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ECB-ART-47254
Front Oncol 2019 May 22;9:406. doi: 10.3389/fonc.2019.00406.
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In vitro and in vivo Induction of p53-Dependent Apoptosis by Extract of Euryale ferox Salisb in A549 Human Caucasian Lung Carcinoma Cancer Cells Is Mediated Through Akt Signaling Pathway.

Nam GH , Jo KJ , Park YS , Kawk HW , Kim SY , Kim YM .


Abstract
Lung cancer is one of the leading causes of death, and mortality rates have steadily been increasing. Recently, several studies were conducted to develop novel, physiologically active compounds from medicinal plant extracts. Several plant-derived extracts and molecules regulate and inhibit signaling molecules associated with the growth and proliferation of cancer cells. Euryale ferox salisb is a medicinal plant that is effective against different types of cancers. In this study, we investigated the apoptotic effects of E. ferox salisb extract (ESE) in A549 lung cancer cells, exerted by the inhibition of the Akt protein and activation of the p53 protein. Our results show that ESE induces apoptosis via the regulation of mitochondrial outer membrane potential and generation of reactive oxygen species (ROS). We demonstrate that apoptosis is induced in a p53-dependent manner when cells are treated with pifithrin-α (a p53 inhibitor) and LY294002 (an Akt inhibitor). The apoptotic effects from ESE were observed in vivo in Balb/c-nu mice bearing A549 xenografts. Altogether, these results suggest that E. ferox salisb extracts exert anti-cancer effects in a p53-dependent manner.

PubMed ID: 31192119
PMC ID: PMC6540844
Article link: Front Oncol


Species referenced: Echinodermata
Genes referenced: bax ehfl LOC100893907 LOC105441782 LOC115919910 LOC582192 LOC583082 LOC590297 ros1


Article Images: [+] show captions
References [+] :
Adams, The Bcl-2 protein family: arbiters of cell survival. 1998, Pubmed