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Echinobase

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ECB-ANTIBODY-26395840

Antibody Name: pkd1l2a Ab2

Common Name: polycystin 1 like 2 (gene/pseudogene) A

RRID:
Synonyms: J10/14, REJ, sperm receptor for egg jelly

Antigens
Gene: pkd1l2a

Clone Type: Monoclonal
Source:

Antibody
Clone Number J10/14
Purification
Isotype IgG2a
Host Organism mouse
Echinoderm Reactivity S. purpuratus
Non-Echinoderm Reactivity
Description: Spermatozoa-specific antibody that has been demonstrated to react with a ~210 kDa glycoprotein and disrupt the acrosome reaction. Created and previously supplied by the laboratory of Victor D. Vacquier at the Scripps Institution of Oceanography in San Diego, California.
Immunogen
Name Intact Sea Urchin Sperm
Type other immunogen type
Post Translational Modifications None
Source Organism purple sea urchin
Description Spawned cells suspended in Millipore-filtered seawater.
Sequence
Reported Usage
immunohistochemistry
immunoprecipitation
western blot
enzyme-linked immunosorbent assay
immunofluorescence
Publications
???displayAntibody.papersFirst??? Monoclonal antibody to a membrane glycoprotein inhibits the acrosome reaction and associated Ca2+ and H+ fluxes of sea urchin sperm., Cell 1985  
???displayAntibody.papersRecent??? The sea urchin sperm receptor for egg jelly is a modular protein with extensive homology to the human polycystic kidney disease protein, PKD1., J Cell Biol 1996  
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