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Nature
2010 Jan 25;4637284:1084-8. doi: 10.1038/nature08744.
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Ancient animal microRNAs and the evolution of tissue identity.
Christodoulou F, Raible F, Tomer R, Simakov O, Trachana K, Klaus S, Snyman H, Hannon GJ, Bork P, Arendt D.
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The spectacular escalation in complexity in early bilaterian evolution correlates with a strong increase in the number of microRNAs. To explore the link between the birth of ancient microRNAs and body plan evolution, we set out to determine the ancient sites of activity of conserved bilaterian microRNA families in a comparative approach. We reason that any specific localization shared between protostomes and deuterostomes (the two major superphyla of bilaterian animals) should probably reflect an ancient specificity of that microRNA in their last common ancestor. Here, we investigate the expression of conserved bilaterian microRNAs in Platynereis dumerilii, a protostome retaining ancestral bilaterian features, in Capitella, another marine annelid, in the sea urchin Strongylocentrotus, a deuterostome, and in sea anemone Nematostella, representing an outgroup to the bilaterians. Our comparative data indicate that the oldest known animal microRNA, miR-100, and the related miR-125 and let-7 were initially active in neurosecretory cells located around the mouth. Other sets of ancient microRNAs were first present in locomotor ciliated cells, specific brain centres, or, more broadly, one of four major organ systems: central nervous system, sensory tissue, musculature and gut. These findings reveal that microRNA evolution and the establishment of tissue identities were closely coupled in bilaterian evolution. Also, they outline a minimum set of cell types and tissues that existed in the protostome-deuterostome ancestor.
Aboobaker,
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Aboobaker,
Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development.
2005,
Pubmed Arenas-Mena,
Spatial expression of Hox cluster genes in the ontogeny of a sea urchin.
2000,
Pubmed
,
Echinobase Arendt,
Evolution of the bilaterian larval foregut.
2001,
Pubmed Caygill,
Temporal regulation of metamorphic processes in Drosophila by the let-7 and miR-125 heterochronic microRNAs.
2008,
Pubmed Denes,
Molecular architecture of annelid nerve cord supports common origin of nervous system centralization in bilateria.
2007,
Pubmed Deo,
Detection of mammalian microRNA expression by in situ hybridization with RNA oligonucleotides.
2006,
Pubmed Farh,
The widespread impact of mammalian MicroRNAs on mRNA repression and evolution.
2005,
Pubmed González-Estévez,
Diverse miRNA spatial expression patterns suggest important roles in homeostasis and regeneration in planarians.
2009,
Pubmed Grimson,
Early origins and evolution of microRNAs and Piwi-interacting RNAs in animals.
2008,
Pubmed Harada,
Developmental expression of the hemichordate otx ortholog.
2000,
Pubmed Jékely,
Cellular resolution expression profiling using confocal detection of NBT/BCIP precipitate by reflection microscopy.
2007,
Pubmed Kapsimali,
MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system.
2007,
Pubmed Pasquinelli,
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA.
2000,
Pubmed Pfeffer,
Identification of microRNAs of the herpesvirus family.
2005,
Pubmed Poy,
A pancreatic islet-specific microRNA regulates insulin secretion.
2004,
Pubmed Prochnik,
Evidence for a microRNA expansion in the bilaterian ancestor.
2007,
Pubmed Raible,
Vertebrate-type intron-rich genes in the marine annelid Platynereis dumerilii.
2005,
Pubmed Rao,
Myogenic factors that regulate expression of muscle-specific microRNAs.
2006,
Pubmed Reinhart,
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans.
2000,
Pubmed Rentzsch,
Asymmetric expression of the BMP antagonists chordin and gremlin in the sea anemone Nematostella vectensis: implications for the evolution of axial patterning.
2006,
Pubmed Scholz,
The ancestral role of Brachyury: expression of NemBra1 in the basal cnidarian Nematostella vectensis (Anthozoa).
2003,
Pubmed Shkumatava,
Coherent but overlapping expression of microRNAs and their targets during vertebrate development.
2009,
Pubmed Sokol,
Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis.
2008,
Pubmed Sood,
Cell-type-specific signatures of microRNAs on target mRNA expression.
2006,
Pubmed Szafranska,
MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma.
2007,
Pubmed Tessmar-Raible,
Conserved sensory-neurosecretory cell types in annelid and fish forebrain: insights into hypothalamus evolution.
2007,
Pubmed Vígh,
The system of cerebrospinal fluid-contacting neurons. Its supposed role in the nonsynaptic signal transmission of the brain.
2004,
Pubmed Wheeler,
The deep evolution of metazoan microRNAs.
2009,
Pubmed Wienholds,
MicroRNA expression in zebrafish embryonic development.
2005,
Pubmed
