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Mech Dev 2016 Nov 01;142:10-21. doi: 10.1016/j.mod.2016.08.003.
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Regeneration in bipinnaria larvae of the bat star Patiria miniata induces rapid and broad new gene expression.

Oulhen N , Heyland A , Carrier TJ , Zazueta-Novoa V , Fresques T , Laird J , Onorato TM , Janies D , Wessel G .

BACKGROUND: Some metazoa have the capacity to regenerate lost body parts. This phenomenon in adults has been classically described in echinoderms, especially in sea stars (Asteroidea). Sea star bipinnaria larvae can also rapidly and effectively regenerate a complete larva after surgical bisection. Understanding the capacity to reverse cell fates in the larva is important from both a developmental and biomedical perspective; yet, the mechanisms underlying regeneration in echinoderms are poorly understood. RESULTS: Here, we describe the process of bipinnaria regeneration after bisection in the bat star Patiria miniata. We tested transcriptional, translational, and cell proliferation activity after bisection in anterior and posterior bipinnaria halves as well as expression of SRAP, reported as a sea star regeneration associated protease (Vickery et al., 2001b). Moreover, we found several genes whose transcripts increased in abundance following bisection, including: Vasa, dysferlin, vitellogenin 1 and vitellogenin 2. CONCLUSION: These results show a transformation following bisection, especially in the anterior halves, of cell fate reassignment in all three germ layers, with clear and predictable changes. These results define molecular events that accompany the cell fate changes coincident to the regenerative response in echinoderm larvae.

PubMed ID: 27555501
PMC ID: PMC5154901
Article link: Mech Dev
Grant support: [+]

Genes referenced: ddx4 LOC100887844 LOC105437658 LOC115919910 LOC752081 LOC756768 myp otof

References [+] :
Alié, Somatic stem cells express Piwi and Vasa genes in an adult ctenophore: ancient association of "germline genes" with stemness. 2011, Pubmed