Echinobase will be undergoing a hardware update June 13 and 14, 2023 and therefore will be unavailable those days.

We apologize for the inconvenience.

Click on this message to dismiss it.
Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Drugs Exp Clin Res 1988 Jan 01;1412:723-8.
Show Gene links Show Anatomy links

Calyculins, potent antitumour metabolites from the marine sponge Discodermia calyx: biological activities.

Kato Y , Fusetani N , Matsunaga S , Hashimoto K .

Calyculins A-D, extraordinary metabolites of the Japanese marine sponge Discodermia calyx, showed marked cytotoxicity against murine leukaemia cells and echinoderm embryos. The major compound, calyculin A, also had potent antitumour activity, although it was highly toxic in mice. Its mode of action in L1210, rat fibroblasts and fertilized sea urchin eggs has been studied, which led the authors to predict that calyculins affect primarily a system other than macromolecular syntheses.

PubMed ID: 2472940
Article link:

Genes referenced: LOC100887844 LOC591473