Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Mol Cell Biol
1997 Mar 01;173:1189-200. doi: 10.1128/MCB.17.3.1189.
Show Gene links
Show Anatomy links
The five cleavage-stage (CS) histones of the sea urchin are encoded by a maternally expressed family of replacement histone genes: functional equivalence of the CS H1 and frog H1M (B4) proteins.
Mandl B
,
Brandt WF
,
Superti-Furga G
,
Graninger PG
,
Birnstiel ML
,
Busslinger M
.
???displayArticle.abstract???
The cleavage-stage (CS) histones of the sea urchin are known to be maternally expressed in the egg, have been implicated in chromatin remodeling of the male pronucleus following fertilization, and are the only histone variants present in embryonic chromatin up to the four-cell stage. With the help of partial peptide sequence information, we have isolated and identified CS H1, H2A, H2B, H3, and H4 cDNAs from egg poly(A)+ mRNA of the sea urchin Psammechinus miliaris. All five CS proteins correspond to replacement histone variants which are encoded by replication-independent genes containing introns, poly(A) addition signals, and long nontranslated sequences. Transcripts of the CS histone genes could be detected only during oogenesis and in development up to the early blastula stage. The CS proteins, with the exception of H4, are unique histones which are distantly related in sequence to the early, late, and sperm histone subtypes of the sea urchin. In contrast, the CS H1 protein displays highest sequence homology with the H1M (B4) histone of Xenopus laevis. Both H1 proteins are replacement histone variants with very similar developmental expression profiles in their respective species, thus indicating that the frog H1M (B4) gene is a vertebrate homolog of the CS H1 gene. These data furthermore suggest that the CS histones are of ancient evolutionary origin and may perform similar conserved functions during oogenesis and early development in different species.
Arents,
Topography of the histone octamer surface: repeating structural motifs utilized in the docking of nucleosomal DNA.
1993, Pubmed
Arents,
Topography of the histone octamer surface: repeating structural motifs utilized in the docking of nucleosomal DNA.
1993,
Pubmed
Arents,
The histone fold: a ubiquitous architectural motif utilized in DNA compaction and protein dimerization.
1995,
Pubmed
Arents,
The nucleosomal core histone octamer at 3.1 A resolution: a tripartite protein assembly and a left-handed superhelix.
1991,
Pubmed
Benttinen,
Early and late histones during sea urchin development.
1971,
Pubmed
,
Echinobase
Birnstiel,
Transcription termination and 3' processing: the end is in site!
1985,
Pubmed
Bouvet,
Specific regulation of Xenopus chromosomal 5S rRNA gene transcription in vivo by histone H1.
1994,
Pubmed
Brush,
Replacement variant histone genes contain intervening sequences.
1985,
Pubmed
Busslinger,
An unusual evolutionary behaviour of a sea urchin histone gene cluster.
1982,
Pubmed
,
Echinobase
Busslinger,
Regulation of histone gene expression.
1985,
Pubmed
,
Echinobase
Busslinger,
A regulatory sequence near the 3' end of sea urchin histone genes.
1979,
Pubmed
,
Echinobase
Busslinger,
Synthesis of sperm and late histone cDNAs of the sea urchin with a primer complementary to the conserved 3' terminal palindrome: evidence for tissue-specific and more general histone gene variants.
1985,
Pubmed
,
Echinobase
Carroll,
Changes in the histones of the sea urchin Stronglylocentrotus purpuratus at fertilization.
1979,
Pubmed
,
Echinobase
Cerf,
Homo- and heteronuclear two-dimensional NMR studies of the globular domain of histone H1: full assignment, tertiary structure, and comparison with the globular domain of histone H5.
1994,
Pubmed
Chamberlain,
Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate.
1979,
Pubmed
Childs,
Sea urchin (lytechinus pictus) late-stage histone H3 and H4 genes: characterization and mapping of a clustered but nontandemly linked multigene family.
1982,
Pubmed
,
Echinobase
Chirgwin,
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.
1979,
Pubmed
Cho,
Xenopus laevis B4, an intron-containing oocyte-specific linker histone-encoding gene.
1994,
Pubmed
Church,
Genomic sequencing.
1984,
Pubmed
Cohen,
Stage-specific switches in histone synthesis during embryogenesis of the sea urchin.
1975,
Pubmed
,
Echinobase
Dalton,
Transcription from the intron-containing chicken histone H2A.F gene is not S-phase regulated.
1989,
Pubmed
DeLeon,
Most early-variant histone mRNA is contained in the pronucleus of sea urchin eggs.
1983,
Pubmed
,
Echinobase
Dimitrov,
Chromatin transitions during early Xenopus embryogenesis: changes in histone H4 acetylation and in linker histone type.
1993,
Pubmed
Dimitrov,
Remodeling somatic nuclei in Xenopus laevis egg extracts: molecular mechanisms for the selective release of histones H1 and H1(0) from chromatin and the acquisition of transcriptional competence.
1996,
Pubmed
Dimitrov,
Remodeling sperm chromatin in Xenopus laevis egg extracts: the role of core histone phosphorylation and linker histone B4 in chromatin assembly.
1994,
Pubmed
Dworkin-Rastl,
The maternal histone H1 variant, H1M (B4 protein), is the predominant H1 histone in Xenopus pregastrula embryos.
1994,
Pubmed
Ernst,
Characterization of a cDNA clone coding for a sea urchin histone H2A variant related to the H2A.F/Z histone protein in vertebrates.
1987,
Pubmed
,
Echinobase
Green,
Phosphorylation of sea urchin histone CS H2A.
1989,
Pubmed
,
Echinobase
Green,
Interaction of sperm histone variants and linker DNA during spermiogenesis in the sea urchin.
1988,
Pubmed
,
Echinobase
Green,
Phosphorylation of sea urchin sperm H1 and H2B histones precedes chromatin decondensation and H1 exchange during pronuclear formation.
1985,
Pubmed
,
Echinobase
Gubler,
A simple and very efficient method for generating cDNA libraries.
1983,
Pubmed
Hatch,
Sequence of cDNAs for mammalian H2A.Z, an evolutionarily diverged but highly conserved basal histone H2A isoprotein species.
1988,
Pubmed
,
Echinobase
Hentschel,
The organization and expression of histone gene families.
1981,
Pubmed
Herlands,
Translational regulation of histone synthesis in the sea urchin strongylocentrotus purpuratus.
1982,
Pubmed
,
Echinobase
Hill,
Histone-DNA interactions and their modulation by phosphorylation of -Ser-Pro-X-Lys/Arg- motifs.
1991,
Pubmed
,
Echinobase
Hock,
Absence of somatic histone H1 in oocytes and preblastula embryos of Xenopus laevis.
1993,
Pubmed
Kandolf,
The H1A histone variant is an in vivo repressor of oocyte-type 5S gene transcription in Xenopus laevis embryos.
1994,
Pubmed
Kemler,
Characterization of two nonallelic pairs of late histone H2A and H2B genes of the sea urchin: differential regulation in the embryo and tissue-specific expression in the adult.
1986,
Pubmed
,
Echinobase
Kleinschmidt,
DNA-dependent phosphorylation of histone H2A.X during nucleosome assembly in Xenopus laevis oocytes: involvement of protein phosphorylation in nucleosome spacing.
1991,
Pubmed
Knowles,
Isolation, characterization, and expression of the gene encoding the late histone subtype H1-gamma of the sea urchin Strongylocentrotus purpuratus.
1987,
Pubmed
,
Echinobase
Lai,
Characterization of the structure and transcriptional patterns of the gene encoding the late histone subtype H1-beta of the sea urchin Strongylocentrotus purpuratus.
1988,
Pubmed
,
Echinobase
Lieber,
A histone H1 protein in sea urchins is encoded by a poly(A)+ mRNA.
1988,
Pubmed
,
Echinobase
Mauron,
Accumulation of individual histone mRNAs during embryogenesis of the sea urchin Strongylocentrotus purpuratus.
1982,
Pubmed
,
Echinobase
Maxson,
Expression and organization of histone genes.
1983,
Pubmed
,
Echinobase
Maxson,
Expression of maternal and paternal histone genes during early cleavage stages of the echinoderm hybrid Strongylocentrotus purpuratus x Lytechinus pictus.
1980,
Pubmed
,
Echinobase
Newrock,
Stage-specific mRNAs coding for subtypes of H2A and H2B histones in the sea urchin embryo.
1978,
Pubmed
,
Echinobase
Newrock,
Histone changes during chromatin remodeling in embryogenesis.
1978,
Pubmed
,
Echinobase
Nightingale,
Evidence for a shared structural role for HMG1 and linker histones B4 and H1 in organizing chromatin.
1996,
Pubmed
Ohsumi,
Occurrence of H1 subtypes specific to pronuclei and cleavage-stage cell nuclei of anuran amphibians.
1991,
Pubmed
Pehrson,
The fate of the small micromeres in sea urchin development.
1986,
Pubmed
,
Echinobase
Poccia,
Transitions in histone variants during sea urchin spermatogenesis.
1987,
Pubmed
,
Echinobase
Poccia,
Remodeling of sperm chromatin following fertilization: nucleosome repeat length and histone variant transitions in the absence of DNA synthesis.
1984,
Pubmed
,
Echinobase
Poccia,
RNA synthesis in male pronuclei of the sea urchin.
1985,
Pubmed
,
Echinobase
Poccia,
Packaging and unpackaging the sea urchin sperm genome.
1992,
Pubmed
,
Echinobase
Ramakrishnan,
Crystal structure of globular domain of histone H5 and its implications for nucleosome binding.
1993,
Pubmed
Roberts,
Sequence comparisons of non-allelic late histone genes and their early stage counterparts. Evidence for gene conversion within the sea urchin late stage gene family.
1984,
Pubmed
,
Echinobase
Salik,
Electrophoretic analysis of the stored histone pool in unfertilized sea urchin eggs: quantification and identification by antibody binding.
1981,
Pubmed
,
Echinobase
Savić,
Alterations in chromatin structure during early sea urchin embryogenesis.
1981,
Pubmed
,
Echinobase
Schaffner,
Genes and spacers of cloned sea urchin histone DNA analyzed by sequencing.
1978,
Pubmed
,
Echinobase
Shen,
Linker histone H1 regulates specific gene expression but not global transcription in vivo.
1996,
Pubmed
Smith,
Expression of a histone H1-like protein is restricted to early Xenopus development.
1988,
Pubmed
Strickland,
The primary structure of histone H1 from sperm of the sea urchin Parechinus angulosus. 2. Sequence of the C-terminal CNBr peptide and the entire primary structure.
1980,
Pubmed
,
Echinobase
Ura,
Differential association of HMG1 and linker histones B4 and H1 with dinucleosomal DNA: structural transitions and transcriptional repression.
1996,
Pubmed
van Daal,
Drosophila has a single copy of the gene encoding a highly conserved histone H2A variant of the H2A.F/Z type.
1988,
Pubmed
,
Echinobase
Vitelli,
Developmental regulation of micro-injected histone genes in sea urchin embryos.
1988,
Pubmed
,
Echinobase
Wells,
A comprehensive compilation and alignment of histones and histone genes.
1989,
Pubmed
Wells,
Structure of a human histone cDNA: evidence that basally expressed histone genes have intervening sequences and encode polyadenylylated mRNAs.
1985,
Pubmed
White,
Localization and expression of mRNA for a macronuclear-specific histone H2A variant (hv1) during the cell cycle and conjugation of Tetrahymena thermophila.
1988,
Pubmed
White,
Sequence and properties of the message encoding Tetrahymena hv1, a highly evolutionarily conserved histone H2A variant that is associated with active genes.
1988,
Pubmed
,
Echinobase
Wrighton,
Direct transcriptional stimulation of the ornithine decarboxylase gene by Fos in PC12 cells but not in fibroblasts.
1993,
Pubmed
Wu,
Separation of basal histone synthesis from S-phase histone synthesis in dividing cells.
1981,
Pubmed
Wu,
Patterns of histone variant synthesis can distinguish G0 from G1 cells.
1982,
Pubmed
