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Neurochem Res
2005 Jan 01;306-7:825-37. doi: 10.1007/s11064-005-6876-6.
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The pre-nervous serotonergic system of developing sea urchin embryos and larvae: pharmacologic and immunocytochemical evidence.
Buznikov GA
,
Peterson RE
,
Nikitina LA
,
Bezuglov VV
,
Lauder JM
.
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Forty serotonin-related neurochemicals were tested on embryos and larvae of Lytechinus variegatus and other sea urchin species. Some of these substances (agonists of 5-HT1 receptors, antagonists of 5-HT2, 5-HT3 or 5-HT4 receptors, and inhibitors of the serotonin transporter, SERT) perturbed post-blastulation development, eliciting changes in embryonic/larval phenotypes typical for each class of receptor ligand. These developmental malformations were prevented completely or partially by serotonin (5-HT) or 5-HT analogs (5-HTQ, AA-5-HT), providing evidence for the putative localization of cellular targets. Immunoreactive 5-HT, 5-HT receptors and SERT were found in pre-nervous embryos and larvae of both L. variegatus and Strongylocentrotus droebachiensis. During gastrulation, these components of the serotonergic system were localized to the archenteron (primary gut), mesenchyme-like cells, and often the apical ectoderm. These results provide evidence that pre-nervous 5-HT may regulate early events of sea urchin embryogenesis, mediated by 5-HT receptors or the 5-HT transporter.
Aloyo,
Selective and divergent regulation of cortical 5-HT(2A) receptors in rabbit.
2001, Pubmed
Aloyo,
Selective and divergent regulation of cortical 5-HT(2A) receptors in rabbit.
2001,
Pubmed
Anitole-Misleh,
Developmental regulation of catecholamine levels during sea urchin embryo morphogenesis.
2004,
Pubmed
,
Echinobase
Berry,
Rapid agonist-induced internalization of the 5-hydroxytryptamine2A receptor occurs via the endosome pathway in vitro.
1996,
Pubmed
Bhatnagar,
The dynamin-dependent, arrestin-independent internalization of 5-hydroxytryptamine 2A (5-HT2A) serotonin receptors reveals differential sorting of arrestins and 5-HT2A receptors during endocytosis.
2001,
Pubmed
Bonhaus,
The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors.
1995,
Pubmed
Buznikov,
From oocyte to neuron: do neurotransmitters function in the same way throughout development?
1996,
Pubmed
Buznikov,
Sea urchin embryos and larvae as biosensors for neurotoxicants.
2003,
Pubmed
,
Echinobase
Buznikov,
Serotonin and serotonin-like substances as regulators of early embryogenesis and morphogenesis.
2001,
Pubmed
,
Echinobase
Buznikov,
[Polyenic acid 5-hydroxytryptamides and 3-hydroxytyramides as tools for studying of the pre-nervous biogenic monoamine functions].
2000,
Pubmed
,
Echinobase
Candiani,
Immunocytochemical localization of serotonin in embryos, larvae and adults of the lancelet, Branchiostoma floridae.
2001,
Pubmed
Colas,
Serotonin synchronises convergent extension of ectoderm with morphogenetic gastrulation movements in Drosophila.
1999,
Pubmed
Colas,
Maternal and zygotic control of serotonin biosynthesis are both necessary for Drosophila germband extension.
1999,
Pubmed
Deguchi,
External Ca2+ is predominantly used for cytoplasmic and nuclear Ca2+ increases in fertilized oocytes of the marine bivalve Mactra chinensis.
2003,
Pubmed
Doran,
Effect of serotonin on ciliary beating and intracellular calcium concentration in identified populations of embryonic ciliary cells.
2004,
Pubmed
Fiorica-Howells,
Serotonin and the 5-HT(2B) receptor in the development of enteric neurons.
2000,
Pubmed
Forbes,
Synthesis, biological activity, and molecular modeling of selective 5-HT(2C/2B) receptor antagonists.
1996,
Pubmed
Gaspar,
The developmental role of serotonin: news from mouse molecular genetics.
2003,
Pubmed
Gray,
The interaction of a constitutively active arrestin with the arrestin-insensitive 5-HT(2A) receptor induces agonist-independent internalization.
2003,
Pubmed
Gustafson,
On the role of serotonin and acetylcholine in sea urchin morphogenesis.
1970,
Pubmed
,
Echinobase
Gutafson,
How genes control morphogenesis. The role of serotonin and acetylcholine in morphogenesis.
1971,
Pubmed
Hanley,
Mechanisms of ligand-induced desensitization of the 5-hydroxytryptamine(2A) receptor.
2002,
Pubmed
Hardin,
Commitment along the dorsoventral axis of the sea urchin embryo is altered in response to NiCl2.
1992,
Pubmed
,
Echinobase
Hay-Schmidt,
The evolution of the serotonergic nervous system.
2000,
Pubmed
,
Echinobase
Hoyer,
Molecular, pharmacological and functional diversity of 5-HT receptors.
2002,
Pubmed
Il'ková,
Serotonin localization and its functional significance during mouse preimplantation embryo development.
2004,
Pubmed
Katow,
The 5-HT receptor cell is a new member of secondary mesenchyme cell descendants and forms a major blastocoelar network in sea urchin larvae.
2004,
Pubmed
,
Echinobase
Kreiling,
Early development of the serotonergic and dopaminergic nervous system in Spisula solidissima (surf clam) larvae.
2001,
Pubmed
Lauder,
Neurotransmitters as growth regulatory signals: role of receptors and second messengers.
1993,
Pubmed
Levin,
A novel immunohistochemical method for evaluation of antibody specificity and detection of labile targets in biological tissue.
2004,
Pubmed
Pauwels,
Diverse signalling by 5-hydroxytryptamine (5-HT) receptors.
2000,
Pubmed
Pennati,
WAY-100635, an antagonist of 5-HT(1A) receptor, causes malformations of the CNS in ascidian embryos.
2003,
Pubmed
Raymond,
Immunohistochemical mapping of cellular and subcellular distribution of 5-HT1A receptors in rat and human kidneys.
1993,
Pubmed
Renaud,
On the role of serotonin and 5-methoxy-tryptamine in the regulation of cell division in sea urchin eggs.
1983,
Pubmed
,
Echinobase
Roth,
5-Hydroxytryptamine2-family receptors (5-hydroxytryptamine2A, 5-hydroxytryptamine2B, 5-hydroxytryptamine2C): where structure meets function.
1998,
Pubmed
Sheng,
A serotonin receptor antagonist induces oocyte maturation in both frogs and mice: evidence that the same G protein-coupled receptor is responsible for maintaining meiosis arrest in both species.
2005,
Pubmed
Sherwood,
LvNotch signaling mediates secondary mesenchyme specification in the sea urchin embryo.
1999,
Pubmed
,
Echinobase
Shmukler,
Action of serotonin antagonists on cytoplasmic calcium levels in early embryos of sea urchin Lytechinus pictus.
1999,
Pubmed
,
Echinobase
Stricker,
Multiple triggers of oocyte maturation in nemertean worms: the roles of calcium and serotonin.
2000,
Pubmed
Tierney,
Structure and function of invertebrate 5-HT receptors: a review.
2001,
Pubmed
Wallace,
Serotonin immunocytochemistry in the adult and developing rat brain: methodological and pharmacological considerations.
1982,
Pubmed
Wallace,
Monoamines in the early chick embryo: demonstration of serotonin synthesis and the regional distribution of serotonin-concentrating cells during morphogenesis.
1982,
Pubmed
Walther,
Serotonin synthesis in murine embryonic stem cells.
1999,
Pubmed
Wessel,
Sequential expression of germ-layer specific molecules in the sea urchin embryo.
1985,
Pubmed
,
Echinobase
Willins,
Serotonergic antagonist effects on trafficking of serotonin 5-HT2A receptors in vitro and in vivo.
1998,
Pubmed
Xia,
A direct interaction of PSD-95 with 5-HT2A serotonin receptors regulates receptor trafficking and signal transduction.
2003,
Pubmed
Yaguchi,
Initial analysis of immunochemical cell surface properties, location and formation of the serotonergic apical ganglion in sea urchin embryos.
2000,
Pubmed
,
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