Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Int J Mol Sci 2019 Oct 28;2021:. doi: 10.3390/ijms20215348.
Show Gene links Show Anatomy links

Immunomodulatory Protein from Nectria haematococca Induces Apoptosis in Lung Cancer Cells via the P53 Pathway.

Wang JJ , Wang Y , Hou L , Xin F , Fan B , Lu C , Zhang L , Wang F , Li S .

Our previous research has shown that a fungal immunomodulatory protein from Nectria haematococca (FIP-nha) possesses a wide spectrum of anti-tumor activities, and FIP-nha induced A549 apoptosis by negatively regulating the PI3K/Akt signaling pathway based on comparative quantitative proteomics. This study further confirmed that the anti-lung cancer activity of FIP-nha was significantly stronger than that of the reported LZ-8 and FIP-fve. Subsequently, 1H NMR-based metabolomics was applied to comprehensively investigate the underlying mechanism, and a clear separation of FIP-nha-treated and untreated groups was achieved using pattern recognition analysis. Four potential pathways associated with the anti-tumor effect of FIP-nha on A549 cells were identified, and these were mainly involved in glycolysis, taurine and hypotaurine metabolism, fructose and mannose metabolism, and glycerolipid metabolism. Metabolic pathway analysis demonstrated that FIP-nha could induce A549 cell apoptosis partly by regulating the p53 inhibition pathway, which then disrupted the Warburg effect, as well as through other metabolic pathways. Using RT-PCR analysis, FIP-nha-induced apoptosis was confirmed to occur through upregulation of p53 expression. This work highlights the possible use of FIP-nha as a therapeutic adjuvant for lung cancer treatment.

PubMed ID: 31661772
PMC ID: PMC6862031
Article link: Int J Mol Sci
Grant support: [+]

Species referenced: Echinodermata
Genes referenced: cit eno4 g6pd LOC100888004 LOC105440390 LOC115919910 LOC115925203 LOC373385 LOC574921 LOC575780 LOC577219 LOC579256 LOC579470 LOC582192 LOC586734 LOC586799 LOC587800 LOC588766 LOC588990 LOC590297 LOC590938 LOC756927 LOC763027 LOC764863 pik3ca pklr pus1 thrb

Article Images: [+] show captions
References [+] :
An, Changes of metabolic profiles in urine after oral administration of quercetin in rats. 2010, Pubmed