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A global scan of transcription factor usage in the sea urchin embryo was carried out in the context of the Strongylocentrotus purpuratus genome sequencing project, and results from six individual studies are here considered. Transcript prevalence data were obtained for over 280 regulatory genes encoding sequence-specific transcription factors of every known family, but excluding genes encoding zinc finger proteins. This is a statistically inclusive proxy for the total "regulome" of the sea urchin genome. Close to 80% of the regulome is expressed at significant levels by the late gastrula stage. Most regulatory genes must be used repeatedly for different functions as development progresses. An evolutionary implication is that animal complexity at the stage when the regulome first evolved was far simpler than even the last common bilaterian ancestor, and is thus of deep antiquity.
Amore,
Spdeadringer, a sea urchin embryo gene required separately in skeletogenic and oral ectoderm gene regulatory networks.
2003, Pubmed,
Echinobase
Amore,
Spdeadringer, a sea urchin embryo gene required separately in skeletogenic and oral ectoderm gene regulatory networks.
2003,
Pubmed
,
Echinobase Angerer,
Sea urchin goosecoid function links fate specification along the animal-vegetal and oral-aboral embryonic axes.
2001,
Pubmed
,
Echinobase Arenas-Mena,
Spatial expression of Hox cluster genes in the ontogeny of a sea urchin.
2000,
Pubmed
,
Echinobase Arenas-Mena,
Expression of the Hox gene complex in the indirect development of a sea urchin.
1998,
Pubmed
,
Echinobase Aris-Brosou,
Bayesian models of episodic evolution support a late precambrian explosive diversification of the Metazoa.
2003,
Pubmed Arnone,
Genetic organization and embryonic expression of the ParaHox genes in the sea urchin S. purpuratus: insights into the relationship between clustering and colinearity.
2006,
Pubmed
,
Echinobase Bolouri,
Transcriptional regulatory cascades in development: initial rates, not steady state, determine network kinetics.
2003,
Pubmed
,
Echinobase Calzone,
Developmental appearance of factors that bind specifically to cis-regulatory sequences of a gene expressed in the sea urchin embryo.
1988,
Pubmed
,
Echinobase Chen,
Small bilaterian fossils from 40 to 55 million years before the cambrian.
2004,
Pubmed Chen,
Precambrian animal diversity: putative phosphatized embryos from the Doushantuo Formation of China.
2000,
Pubmed Chen,
Phosphatized polar lobe-forming embryos from the Precambrian of southwest China.
2006,
Pubmed Davidson,
How embryos work: a comparative view of diverse modes of cell fate specification.
1990,
Pubmed
,
Echinobase Davidson,
A genomic regulatory network for development.
2002,
Pubmed
,
Echinobase Douzery,
The timing of eukaryotic evolution: does a relaxed molecular clock reconcile proteins and fossils?
2004,
Pubmed Erwin,
The last common bilaterian ancestor.
2002,
Pubmed Howard,
cis-Regulatory control circuits in development.
2004,
Pubmed
,
Echinobase Howard-Ashby,
Gene families encoding transcription factors expressed in early development of Strongylocentrotus purpuratus.
2006,
Pubmed
,
Echinobase Howard-Ashby,
Identification and characterization of homeobox transcription factor genes in Strongylocentrotus purpuratus, and their expression in embryonic development.
2006,
Pubmed
,
Echinobase Knight,
Identification of conserved C2H2 zinc-finger gene families in the Bilateria.
2001,
Pubmed Koide,
Xenopus as a model system to study transcriptional regulatory networks.
2005,
Pubmed
,
Echinobase Laity,
Zinc finger proteins: new insights into structural and functional diversity.
2001,
Pubmed Levine,
Gene regulatory networks for development.
2005,
Pubmed
,
Echinobase Livi,
Expression and function of blimp1/krox, an alternatively transcribed regulatory gene of the sea urchin endomesoderm network.
2006,
Pubmed
,
Echinobase Loose,
A genetic regulatory network for Xenopus mesendoderm formation.
2004,
Pubmed
,
Echinobase Lu,
Crystal structure of a zinc-finger-RNA complex reveals two modes of molecular recognition.
2003,
Pubmed Martindale,
Investigating the origins of triploblasty: 'mesodermal' gene expression in a diploblastic animal, the sea anemone Nematostella vectensis (phylum, Cnidaria; class, Anthozoa).
2004,
Pubmed Materna,
The C2H2 zinc finger genes of Strongylocentrotus purpuratus and their expression in embryonic development.
2006,
Pubmed
,
Echinobase Oliveri,
Gene regulatory network controlling embryonic specification in the sea urchin.
2004,
Pubmed
,
Echinobase Otim,
SpHnf6, a transcription factor that executes multiple functions in sea urchin embryogenesis.
2004,
Pubmed
,
Echinobase Peterson,
Estimating metazoan divergence times with a molecular clock.
2004,
Pubmed Peterson,
Set-aside cells in maximal indirect development: evolutionary and developmental significance.
1997,
Pubmed Peterson,
Origin of the Eumetazoa: testing ecological predictions of molecular clocks against the Proterozoic fossil record.
2005,
Pubmed Rizzo,
Identification and developmental expression of the ets gene family in the sea urchin (Strongylocentrotus purpuratus).
2006,
Pubmed
,
Echinobase Samanta,
The transcriptome of the sea urchin embryo.
2006,
Pubmed
,
Echinobase Seipel,
Evolution of striated muscle: jellyfish and the origin of triploblasty.
2005,
Pubmed Sodergren,
The genome of the sea urchin Strongylocentrotus purpuratus.
2006,
Pubmed
,
Echinobase Song,
Oogenesis: single cell development and differentiation.
2006,
Pubmed
,
Echinobase Stathopoulos,
Genomic regulatory networks and animal development.
2005,
Pubmed Tu,
Sea urchin Forkhead gene family: phylogeny and embryonic expression.
2006,
Pubmed
,
Echinobase Xiao,
Fossil preservation in the Neoproterozoic Doushantuo phosphorite Lagerstatte, South China.
1999,
Pubmed Yuh,
Cis-regulatory logic in the endo16 gene: switching from a specification to a differentiation mode of control.
2001,
Pubmed
,
Echinobase Yuh,
Patchy interspecific sequence similarities efficiently identify positive cis-regulatory elements in the sea urchin.
2002,
Pubmed
,
Echinobase Yuh,
Brn1/2/4, the predicted midgut regulator of the endo16 gene of the sea urchin embryo.
2005,
Pubmed
,
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