ECB-ART-47841
Dev Genes Evol
2002 Oct 01;2129:419-31. doi: 10.1007/s00427-002-0261-0.
Show Gene links
Show Anatomy links
Identification and developmental expression of new biomineralization proteins in the sea urchin Strongylocentrotus purpuratus.
???displayArticle.abstract???
The endoskeleton of the sea urchin larva is a network of calcareous rods secreted by primary mesenchyme cells (PMCs). In this study, we identified seven new biomineralization-related proteins through an analysis of a large database of gene products expressed by PMCs. The proteins include three new spicule matrix proteins (SpSM29, SpSM32, and SpC-lectin), two proteins related to the PMC-specific cell surface glycoprotein MSP130 (MSP130-related-1 and -2), and two novel proteins (SpP16 and SpP19). The genes encoding these proteins are expressed specifically by cells of the large micromere-PMC lineage and are activated zygotically beginning at the blastula stage, prior to PMC ingression. Several of the mRNAs show regulated patterns of expression within the PMC syncytium that correlate with the pattern of skeletal rod growth. This work identifies new proteins that may regulate the process of biomineralization in this tractable model system.
???displayArticle.pubmedLink??? 12373587
???displayArticle.link??? Dev Genes Evol
Genes referenced: LOC100887844 LOC115919910 LOC115924597 LOC115925415 msp130 P16