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Nutrients
2018 Jan 09;101:. doi: 10.3390/nu10010054.
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Higher Protein Intake Is Not Associated with Decreased Kidney Function in Pre-Diabetic Older Adults Following a One-Year Intervention-A Preview Sub-Study.
Møller G
,
Rikardt Andersen J
,
Ritz C
,
P Silvestre M
,
Navas-Carretero S
,
Jalo E
,
Christensen P
,
Simpson E
,
Taylor M
,
Martinez JA
,
Macdonald I
,
Swindell N
,
Mackintosh KA
,
Stratton G
,
Fogelholm M
,
Larsen TM
,
Poppitt SD
,
Dragsted LO
,
Raben A
.
Abstract
Concerns about detrimental renal effects of a high-protein intake have been raised due to an induced glomerular hyperfiltration, since this may accelerate the progression of kidney disease. The aim of this sub-study was to assess the effect of a higher intake of protein on kidney function in pre-diabetic men and women, aged 55 years and older. Analyses were based on baseline and one-year data in a sub-group of 310 participants included in the PREVIEW project (PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World). Protein intake was estimated from four-day dietary records and 24-hour urinary urea excretion. We used linear regression to assess the association between protein intake after one year of intervention and kidney function markers: creatinine clearance, estimated glomerular filtration rate (eGFR), urinary albumin/creatinine ratio (ACR), urinary urea/creatinine ratio (UCR), serum creatinine, and serum urea before and after adjustments for potential confounders. A higher protein intake was associated with a significant increase in UCR (p = 0.03) and serum urea (p = 0.05) after one year. There were no associations between increased protein intake and creatinine clearance, eGFR, ACR, or serum creatinine. We found no indication of impaired kidney function after one year with a higher protein intake in pre-diabetic older adults.
American Diabetes Association,
4. Lifestyle Management.
2017, Pubmed
American Diabetes Association,
4. Lifestyle Management.
2017,
Pubmed
Austin,
Trends in carbohydrate, fat, and protein intakes and association with energy intake in normal-weight, overweight, and obese individuals: 1971-2006.
2011,
Pubmed
Bankir,
Direct and indirect cost of urea excretion.
1996,
Pubmed
Berryman,
Diets higher in animal and plant protein are associated with lower adiposity and do not impair kidney function in US adults.
2016,
Pubmed
Bingham,
Urine nitrogen as a biomarker for the validation of dietary protein intake.
2003,
Pubmed
Brenner,
Dietary protein intake and the progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease.
1982,
Pubmed
Brinkworth,
Renal function following long-term weight loss in individuals with abdominal obesity on a very-low-carbohydrate diet vs high-carbohydrate diet.
2010,
Pubmed
Diabetes Prevention Program (DPP) Research Group,
The Diabetes Prevention Program (DPP): description of lifestyle intervention.
2002,
Pubmed
Fogelholm,
PREVIEW: Prevention of Diabetes through Lifestyle Intervention and Population Studies in Europe and around the World. Design, Methods, and Baseline Participant Description of an Adult Cohort Enrolled into a Three-Year Randomised Clinical Trial.
2017,
Pubmed
Frank,
Effect of short-term high-protein compared with normal-protein diets on renal hemodynamics and associated variables in healthy young men.
2009,
Pubmed
Friedman,
Comparative effects of low-carbohydrate high-protein versus low-fat diets on the kidney.
2012,
Pubmed
Goldstein,
Beneficial health effects of modest weight loss.
1992,
Pubmed
Halbesma,
High protein intake associates with cardiovascular events but not with loss of renal function.
2009,
Pubmed
Jesudason,
Interpreting different measures of glomerular filtration rate in obesity and weight loss: pitfalls for the clinician.
2012,
Pubmed
Jesudason,
Weight-loss diets in people with type 2 diabetes and renal disease: a randomized controlled trial of the effect of different dietary protein amounts.
2013,
Pubmed
Juraschek,
Effect of a high-protein diet on kidney function in healthy adults: results from the OmniHeart trial.
2013,
Pubmed
King,
Dietary protein and renal function.
1993,
Pubmed
Knight,
The impact of protein intake on renal function decline in women with normal renal function or mild renal insufficiency.
2003,
Pubmed
Krebs,
The Diabetes Excess Weight Loss (DEWL) Trial: a randomised controlled trial of high-protein versus high-carbohydrate diets over 2 years in type 2 diabetes.
2012,
Pubmed
Larsen,
Diets with high or low protein content and glycemic index for weight-loss maintenance.
2010,
Pubmed
Larsen,
The effect of high-protein, low-carbohydrate diets in the treatment of type 2 diabetes: a 12 month randomised controlled trial.
2011,
Pubmed
Leidy,
The role of protein in weight loss and maintenance.
2015,
Pubmed
Levey,
A new equation to estimate glomerular filtration rate.
2009,
Pubmed
Li,
Protein-enriched meal replacements do not adversely affect liver, kidney or bone density: an outpatient randomized controlled trial.
2010,
Pubmed
Lindström,
The Finnish Diabetes Prevention Study (DPS): Lifestyle intervention and 3-year results on diet and physical activity.
2003,
Pubmed
Marckmann,
High-protein diets and renal health.
2015,
Pubmed
Nuttall,
The metabolic response to a high-protein, low-carbohydrate diet in men with type 2 diabetes mellitus.
2006,
Pubmed
Pan,
Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study.
1997,
Pubmed
Pedersen,
Health effects of protein intake in healthy adults: a systematic literature review.
2013,
Pubmed
Plantinga,
Prevalence of chronic kidney disease in US adults with undiagnosed diabetes or prediabetes.
2010,
Pubmed
Schwingshackl,
Comparison of high vs. normal/low protein diets on renal function in subjects without chronic kidney disease: a systematic review and meta-analysis.
2014,
Pubmed
Skov,
Randomized trial on protein vs carbohydrate in ad libitum fat reduced diet for the treatment of obesity.
1999,
Pubmed
Skov,
Changes in renal function during weight loss induced by high vs low-protein low-fat diets in overweight subjects.
1999,
Pubmed
Tay,
Long-Term Effects of a Very Low Carbohydrate Compared With a High Carbohydrate Diet on Renal Function in Individuals With Type 2 Diabetes: A Randomized Trial.
2015,
Pubmed
Troiano,
Physical activity in the United States measured by accelerometer.
2008,
Pubmed
Trumbo,
Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein and amino acids.
2002,
Pubmed
Westerterp-Plantenga,
High protein intake sustains weight maintenance after body weight loss in humans.
2004,
Pubmed
da Rocha Fernandes,
IDF Diabetes Atlas estimates of 2014 global health expenditures on diabetes.
2016,
Pubmed
