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ECB-ART-48709
Cells 2020 Apr 07;94:. doi: 10.3390/cells9040898.
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A Peak of H3T3 Phosphorylation Occurs in Synchrony with Mitosis in Sea Urchin Early Embryos.

Feizbakhsh O , Pontheaux F , Glippa V , Morales J , Ruchaud S , Cormier P , Roch F .


Abstract
The sea urchin embryo provides a valuable system to analyse the molecular mechanisms orchestrating cell cycle progression and mitosis in a developmental context. However, although it is known that the regulation of histone activity by post-translational modification plays an important role during cell division, the dynamics and the impact of these modifications have not been characterised in detail in a developing embryo. Using different immuno-detection techniques, we show that the levels of Histone 3 phosphorylation at Threonine 3 oscillate in synchrony with mitosis in Sphaerechinus granularis early embryos. We present, in addition, the results of a pharmacological study aimed at analysing the role of this key histone post-translational modification during sea urchin early development.

PubMed ID: 32272587
PMC ID: PMC7226724
Article link: Cells


Genes referenced: impact LOC100887844 LOC115919910


Article Images: [+] show captions
References [+] :
Ashtiyani, AtHaspin phosphorylates histone H3 at threonine 3 during mitosis and contributes to embryonic patterning in Arabidopsis. 2011, Pubmed