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Profile Publications(38)
ECB-PERS-4200


Dr.  Jonathan M Scholey

Position

Professor Emeritus

Research Description

Cell Biology: Motor Proteins in Mitosis and Ciliogenesis.

Specific Projects: 1. Mechanisms of mitosis and chromosome segregation in Drosophila and sea urchin embryos, notably bipolar kinesin-5 motors and the sliding filament mechanism of mitotic spindle elongation during anaphase (funded by NIH grant GM55507): 2. Intraflagellar transport (IFT) motors, notably heterotrimeric/homodimeric kinesin-2 and IFT-dynein, in IFT and cilium biogenesis in C. elegans sensory neurons and sea urchin swimming blastulae (funded by NIH grant GM50718). Technical approaches; protein/nucleotide biochemistry and molecular biology; motor protein purification and motility/gliding assays; quantitative modelling (led by Dr G Civelekoglu-Scholey); and live cell light microscopy combined with the use of antibody inhibition, mutant analysis and RNA interference to elucidate motor protein/polymer dynamics and function in living C. elegans ciliated neurons, sea urchin blastomeres and Drosophila embryonic cells.

Lab Memberships

Scholey Lab (Principal Investigator/Director)


Contact

Address:
UC Davis College of Biological Sciences
3253 Life Sciences
Hutchison Dr
Davis, CA
95616, USA

Email: jmscholey@ucdavis.edu

Web Page: https://scholeylab.faculty.ucdavis.edu/

Phone:  530-304-0744