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Nat Commun 2017 Nov 27;81:1799. doi: 10.1038/s41467-017-01961-y.
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Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes.

Burguera D , Marquez Y , Racioppi C , Permanyer J , Torres-Méndez A , Esposito R , Albuixech-Crespo B , Fanlo L , D'Agostino Y , Gohr A , Navas-Perez E , Riesgo A , Cuomo C , Benvenuto G , Christiaen LA , Martí E , D'Aniello S , Spagnuolo A , Ristoratore F , Arnone MI , Garcia-Fernàndez J , Irimia M .

Epithelial-mesenchymal interactions are crucial for the development of numerous animal structures. Thus, unraveling how molecular tools are recruited in different lineages to control interplays between these tissues is key to understanding morphogenetic evolution. Here, we study Esrp genes, which regulate extensive splicing programs and are essential for mammalian organogenesis. We find that Esrp homologs have been independently recruited for the development of multiple structures across deuterostomes. Although Esrp is involved in a wide variety of ontogenetic processes, our results suggest ancient roles in non-neural ectoderm and regulating specific mesenchymal-to-epithelial transitions in deuterostome ancestors. However, consistent with the extensive rewiring of Esrp-dependent splicing programs between phyla, most developmental defects observed in vertebrate mutants are related to other types of morphogenetic processes. This is likely connected to the origin of an event in Fgfr, which was recruited as an Esrp target in stem chordates and subsequently co-opted into the development of many novel traits in vertebrates.

PubMed ID: 29180615
PMC ID: PMC5703972
Article link: Nat Commun

Species referenced: Echinodermata
Genes referenced: fgfr3 gcml hes hes1 hnf6 impact LOC100887844 LOC100893907 LOC105444881 LOC115919910 LOC115924199 LOC588026 LOC594566 LOC753325 mmut onecut2 pole ptch1 srpl
Morpholinos: LOC588026 MO1 LOC588026 MO2

Article Images: [+] show captions
References [+] :
Abitua, Identification of a rudimentary neural crest in a non-vertebrate chordate. 2012, Pubmed