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ECB-ART-37556
J Biol Chem 2000 Dec 01;27548:38005-11. doi: 10.1074/jbc.M005948200.
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Roles of two homotetrameric kinesins in sea urchin embryonic cell division.

Chui KK , Rogers GC , Kashina AM , Wedaman KP , Sharp DJ , Nguyen DT , Wilt F , Scholey JM .


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To improve our understanding of the roles of microtubule cross-linking motors in mitosis, we analyzed two sea urchin embryonic kinesin-related proteins. It is striking to note that both of these proteins behave as homotetramers, but one behaves as a more compact molecule than the other. These observations suggest that these two presumptive motors could cross-link microtubules into bundles with different spacing. Both motors localize to mitotic spindles, and antibody microinjection experiments suggest that they have mitotic functions. Thus, one of these kinesin-related proteins may cross-link spindle microtubules into loose bundles that are "tightened" by the other.

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Genes referenced: kif23 LOC100887844 LOC115919910
???displayArticle.antibodies??? kif11 Ab1 kif23 Ab1 kif23 Ab2