cytokinesis, endocytosis, exocytosis, axonal transport, translocate, echinoderm, ascidian eggs, aste
Our laboratory’s research is in a sub-area of cell biology. Specifically, we are interested in how cells change shape or form and how that is precisely regulated using the cytoskeleton. Molecular motors using cytoskeletal tracks are required for such intracellular movements as cytokinesis, endocytosis, exocytosis, axonal transport and organellar movement in general. Although motors are required, many relatively basic questions are unanswered. Our laboratory is now focusing on the study of how microtubule asters translocate in cells and position such structures as sperm asters and mitotic spindles. Using micromanipulation, advanced imaging, reverse genetics, as well as biochemical approaches in dividing echinoderm and ascidian eggs, we are analyzing how the fertilizing sperm aster migrates in the egg after fertilization and subsequently captures the female pronuceus. We actively collaborate with other scientists around the world, including mathematical modelers, advanced imaging specialists, and experts at using eggs of marine animals. We share a laboratory with other scientists working on cell motility and cell division at the Marine Biological Laboratory during the summer months.
Boston College: Morrissey College of Art
Web Page: https://www.bc.edu/bc-web/schools/mcas/departments/biology/people/faculty-directory/david-burgess.html