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Echinobase
ECB-ART-37114
Biochem Biophys Res Commun 1999 Mar 05;2561:177-83. doi: 10.1006/bbrc.1999.0309.
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Tctex2-related outer arm dynein light chain is phosphorylated at activation of sperm motility.

Inaba K , Kagami O , Ogawa K .


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When the motility of sperm is activated, only one light chain of flagellar outer arm dynein is phosphorylated in many organisms. We show here that the light chain to be phosphorylated was shown to be light chain 2 (LC2) in rainbow trout and chum salmon sperm and LC1 in sea urchin sperm. Molecular analyses of the phosphorylated light chains from sperm flagella of the salmonid fishes and sea urchin revealed that the light chains are homologs of the mouse t complex-encoded protein Tctex2, which is one of the putative t complex distorters. These results suggest that mouse Tctex2 might also be a light chain of flagellar outer arm dynein and that the abortive phosphorylation of Tctex2/outer arm dynein light chain might be related to the less progressive movement of sperm.

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Genes referenced: dnah3 LOC100887844 LOC591043