Publications By Thierry Lepage

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RAS-independent ERK activation by constitutively active KSR3 in non-chordate metazoa., Chessel A, De Crozé N, Molina MD, Taberner L, Dru P, Martin L, Lepage T., Nat Commun. July 5, 2023; 14 (1): 3970.

Deciphering and modelling the TGF-β signalling interplays specifying the dorsal-ventral axis of the sea urchin embryo., Floc'hlay S, Molina MD, Hernandez C, Haillot E, Thomas-Chollier M, Lepage T, Thieffry D., Development. January 20, 2021; 148 (2):

Maternal factors regulating symmetry breaking and dorsal-ventral axis formation in the sea urchin embryo., Molina MD, Lepage T., Curr Top Dev Biol. January 1, 2020; 140 283-316.

Expression of exogenous mRNAs to study gene function in echinoderm embryos., Molina MD, Gache C, Lepage T., Methods Cell Biol. January 1, 2019; 151 239-282.

MAPK and GSK3/ß-TRCP-mediated degradation of the maternal Ets domain transcriptional repressor Yan/Tel controls the spatial expression of nodal in the sea urchin embryo., Molina MD, Quirin M, Haillot E, De Crozé N, Range R, Rouel M, Jimenez F, Amrouche R, Chessel A, Lepage T., PLoS Genet. September 17, 2018; 14 (9): e1007621.

p38 MAPK as an essential regulator of dorsal-ventral axis specification and skeletogenesis during sea urchin development: a re-evaluation., Molina MD, Quirin M, Haillot E, Jimenez F, Chessel A, Lepage T., Development. June 15, 2017; 144 (12): 2270-2281.

A minimal molecular toolkit for mineral deposition? Biochemistry and proteomics of the test matrix of adult specimens of the sea urchin Paracentrotus lividus., Karakostis K, Zanella-Cléon I, Immel F, Guichard N, Dru P, Lepage T, Plasseraud L, Matranga V, Marin F., J Proteomics. March 16, 2016; 136 133-44.

A deuterostome origin of the Spemann organiser suggested by Nodal and ADMPs functions in Echinoderms., Lapraz F, Haillot E, Lepage T., Nat Commun. October 1, 2015; 6 8434.

The Maternal Maverick/GDF15-like TGF-β Ligand Panda Directs Dorsal-Ventral Axis Formation by Restricting Nodal Expression in the Sea Urchin Embryo., Haillot E, Molina MD, Lapraz F, Lepage T., PLoS Biol. September 9, 2015; 13 (9): e1002247.

Nodal: master and commander of the dorsal-ventral and left-right axes in the sea urchin embryo., Molina MD, de Crozé N, Haillot E, Lepage T., Curr Opin Genet Dev. August 1, 2013; 23 (4): 445-53.

Reciprocal signaling between the ectoderm and a mesendodermal left-right organizer directs left-right determination in the sea urchin embryo., Bessodes N, Haillot E, Duboc V, Röttinger E, Lahaye F, Lepage T., PLoS Genet. January 1, 2012; 8 (12): e1003121.

Maternal Oct1/2 is required for Nodal and Vg1/Univin expression during dorsal-ventral axis specification in the sea urchin embryo., Range R, Lepage T., Dev Biol. September 15, 2011; 357 (2): 440-9.

Wnt6 activates endoderm in the sea urchin gene regulatory network., Croce J, Range R, Wu SY, Miranda E, Lhomond G, Peng JC, Lepage T, McClay DR., Development. August 1, 2011; 138 (15): 3297-306.

Ancestral regulatory circuits governing ectoderm patterning downstream of Nodal and BMP2/4 revealed by gene regulatory network analysis in an echinoderm., Saudemont A, Haillot E, Mekpoh F, Bessodes N, Quirin M, Lapraz F, Duboc V, Röttinger E, Range R, Oisel A, Besnardeau L, Wincker P, Lepage T., PLoS Genet. December 23, 2010; 6 (12): e1001259.

Nodal and BMP2/4 pattern the mesoderm and endoderm during development of the sea urchin embryo., Duboc V, Lapraz F, Saudemont A, Bessodes N, Mekpoh F, Haillot E, Quirin M, Lepage T., Development. January 1, 2010; 137 (2): 223-35.

Patterning of the dorsal-ventral axis in echinoderms: insights into the evolution of the BMP-chordin signaling network., Lapraz F, Besnardeau L, Lepage T., PLoS Biol. November 1, 2009; 7 (11): e1000248.

Lefty acts as an essential modulator of Nodal activity during sea urchin oral-aboral axis formation., Duboc V, Lapraz F, Besnardeau L, Lepage T., Dev Biol. August 1, 2008; 320 (1): 49-59.

A conserved role for the nodal signaling pathway in the establishment of dorso-ventral and left-right axes in deuterostomes., Duboc V, Lepage T., J Exp Zool B Mol Dev Evol. January 15, 2008; 310 (1): 41-53.

FGF signals guide migration of mesenchymal cells, control skeletal morphogenesis [corrected] and regulate gastrulation during sea urchin development., Röttinger E, Saudemont A, Duboc V, Besnardeau L, McClay D, Lepage T., Development. January 1, 2008; 135 (2): 353-65.

Cis-regulatory analysis of nodal and maternal control of dorsal-ventral axis formation by Univin, a TGF-beta related to Vg1., Range R, Lapraz F, Quirin M, Marro S, Besnardeau L, Lepage T., Development. October 1, 2007; 134 (20): 3649-64.

The sea urchin kinome: a first look., Bradham CA, Foltz KR, Beane WS, Arnone MI, Rizzo F, Coffman JA, Mushegian A, Goel M, Morales J, Geneviere AM, Lapraz F, Robertson AJ, Kelkar H, Loza-Coll M, Townley IK, Raisch M, Roux MM, Lepage T, Gache C, McClay DR, Manning G., Dev Biol. December 1, 2006; 300 (1): 180-93.

RTK and TGF-beta signaling pathways genes in the sea urchin genome., Lapraz F, Röttinger E, Duboc V, Range R, Duloquin L, Walton K, Wu SY, Bradham C, Loza MA, Hibino T, Wilson K, Poustka A, McClay D, Angerer L, Gache C, Lepage T., Dev Biol. December 1, 2006; 300 (1): 132-52.

The genome of the sea urchin Strongylocentrotus purpuratus., Sea Urchin Genome Sequencing Consortium, Sodergren E, Weinstock GM, Davidson EH, Cameron RA, Gibbs RA, Angerer RC, Angerer LM, Arnone MI, Burgess DR, Burke RD, Coffman JA, Dean M, Elphick MR, Ettensohn CA, Foltz KR, Hamdoun A, Hynes RO, Klein WH, Marzluff W, McClay DR, Morris RL, Mushegian A, Rast JP, Smith LC, Thorndyke MC, Vacquier VD, Wessel GM, Wray G, Zhang L, Elsik CG, Ermolaeva O, Hlavina W, Hofmann G, Kitts P, Landrum MJ, Mackey AJ, Maglott D, Panopoulou G, Poustka AJ, Pruitt K, Sapojnikov V, Song X, Souvorov A, Solovyev V, Wei Z, Whittaker CA, Worley K, Durbin KJ, Shen Y, Fedrigo O, Garfield D, Haygood R, Primus A, Satija R, Severson T, Gonzalez-Garay ML, Jackson AR, Milosavljevic A, Tong M, Killian CE, Livingston BT, Wilt FH, Adams N, Bellé R, Carbonneau S, Cheung R, Cormier P, Cosson B, Croce J, Fernandez-Guerra A, Genevière AM, Goel M, Kelkar H, Morales J, Mulner-Lorillon O, Robertson AJ, Goldstone JV, Cole B, Epel D, Gold B, Hahn ME, Howard-Ashby M, Scally M, Stegeman JJ, Allgood EL, Cool J, Judkins KM, McCafferty SS, Musante AM, Obar RA, Rawson AP, Rossetti BJ, Gibbons IR, Hoffman MP, Leone A, Istrail S, Materna SC, Samanta MP, Stolc V, Tongprasit W, Tu Q, Bergeron KF, Brandhorst BP, Whittle J, Berney K, Bottjer DJ, Calestani C, Peterson K, Chow E, Yuan QA, Elhaik E, Graur D, Reese JT, Bosdet I, Heesun S, Marra MA, Schein J, Anderson MK, Brockton V, Buckley KM, Cohen AH, Fugmann SD, Hibino T, Loza-Coll M, Majeske AJ, Messier C, Nair SV, Pancer Z, Terwilliger DP, Agca C, Arboleda E, Chen N, Churcher AM, Hallböök F, Humphrey GW, Idris MM, Kiyama T, Liang S, Mellott D, Mu X, Murray G, Olinski RP, Raible F, Rowe M, Taylor JS, Tessmar-Raible K, Wang D, Wilson KH, Yaguchi S, Gaasterland T, Galindo BE, Gunaratne HJ, Juliano C, Kinukawa M, Moy GW, Neill AT, Nomura M, Raisch M, Reade A, Roux MM, Song JL, Su YH, Townley IK, Voronina E, Wong JL, Amore G, Branno M, Brown ER, Cavalieri V, Duboc V, Duloquin L, Flytzanis C, Gache C, Lapraz F, Lepage T, Locascio A, Martinez P, Matassi G, Matranga V, Range R, Rizzo F, Röttinger E, Beane W, Bradham C, Byrum C, Glenn T, Hussain S, Manning G, Miranda E, Thomason R, Walton K, Wikramanayke A, Wu SY, Xu R, Brown CT, Chen L, Gray RF, Lee PY, Nam J, Oliveri P, Smith J, Muzny D, Bell S, Chacko J, Cree A, Curry S, Davis C, Dinh H, Dugan-Rocha S, Fowler J, Gill R, Hamilton C, Hernandez J, Hines S, Hume J, Jackson L, Jolivet A, Kovar C, Lee S, Lewis L, Miner G, Morgan M, Nazareth LV, Okwuonu G, Parker D, Pu LL, Thorn R, Wright R., Science. November 10, 2006; 314 (5801): 941-52.

Nemo-like kinase (NLK) acts downstream of Notch/Delta signalling to downregulate TCF during mesoderm induction in the sea urchin embryo., Röttinger E, Croce J, Lhomond G, Besnardeau L, Gache C, Lepage T., Development. November 1, 2006; 133 (21): 4341-53.

Expression pattern of three putative RNA-binding proteins during early development of the sea urchin Paracentrotus lividus., Röttinger E, Besnardeau L, Lepage T., Gene Expr Patterns. October 1, 2006; 6 (8): 864-72.

Left-right asymmetry in the sea urchin embryo is regulated by nodal signaling on the right side., Duboc V, Röttinger E, Lapraz F, Besnardeau L, Lepage T., Dev Cell. July 1, 2005; 9 (1): 147-58.

A Raf/MEK/ERK signaling pathway is required for development of the sea urchin embryo micromere lineage through phosphorylation of the transcription factor Ets., Röttinger E, Besnardeau L, Lepage T., Development. March 1, 2004; 131 (5): 1075-87.

Nodal and BMP2/4 signaling organizes the oral-aboral axis of the sea urchin embryo., Duboc V, Röttinger E, Besnardeau L, Lepage T., Dev Cell. March 1, 2004; 6 (3): 397-410.

Expression of exogenous mRNAs to study gene function in the sea urchin embryo., Lepage T, Gache C., Methods Cell Biol. January 1, 2004; 74 677-97.

GSK3beta/shaggy mediates patterning along the animal-vegetal axis of the sea urchin embryo., Emily-Fenouil F, Ghiglione C, Lhomond G, Lepage T, Gache C., Development. July 1, 1998; 125 (13): 2489-98.

Structure of the gene encoding the sea urchin blastula protease 10 (BP10), a member of the astacin family of Zn2+-metalloproteases., Lhomond G, Ghiglione C, Lepage T, Gache C., Eur J Biochem. June 15, 1996; 238 (3): 744-51.

Structure of the sea urchin hatching enzyme gene., Ghiglione C, Lhomond G, Lepage T, Gache C., Eur J Biochem. February 1, 1994; 219 (3): 845-54.

Cell-autonomous expression and position-dependent repression by Li+ of two zygotic genes during sea urchin early development., Ghiglione C, Lhomond G, Lepage T, Gache C., EMBO J. January 1, 1993; 12 (1): 87-96.

Spatial expression of the hatching enzyme gene in the sea urchin embryo., Lepage T, Sardet C, Gache C., Dev Biol. March 1, 1992; 150 (1): 23-32.

Spatial and temporal expression pattern during sea urchin embryogenesis of a gene coding for a protease homologous to the human protein BMP-1 and to the product of the Drosophila dorsal-ventral patterning gene tolloid., Lepage T, Ghiglione C, Gache C., Development. January 1, 1992; 114 (1): 147-63.

Early expression of a collagenase-like hatching enzyme gene in the sea urchin embryo., Lepage T, Gache C., EMBO J. September 1, 1990; 9 (9): 3003-12.

Purification and characterization of the sea urchin embryo hatching enzyme., Lepage T, Gache C., J Biol Chem. March 25, 1989; 264 (9): 4787-93.

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