Dev Comp Immunol 1985 Jan 01;94:597-603. doi: 10.1016/0145-305x(85)90025-4.

Sensitization and histamine release by cells of the sand dollar, Mellita quinquiesperforata.

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The coelomic fluid of the sand dollar, Mellita quinquiesperforata, contains cells (coelomocytes) that release red granules when the animal is stressed. Preliminary evidence suggests that the red pigment is protective, but its release from the coelomocytes is similar to that of allergy-inducing mediators from mammalian basophils and mast cells. The present study revealed further links with allergy, e.g., the coelomocytes can be sensitized to foreign proteins and release histamine on challenge. These and other findings suggest that the coelomocyte stress response may be an evolutionary precursor to the mammalian allergic response.

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