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Profile Publications(61)
ECB-PERS-4087

Publications By L Courtney Smith

Results 1 - 50 of 61 results

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The echinoid complement system inferred from genome sequence searches., Smith LC, Crow RS, Franchi N, Schrankel CS., Dev Comp Immunol. March 1, 2023; 140 104584.


The complex set of internal repeats in SpTransformer protein sequences result in multiple but limited alternative alignments., Barela Hudgell MA, Smith LC., Front Immunol. October 18, 2022; 13 1000177.


Coelomocyte populations in the sea urchin, Strongylocentrotus purpuratus, undergo dynamic changes in response to immune challenge., Barela Hudgell MA, Grayfer L, Smith LC., Front Immunol. July 14, 2022; 13 940852.            


Lipofection mediated transfection fails for sea urchin coelomocytes., Barela Hudgell MA, Smith LC., PLoS One. May 5, 2022; 17 (5): e0267911.        


A flow cytometry based approach to identify distinct coelomocyte subsets of the purple sea urchin, Strongylocentrotus purpuratus., Barela Hudgell MA, Grayfer L, Smith LC., Dev Comp Immunol. May 1, 2022; 130 104352.


Sequence Diversity, Locus Structure, and Evolutionary History of the SpTransformer Genes in the Sea Urchin Genome., Barela Hudgell MA, Smith LC., Front Immunol. March 18, 2021; 12 744783.                  


The Axial Organ and the Pharynx Are Sites of Hematopoiesis in the Sea Urchin., Golconda P, Buckley KM, Reynolds CR, Romanello JP, Smith LC., Front Immunol. April 25, 2019; 10 870.              


Individual Sea Urchin Coelomocytes Undergo Somatic Immune Gene Diversification., Oren M, Rosental B, Hawley TS, Kim GY, Agronin J, Reynolds CR, Grayfer L, Smith LC., Front Immunol. April 25, 2019; 10 1298.                


Methods for collection, handling, and analysis of sea urchin coelomocytes., Smith LC, Hawley TS, Henson JH, Majeske AJ, Oren M, Rosental B., Methods Cell Biol. January 1, 2019; 150 357-389.


SpTransformer proteins from the purple sea urchin opsonize bacteria, augment phagocytosis, and retard bacterial growth., Chou HY, Lun CM, Smith LC., PLoS One. May 8, 2018; 13 (5): e0196890.                  


Multitasking Immune Sp185/333 Protein, rSpTransformer-E1, and Its Recombinant Fragments Undergo Secondary Structural Transformation upon Binding Targets., Lun CM, Bishop BM, Smith LC., J Immunol. April 1, 2017; 198 (7): 2957-2966.


The Recombinant Sea Urchin Immune Effector Protein, rSpTransformer-E1, Binds to Phosphatidic Acid and Deforms Membranes., Lun CM, Samuel RL, Gillmor SD, Boyd A, Smith LC., Front Immunol. March 13, 2017; 8 481.                  


The SpTransformer Gene Family (Formerly Sp185/333) in the Purple Sea Urchin and the Functional Diversity of the Anti-Pathogen rSpTransformer-E1 Protein., Smith LC, Lun CM., Front Immunol. March 13, 2017; 8 725.                          


Short tandem repeats, segmental duplications, gene deletion, and genomic instability in a rapidly diversified immune gene family., Oren M, Barela Hudgell MA, D'Allura B, Agronin J, Gross A, Podini D, Smith LC., BMC Genomics. November 9, 2016; 17 (1): 900.            


A recombinant Sp185/333 protein from the purple sea urchin has multitasking binding activities towards certain microbes and PAMPs., Lun CM, Schrankel CS, Chou HY, Sacchi S, Smith LC., Immunobiology. August 1, 2016; 221 (8): 889-903.


Extraordinary Diversity of Immune Response Proteins among Sea Urchins: Nickel-Isolated Sp185/333 Proteins Show Broad Variations in Size and Charge., Sherman LS, Schrankel CS, Brown KJ, Smith LC., PLoS One. September 2, 2015; 10 (9): e0138892.                    


Single sea urchin phagocytes express messages of a single sequence from the diverse Sp185/333 gene family in response to bacterial challenge., Majeske AJ, Oren M, Sacchi S, Smith LC., J Immunol. December 1, 2014; 193 (11): 5678-88.


The Sp185/333 immune response genes and proteins are expressed in cells dispersed within all major organs of the adult purple sea urchin., Majeske AJ, Oleksyk TK, Smith LC., Innate Immun. December 1, 2013; 19 (6): 569-87.


Shotgun proteomics of coelomic fluid from the purple sea urchin, Strongylocentrotus purpuratus., Dheilly NM, Raftos DA, Haynes PA, Smith LC, Nair SV., Dev Comp Immunol. May 1, 2013; 40 (1): 35-50.


Aggregation of sea urchin phagocytes is augmented in vitro by lipopolysaccharide., Majeske AJ, Bayne CJ, Smith LC., PLoS One. April 16, 2013; 8 (4): e61419.                      


Innate immune complexity in the purple sea urchin: diversity of the sp185/333 system., Smith LC., Front Immunol. February 29, 2012; 3 70.                              


Invertebrate immune diversity., Ghosh J, Lun CM, Majeske AJ, Sacchi S, Schrankel CS, Smith LC., Dev Comp Immunol. September 1, 2011; 35 (9): 959-74.


An Sp185/333 gene cluster from the purple sea urchin and putative microsatellite-mediated gene diversification., Miller CA, Buckley KM, Easley RL, Smith LC., BMC Genomics. October 18, 2010; 11 575.                      


SpTie1/2 is expressed in coelomocytes, axial organ and embryos of the sea urchin Strongylocentrotus purpuratus, and is an orthologue of vertebrate Tie1 and Tie2., Stevens ME, Dhillon J, Miller CA, Messier-Solek C, Majeske AJ, Zuelke D, Rast JP, Smith LC., Dev Comp Immunol. August 1, 2010; 34 (8): 884-95.


Two recombinant peptides, SpStrongylocins 1 and 2, from Strongylocentrotus purpuratus, show antimicrobial activity against Gram-positive and Gram-negative bacteria., Li C, Blencke HM, Smith LC, Karp MT, Stensvåg K., Dev Comp Immunol. March 1, 2010; 34 (3): 286-92.


Sp185/333: a novel family of genes and proteins involved in the purple sea urchin immune response., Ghosh J, Buckley KM, Nair SV, Raftos DA, Miller C, Majeske AJ, Hibino T, Rast JP, Roth M, Smith LC., Dev Comp Immunol. March 1, 2010; 34 (3): 235-45.


Diversification of innate immune genes: lessons from the purple sea urchin., Smith LC., Dis Model Mech. January 1, 2010; 3 (5-6): 274-9.


Echinoderm immunity., Smith LC, Ghosh J, Buckley KM, Clow LA, Dheilly NM, Haug T, Henson JH, Li C, Lun CM, Majeske AJ, Matranga V, Nair SV, Rast JP, Raftos DA, Roth M, Sacchi S, Schrankel CS, Stensvåg K., Adv Exp Med Biol. January 1, 2010; 708 260-301.


A method for identifying alternative or cryptic donor splice sites within gene and mRNA sequences. Comparisons among sequences from vertebrates, echinoderms and other groups., Buckley KM, Florea LD, Smith LC., BMC Genomics. July 16, 2009; 10 318.      


Highly variable immune-response proteins (185/333) from the sea urchin, Strongylocentrotus purpuratus: proteomic analysis identifies diversity within and between individuals., Dheilly NM, Nair SV, Smith LC, Raftos DA., J Immunol. February 15, 2009; 182 (4): 2203-12.


Sequence variations in 185/333 messages from the purple sea urchin suggest posttranscriptional modifications to increase immune diversity., Buckley KM, Terwilliger DP, Smith LC., J Immunol. December 15, 2008; 181 (12): 8585-94.


The 185/333 gene family is a rapidly diversifying host-defense gene cluster in the purple sea urchin Strongylocentrotus purpuratus., Buckley KM, Munshaw S, Kepler TB, Smith LC., J Mol Biol. June 13, 2008; 379 (4): 912-28.


Localization and diversity of 185/333 proteins from the purple sea urchin--unexpected protein-size range and protein expression in a new coelomocyte type., Brockton V, Henson JH, Raftos DA, Majeske AJ, Kim YO, Smith LC., J Cell Sci. February 1, 2008; 121 (Pt 3): 339-48.


Extraordinary diversity among members of the large gene family, 185/333, from the purple sea urchin, Strongylocentrotus purpuratus., Buckley KM, Smith LC., BMC Mol Biol. August 15, 2007; 8 68.                


Distinctive expression patterns of 185/333 genes in the purple sea urchin, Strongylocentrotus purpuratus: an unexpectedly diverse family of transcripts in response to LPS, beta-1,3-glucan, and dsRNA., Terwilliger DP, Buckley KM, Brockton V, Ritter NJ, Smith LC., BMC Mol Biol. March 1, 2007; 8 16.    


The immune gene repertoire encoded in the purple sea urchin genome., Hibino T, Loza-Coll M, Messier C, Majeske AJ, Cohen AH, Terwilliger DP, Buckley KM, Brockton V, Nair SV, Berney K, Fugmann SD, Anderson MK, Pancer Z, Cameron RA, Smith LC, Rast JP., Dev Biol. December 1, 2006; 300 (1): 349-65.


The genome of the sea urchin Strongylocentrotus purpuratus., null null, Sodergren E, Weinstock GM, Davidson EH, Cameron RA, Gibbs RA, Angerer RC, Angerer LM, Arnone MI, Burgess DR, Burke RD, Coffman JA, Dean M, Elphick MR, Ettensohn CA, Foltz KR, Hamdoun A, Hynes RO, Klein WH, Marzluff W, McClay DR, Morris RL, Mushegian A, Rast JP, Smith LC, Thorndyke MC, Vacquier VD, Wessel GM, Wray G, Zhang L, Elsik CG, Ermolaeva O, Hlavina W, Hofmann G, Kitts P, Landrum MJ, Mackey AJ, Maglott D, Panopoulou G, Poustka AJ, Pruitt K, Sapojnikov V, Song X, Souvorov A, Solovyev V, Wei Z, Whittaker CA, Worley K, Durbin KJ, Shen Y, Fedrigo O, Garfield D, Haygood R, Primus A, Satija R, Severson T, Gonzalez-Garay ML, Jackson AR, Milosavljevic A, Tong M, Killian CE, Livingston BT, Wilt FH, Adams N, Bellé R, Carbonneau S, Cheung R, Cormier P, Cosson B, Croce J, Fernandez-Guerra A, Genevière AM, Goel M, Kelkar H, Morales J, Mulner-Lorillon O, Robertson AJ, Goldstone JV, Cole B, Epel D, Gold B, Hahn ME, Howard-Ashby M, Scally M, Stegeman JJ, Allgood EL, Cool J, Judkins KM, McCafferty SS, Musante AM, Obar RA, Rawson AP, Rossetti BJ, Gibbons IR, Hoffman MP, Leone A, Istrail S, Materna SC, Samanta MP, Stolc V, Tongprasit W, Tu Q, Bergeron KF, Brandhorst BP, Whittle J, Berney K, Bottjer DJ, Calestani C, Peterson K, Chow E, Yuan QA, Elhaik E, Graur D, Reese JT, Bosdet I, Heesun S, Marra MA, Schein J, Anderson MK, Brockton V, Buckley KM, Cohen AH, Fugmann SD, Hibino T, Loza-Coll M, Majeske AJ, Messier C, Nair SV, Pancer Z, Terwilliger DP, Agca C, Arboleda E, Chen N, Churcher AM, Hallböök F, Humphrey GW, Idris MM, Kiyama T, Liang S, Mellott D, Mu X, Murray G, Olinski RP, Raible F, Rowe M, Taylor JS, Tessmar-Raible K, Wang D, Wilson KH, Yaguchi S, Gaasterland T, Galindo BE, Gunaratne HJ, Juliano C, Kinukawa M, Moy GW, Neill AT, Nomura M, Raisch M, Reade A, Roux MM, Song JL, Su YH, Townley IK, Voronina E, Wong JL, Amore G, Branno M, Brown ER, Cavalieri V, Duboc V, Duloquin L, Flytzanis C, Gache C, Lapraz F, Lepage T, Locascio A, Martinez P, Matassi G, Matranga V, Range R, Rizzo F, Röttinger E, Beane W, Bradham C, Byrum C, Glenn T, Hussain S, Manning G, Miranda E, Thomason R, Walton K, Wikramanayke A, Wu SY, Xu R, Brown CT, Chen L, Gray RF, Lee PY, Nam J, Oliveri P, Smith J, Muzny D, Bell S, Chacko J, Cree A, Curry S, Davis C, Dinh H, Dugan-Rocha S, Fowler J, Gill R, Hamilton C, Hernandez J, Hines S, Hume J, Jackson L, Jolivet A, Kovar C, Lee S, Lewis L, Miner G, Morgan M, Nazareth LV, Okwuonu G, Parker D, Pu LL, Thorn R, Wright R., Science. November 10, 2006; 314 (5801): 941-52.


Genomic insights into the immune system of the sea urchin., Rast JP, Smith LC, Loza-Coll M, Hibino T, Litman GW., Science. November 10, 2006; 314 (5801): 952-6.


Unexpected diversity displayed in cDNAs expressed by the immune cells of the purple sea urchin, Strongylocentrotus purpuratus., Terwilliger DP, Buckley KM, Mehta D, Moorjani PG, Smith LC., Physiol Genomics. July 12, 2006; 26 (2): 134-44.


Macroarray analysis of coelomocyte gene expression in response to LPS in the sea urchin. Identification of unexpected immune diversity in an invertebrate., Nair SV, Del Valle H, Gross PS, Terwilliger DP, Smith LC., Physiol Genomics. June 16, 2005; 22 (1): 33-47.


Constitutive expression and alternative splicing of the exons encoding SCRs in Sp152, the sea urchin homologue of complement factor B. Implications on the evolution of the Bf/C2 gene family., Terwilliger DP, Clow LA, Gross PS, Smith LC., Immunogenetics. October 1, 2004; 56 (7): 531-43.


Two cDNAs from the purple sea urchin, Strongylocentrotus purpuratus, encoding mosaic proteins with domains found in factor H, factor I, and complement components C6 and C7., Multerer KA, Smith LC., Immunogenetics. May 1, 2004; 56 (2): 89-106.


The sea urchin complement homologue, SpC3, functions as an opsonin., Clow LA, Raftos DA, Gross PS, Smith LC., J Exp Biol. May 1, 2004; 207 (Pt 12): 2147-55.


The gene encoding the sea urchin complement protein, SpC3, is expressed in embryos and can be upregulated by bacteria., Shah M, Brown KM, Smith LC., Dev Comp Immunol. January 1, 2003; 27 (6-7): 529-38.


Thioester function is conserved in SpC3, the sea urchin homologue of the complement component C3., Smith LC., Dev Comp Immunol. September 1, 2002; 26 (7): 603-14.


The ancestral complement system in sea urchins., Smith LC, Clow LA, Terwilliger DP., Immunol Rev. April 1, 2001; 180 16-34.


The complement system in sea urchins., Smith LC., Adv Exp Med Biol. January 1, 2001; 484 363-72.


Expression of SpC3, the sea urchin complement component, in response to lipopolysaccharide., Clow LA, Gross PS, Shih CS, Smith LC., Immunogenetics. October 1, 2000; 51 (12): 1021-33.


SpC3, the complement homologue from the purple sea urchin, Strongylocentrotus purpuratus, is expressed in two subpopulations of the phagocytic coelomocytes., Gross PS, Clow LA, Smith LC., Immunogenetics. October 1, 2000; 51 (12): 1034-44.


Complement systems in invertebrates. The ancient alternative and lectin pathways., Smith LC, Azumi K, Nonaka M., Immunopharmacology. May 1, 1999; 42 (1-3): 107-20.

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