Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Environ Sci Pollut Res Int
2018 Nov 01;2532:32196-32209. doi: 10.1007/s11356-018-3185-6.
Show Gene links
Show Anatomy links
The impact of propranolol, 17α-ethinylestradiol, and gemfibrozil on early life stages of marine organisms: effects and risk assessment.
Capolupo M
,
Díaz-Garduño B
,
Martín-Díaz ML
.
???displayArticle.abstract???
Pharmaceuticals are ubiquitously detected in the marine environment at the ng-μg/L range. Given their biological activity, these compounds are known to induce detrimental effects on biota at relatively low exposure levels; however, whether they affect early life stages of marine species is still unclear. In this study, a set of bioassays was performed to assess the effects of propranolol (PROP), 17-α ethinylestradiol (EE2), and gemfibrozil (GEM) on gamete fertilization and embryonic development of mussels (Mytilus galloprovincialis) and sea urchins (Paracentrotus lividus), and on the survival of seabream (Sparus aurata) larvae. Treatments of PROP (500, 5000, 50,000 ng/L), EE2 (5, 50, 500 ng/L), and GEM (50, 500, 5000 ng/L) were selected to encompass levels comparable or superior to environmental concentrations. Obtained data were tested for dose-response curve fitting and the lowest EC10/LC10 used to calculate risk quotients (RQs) based on the MEC/PNEC. No alteration was induced by PROP on the mussel gamete fertilization, while inhibitory effects were observed at environmental levels of EE2 (500 ng/L) and GEM (5000 ng/L). Fertilization was significantly reduced in sea urchin at all PROP and EE2 dosages. The 48-h exposure to all pharmaceuticals induced the onset of morphological abnormalities in either mussel or sea urchin embryos. Alterations were generally observed at environmentally relevant dosages, except for PROP in mussels, in which alterations occurred only at 50,000 ng/L. A decreased survival of seabream larvae was recorded after 96-h exposure to PROP (all treatments), EE2 (50-500 ng/L), and GEM (500 ng/L). A median RQ > 1 was obtained for all pharmaceuticals, assigning a high risk to their occurrence in marine environments. Overall, results showed that current levels of contamination by pharmaceuticals can impact early stages of marine species, which represent critical junctures in the resilience of coastal ecosystems.
Aguirre-Martínez,
Are standard tests sensitive enough to evaluate effects of human pharmaceuticals in aquatic biota? Facing changes in research approaches when performing risk assessment of drugs.
2015, Pubmed,
Echinobase
Aguirre-Martínez,
Are standard tests sensitive enough to evaluate effects of human pharmaceuticals in aquatic biota? Facing changes in research approaches when performing risk assessment of drugs.
2015,
Pubmed
,
Echinobase
Arnott,
The influence of lipophilicity in drug discovery and design.
2012,
Pubmed
Au,
Effects of cadmium and phenol on motility and ultrastructure of sea urchin and mussel spermatozoa.
2000,
Pubmed
,
Echinobase
Balbi,
Impact of bisphenol A (BPA) on early embryo development in the marine mussel Mytilus galloprovincialis: Effects on gene transcription.
2016,
Pubmed
Balbi,
Diclofenac affects early embryo development in the marine bivalve Mytilus galloprovincialis.
2018,
Pubmed
Bayen,
Occurrence and distribution of pharmaceutically active and endocrine disrupting compounds in Singapore's marine environment: influence of hydrodynamics and physical-chemical properties.
2013,
Pubmed
Beck,
Liquid chromatography-tandem mass spectrometry analysis of estrogenic compounds in coastal surface water of the Baltic Sea.
2005,
Pubmed
Belanger,
Saltatory ontogeny of fishes and sensitive early life stages for ecotoxicology tests.
2010,
Pubmed
Biel-Maeso,
Occurrence, distribution and environmental risk of pharmaceutically active compounds (PhACs) in coastal and ocean waters from the Gulf of Cadiz (SW Spain).
2018,
Pubmed
Braunbeck,
The fish embryo test (FET): origin, applications, and future.
2015,
Pubmed
Caldwell,
Predicted-no-effect concentrations for the steroid estrogens estrone, 17β-estradiol, estriol, and 17α-ethinylestradiol.
2012,
Pubmed
Cantwell,
Spatial patterns of pharmaceuticals and wastewater tracers in the Hudson River Estuary.
2018,
Pubmed
Comeau,
The occurrence of acidic drugs and caffeine in sewage effluents and receiving waters from three coastal watersheds in Atlantic Canada.
2008,
Pubmed
Cunha,
Using early life stages of marine animals to screen the toxicity of priority hazardous and noxious substances.
2017,
Pubmed
,
Echinobase
Daughton,
Pharmaceuticals and the Environment (PiE): Evolution and impact of the published literature revealed by bibliometric analysis.
2016,
Pubmed
DeCourten,
Combined effects of increased temperature and endocrine disrupting pollutants on sex determination, survival, and development across generations.
2017,
Pubmed
Delashoub,
Comparison of the Effects of Clofibrate and Silafibrate on Sperm Parameters Quality and Sex Hormones in Male Rats.
2018,
Pubmed
Denny,
Comparison of relative binding affinities of endocrine active compounds to fathead minnow and rainbow trout estrogen receptors.
2005,
Pubmed
Díaz-Garduño,
Are combined AOPs effective for toxicity reduction in receiving marine environment? Suitability of battery of bioassays for wastewater treatment plant (WWTP) effluent as an ecotoxicological assessment.
2016,
Pubmed
,
Echinobase
Fabbri,
Adaptation of the bivalve embryotoxicity assay for the high throughput screening of emerging contaminants in Mytilus galloprovincialis.
2014,
Pubmed
Fabbri,
Human pharmaceuticals in the marine environment: Focus on exposure and biological effects in animal species.
2016,
Pubmed
Fernández,
Combined toxicity of dissolved mercury with copper, lead and cadmium on embryogenesis and early larval growth of the Paracentrotus lividus sea-urchin.
2001,
Pubmed
,
Echinobase
Franzellitti,
The β-blocker propranolol affects cAMP-dependent signaling and induces the stress response in Mediterranean mussels, Mytilus galloprovincialis.
2011,
Pubmed
Franzellitti,
Investigating appearance and regulation of the MXR phenotype in early embryo stages of the Mediterranean mussel (Mytilus galloprovincialis).
2017,
Pubmed
Fruchart,
Mode of action of fibrates in the regulation of triglyceride and HDL-cholesterol metabolism.
2006,
Pubmed
Gárriz,
Effects of estradiol and ethinylestradiol on sperm quality, fertilization, and embryo-larval survival of pejerrey fish (Odontesthes bonariensis).
2015,
Pubmed
Hashimoto,
Effects of ethinylestradiol on medaka (Oryzias latipes) as measured by sperm motility and fertilization success.
2009,
Pubmed
Hernando,
LC-MS analysis and environmental risk of lipid regulators.
2007,
Pubmed
Ibáñez,
UHPLC-QTOF MS screening of pharmaceuticals and their metabolites in treated wastewater samples from Athens.
2017,
Pubmed
Jeffries,
Alternative methods for toxicity assessments in fish: comparison of the fish embryo toxicity and the larval growth and survival tests in zebrafish and fathead minnows.
2014,
Pubmed
Kidd,
Collapse of a fish population after exposure to a synthetic estrogen.
2007,
Pubmed
Kim,
Human and veterinary pharmaceuticals in the marine environment including fish farms in Korea.
2017,
Pubmed
Klosterhaus,
Method validation and reconnaissance of pharmaceuticals, personal care products, and alkylphenols in surface waters, sediments, and mussels in an urban estuary.
2013,
Pubmed
Kuhl,
Pharmacology of estrogens and progestogens: influence of different routes of administration.
2005,
Pubmed
Lammer,
Is the fish embryo toxicity test (FET) with the zebrafish (Danio rerio) a potential alternative for the fish acute toxicity test?
2009,
Pubmed
Laurenson,
Ethinyl estradiol and other human pharmaceutical estrogens in the aquatic environment: a review of recent risk assessment data.
2014,
Pubmed
Lenzi,
Lipids of the sperm plasma membrane: from polyunsaturated fatty acids considered as markers of sperm function to possible scavenger therapy.
1996,
Pubmed
Loureiro,
Toxicity of three binary mixtures to Daphnia magna: comparing chemical modes of action and deviations from conceptual models.
2010,
Pubmed
Manzo,
Sea urchin embryotoxicity test: proposal for a simplified bioassay.
2004,
Pubmed
,
Echinobase
Maszkowska,
Beta-blockers in the environment: part I. Mobility and hydrolysis study.
2014,
Pubmed
McEneff,
A year-long study of the spatial occurrence and relative distribution of pharmaceutical residues in sewage effluent, receiving marine waters and marine bivalves.
2014,
Pubmed
Migliore,
Low Doses of Tetracycline Trigger the E. coli Growth: A Case of Hormetic Response.
2013,
Pubmed
Miller,
Cardiac responses to hypercapnia in larval zebrafish (Danio rerio): the links between CO2 chemoreception, catecholamines and carbonic anhydrase.
2014,
Pubmed
Mills,
Review of evidence: are endocrine-disrupting chemicals in the aquatic environment impacting fish populations?
2005,
Pubmed
Parrott,
Life-cycle exposure of fathead minnows (Pimephales promelas) to an ethinylestradiol concentration below 1 ng/L reduces egg fertilization success and demasculinizes males.
2005,
Pubmed
Pintado-Herrera,
Environmentally friendly analysis of emerging contaminants by pressurized hot water extraction-stir bar sorptive extraction-derivatization and gas chromatography-mass spectrometry.
2013,
Pubmed
Pojana,
Natural and synthetic endocrine disrupting compounds (EDCs) in water, sediment and biota of a coastal lagoon.
2007,
Pubmed
Publicover,
[Ca2+]i signalling in sperm--making the most of what you've got.
2007,
Pubmed
Ribeiro,
Toxicity screening of diclofenac, propranolol, sertraline and simvastatin using Danio rerio and Paracentrotus lividus embryo bioassays.
2015,
Pubmed
,
Echinobase
Ritz,
Toward a unified approach to dose-response modeling in ecotoxicology.
2010,
Pubmed
Roberts,
The occurrence of selected pharmaceuticals in wastewater effluent and surface waters of the lower Tyne catchment.
2006,
Pubmed
Rocha,
Pollution by endocrine disruptors in a southwest European temperate coastal lagoon (Ria de Aveiro, Portugal).
2016,
Pubmed
Roepke,
Estradiol and endocrine disrupting compounds adversely affect development of sea urchin embryos at environmentally relevant concentrations.
2005,
Pubmed
,
Echinobase
Runnalls,
Preliminary studies into the effects of the human pharmaceutical Clofibric acid on sperm parameters in adult Fathead minnow.
2007,
Pubmed
Salamanca,
Improved sea-urchin embryo bioassay for in situ evaluation of dredged material.
2009,
Pubmed
,
Echinobase
Salesa,
Effect of the lipid regulator Gemfibrozil in the Cladocera Daphnia magna at different temperatures.
2017,
Pubmed
Santos,
Gonadal transcriptome responses and physiological consequences of exposure to oestrogen in breeding zebrafish (Danio rerio).
2007,
Pubmed
Santos,
Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment.
2010,
Pubmed
Saranjampour,
Salinity impacts on water solubility and n-octanol/water partition coefficients of selected pesticides and oil constituents.
2017,
Pubmed
Sauvé,
A review of what is an emerging contaminant.
2014,
Pubmed
Schulster,
The role of estradiol in male reproductive function.
2016,
Pubmed
Sluder,
Using sea urchin gametes and zygotes to investigate centrosome duplication.
2016,
Pubmed
,
Echinobase
Spongberg,
Reconnaissance of selected PPCP compounds in Costa Rican surface waters.
2011,
Pubmed
Steele,
In vivo and in vitro assessment of cardiac beta-adrenergic receptors in larval zebrafish (Danio rerio).
2011,
Pubmed
Steenen,
Propranolol for the treatment of anxiety disorders: Systematic review and meta-analysis.
2016,
Pubmed
Steinkey,
Effects of gemfibrozil on the growth, reproduction, and energy stores of Daphnia magna in the presence of varying food concentrations.
2018,
Pubmed
Tasdighi,
Development and In-vitro Evaluation of a Contraceptive Vagino-Adhesive Propranolol Hydrochloride Gel.
2012,
Pubmed
Teles,
Evaluation of gemfibrozil effects on a marine fish (Sparus aurata) combining gene expression with conventional endocrine and biochemical endpoints.
2016,
Pubmed
Thomas,
The occurrence of selected human pharmaceutical compounds in UK estuaries.
2004,
Pubmed
Thorpe,
Relative potencies and combination effects of steroidal estrogens in fish.
2003,
Pubmed
Vandenberg,
Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses.
2012,
Pubmed
White,
Complementary effects of propranolol and nonoxynol-9 upon human sperm motility.
1995,
Pubmed
Wilkinson,
Occurrence, fate and transformation of emerging contaminants in water: An overarching review of the field.
2017,
Pubmed
Wille,
Rapid quantification of pharmaceuticals and pesticides in passive samplers using ultra high performance liquid chromatography coupled to high resolution mass spectrometry.
2011,
Pubmed
Yang,
Occurrence and phase distribution of selected pharmaceuticals in the Yangtze Estuary and its coastal zone.
2011,
Pubmed
Yúfera,
Transcriptomic characterization of the larval stage in gilthead seabream (Sparus aurata) by 454 pyrosequencing.
2012,
Pubmed
Zhou,
Behaviour of selected endocrine-disrupting chemicals in three sewage treatment plants of Beijing, China.
2010,
Pubmed
