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ECB-ART-53338
Mol Reprod Dev 2024 Oct 01;9110:e23774. doi: 10.1002/mrd.23774.
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David Garbers' Contributions to Chemotaxis Signaling in Sperm.

Kaupp UB , Kendall O .


Abstract
This review focuses on the contribution of the late David Garbers to chemotaxis of sperm, in particular from sea urchin. We will describe his discovery of chemotactic peptides and their cognate receptors, his discovery of a sperm-specific, unique Na+/H+ exchanger that represents a chimera between a solute carrier (SLC) and an ion channel. Finally, we will discuss his contributions to the understanding of cAMP signaling in sperm via soluble adenylyl cyclase (sAC) and its control by Ca2+ ions.

PubMed ID: 39445585
Article link: Mol Reprod Dev
Grant support: [+]