Dr. Jonathan M Scholey
Cell Biology: Motor Proteins in Mitosis and Ciliogenesis. Specific Projects: 1. Mechanisms of mitosis and chromosome segregation in Drosophila and sea urchin embryos, notably bipolar kinesin-5 motors and the sliding filament mechanism of mitotic spindle elongation during anaphase (funded by NIH grant GM55507): 2. Intraflagellar transport (IFT) motors, notably heterotrimeric/homodimeric kinesin-2 and IFT-dynein, in IFT and cilium biogenesis in C. elegans sensory neurons and sea urchin swimming blastulae (funded by NIH grant GM50718). Technical approaches; protein/nucleotide biochemistry and molecular biology; motor protein purification and motility/gliding assays; quantitative modelling (led by Dr G Civelekoglu-Scholey); and live cell light microscopy combined with the use of antibody inhibition, mutant analysis and RNA interference to elucidate motor protein/polymer dynamics and function in living C. elegans ciliated neurons, sea urchin blastomeres and Drosophila embryonic cells.
Lab MembershipsScholey Lab (Principal Investigator/Director)
UC Davis College of Biological Sciences
3253 Life Sciences
Web Page: https://scholeylab.faculty.ucdavis.edu/