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Proc Natl Acad Sci U S A
1993 Oct 01;9019:9115-9. doi: 10.1073/pnas.90.19.9115.
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Fascin, an echinoid actin-bundling protein, is a homolog of the Drosophila singed gene product.
Bryan J
,
Edwards R
,
Matsudaira P
,
Otto J
,
Wulfkuhle J
.
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A cDNA for fascin, an actin-bundling protein in echinoderms, has been cloned, sequenced, and expressed. The predicted mass of the protein is approximately 55 kDa, similar to that observed for fascin purified from sea urchin eggs. Bacterially expressed fascin reacts with antibodies prepared against sea urchin egg fascin. Fascin has a strong sequence similarity to the singed gene (sn) product in Drosophila and has similarities with a 55-kDa human actin-bundling protein. No extensive similarities were found with other known actin-binding/bundling proteins, indicating that this is a separate gene family.
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Arpin,
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Bazari,
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1988,
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Bryan,
Separation and interaction of the major components of sea urchin actin gel.
1978,
Pubmed
,
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Burgess,
Polarized bundles of actin filaments within microvilli of fertilized sea urchin eggs.
1977,
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,
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Cooley,
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1992,
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DeRosier,
Structure of actin-containing filaments from two types of non-muscle cells.
1977,
Pubmed
,
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DeRosier,
Structure of F-actin needles from extracts of sea urchin oocytes.
1981,
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,
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Fechheimer,
Isolation and sequencing of cDNA clones encoding the Dictyostelium discoideum 30,000-dalton actin-bundling protein.
1991,
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Gorlin,
Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring.
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Gutzeit,
The role of microfilaments in cytoplasmic streaming in Drosophila follicles.
1986,
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Kane,
Preparation and purification of polymerized actin from sea urchin egg extracts.
1975,
Pubmed
,
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Laemmli,
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
1970,
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Maekawa,
A protein in starfish sperm head which bundles actin filaments in vitro: purification and characterization.
1982,
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,
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Matsudaira,
Modular organization of actin crosslinking proteins.
1991,
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Otto,
Formation of filopodia in coelomocytes: localization of fascin, a 58,000 dalton actin cross-linking protein.
1979,
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,
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Otto,
Redistribution of actin and fascin in sea urchin eggs after fertilization.
1980,
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,
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Otto,
Assembly-disassembly of actin bundles in starfish oocytes: an analysis of actin-associated proteins in the isolated cortex.
1984,
Pubmed
,
Echinobase
Overton,
The fine structure of developing bristles in wild type and mutant Drosophila melanogaster.
1967,
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Paterson,
Structure and transcription of the singed locus of Drosophila melanogaster.
1991,
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Roiha,
P element insertions and rearrangements at the singed locus of Drosophila melanogaster.
1988,
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Scheel,
Hisactophilin, a histidine-rich actin-binding protein from Dictyostelium discoideum.
1989,
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Smith,
Automatic generation of primary sequence patterns from sets of related protein sequences.
1990,
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Spudich,
Structure of actin filament bundles from microvilli of sea urchin eggs.
1979,
Pubmed
,
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Studier,
Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes.
1986,
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Xue,
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1993,
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Yamashiro-Matsumura,
Intracellular localization of the 55-kD actin-bundling protein in cultured cells: spatial relationships with actin, alpha-actinin, tropomyosin, and fimbrin.
1986,
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Yamashiro-Matsumura,
Purification and characterization of an F-actin-bundling 55-kilodalton protein from HeLa cells.
1985,
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de Arruda,
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