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ECB-ANTIBODY-26396151

Antibody Name: msp130 Ab4

Common Name: mesenchyme-specific cell surface glycoprotein

RRID:
Synonyms: 1223, 130-kDa primary mesenchyme cell-specific glycoprotein, mesenchyme-specific protein 130

Antigens
Gene: msp130

Clone Type: Monoclonal
Source:

Antibody
Clone Number 1223
Purification Affinity Purification
Isotype IgG1
Host Organism mouse
Echinoderm Reactivity S. purpuratus, L. pictus
Non-Echinoderm Reactivity
Description: Function-blocking antibody demonstrated to inhibit spiculogenesis of the sea urchin larval skeleton by reacting with a carbohydrate epitope and preventing calcium deposition by the primary mesenchyme cells in vivo. Created and previously supplied by the laboratory of Dr. William Lennarz (formerly M. D. Anderson Hospital and Tumor Institute, Houston, Texas).
Immunogen
Name Gastrula-Stage Embryonic Cell Suspension
Type other immunogen type
Post Translational Modifications Glycosylation
Source Organism purple sea urchin
Description 1-10^6 cells obtained by filtering glycoprotein-containing cells from dissociated mesenchyme blastula stage (20-21 hpf) embryos.
Sequence
Reported Usage
immunofluorescence
immunoprecipitation
western blot
Publications
???displayAntibody.papersFirst??? A monoclonal antibody inhibits calcium accumulation and skeleton formation in cultured embryonic cells of the sea urchin., Cell 1985  
???displayAntibody.papersRecent??? A method of microinjection: delivering monoclonal antibody 1223 into sea urchin embryos., Mol Cells 1999  
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