Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Proc Natl Acad Sci U S A 1993 Oct 01;9019:9115-9. doi: 10.1073/pnas.90.19.9115.
Show Gene links Show Anatomy links

Fascin, an echinoid actin-bundling protein, is a homolog of the Drosophila singed gene product.

Bryan J , Edwards R , Matsudaira P , Otto J , Wulfkuhle J .

A cDNA for fascin, an actin-bundling protein in echinoderms, has been cloned, sequenced, and expressed. The predicted mass of the protein is approximately 55 kDa, similar to that observed for fascin purified from sea urchin eggs. Bacterially expressed fascin reacts with antibodies prepared against sea urchin egg fascin. Fascin has a strong sequence similarity to the singed gene (sn) product in Drosophila and has similarities with a 55-kDa human actin-bundling protein. No extensive similarities were found with other known actin-binding/bundling proteins, indicating that this is a separate gene family.

PubMed ID: 8415664
PMC ID: PMC47512
Article link: Proc Natl Acad Sci U S A
Grant support: [+]

Genes referenced: FSCN1 LOC100887844 LOC590297
Antibodies: FSCN1 Ab1

References [+] :
Arpin, Sequence of human villin: a large duplicated domain homologous with other actin-severing proteins and a unique small carboxy-terminal domain related to villin specificity. 1988, Pubmed