are non-sulfated monoglycosides while 2 is a sulfated diglycoside. The presence of two conjugated double bonds [22 E,24-diene and 7,9(11)-diene] in the aglycone of 1 is a rare structural feature among sea cucumber glycosides, while 2 and 3 possess the same 22,25-epoxy moiety as their side chains. All three glycosides exhibited significant cytotoxicity against human tumor cell lines.

PubMed ID: 16732529
Article link: Planta Med

Genes referenced: LOC100887844 LOC100893907 LOC115919910