Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Echinobase
ECB-ART-31849
Dev Biol 1989 Jun 01;1332:605-8. doi: 10.1016/0012-1606(89)90063-8.
Show Gene links Show Anatomy links

Pertussis toxin inhibits 1-methyladenine-induced maturation in starfish oocytes.

Shilling F , Chiba K , Hoshi M , Kishimoto T , Jaffe LA .


???displayArticle.abstract???
Starfish oocytes injected with pertussis toxin (3-6 micrograms/ml) or its catalytically active A-subunit (1 microgram/ml) did not undergo germinal vesicle breakdown in response to 1-methyladenine (1-10 microM). The pertussis block could be bypassed by transfer of cytoplasm that contained maturation-promoting factor (MPF). After insemination, pertussis-blocked, MPF-rescued oocytes underwent cortical vesicle exocytosis and cleavage. These results suggest the involvement of a pertussis sensitive G-protein in the pathway coupling 1-methyladenine action at the cell surface to the reinitiation of meiosis.

???displayArticle.pubmedLink??? 2499496
???displayArticle.link??? Dev Biol
???displayArticle.grants??? [+]

Genes referenced: LOC115919910