Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Echinobase
ECB-ART-44693
Mediators Inflamm 2016 Jan 01;2016:2457532. doi: 10.1155/2016/2457532.
Show Gene links Show Anatomy links

Walker 256 Tumor Growth Suppression by Crotoxin Involves Formyl Peptide Receptors and Lipoxin A₄.

Brigatte P , Faiad OJ , Ferreira Nocelli RC , Landgraf RG , Palma MS , Cury Y , Curi R , Sampaio SC .


Abstract
We investigated the effects of Crotoxin (CTX), the main toxin of South American rattlesnake (Crotalus durissus terrificus) venom, on Walker 256 tumor growth, the pain symptoms associated (hyperalgesia and allodynia), and participation of endogenous lipoxin A4. Treatment with CTX (s.c.), daily, for 5 days reduced tumor growth at the 5th day after injection of Walker 256 carcinoma cells into the plantar surface of adult rat hind paw. This observation was associated with inhibition of new blood vessel formation and decrease in blood vessel diameter. The treatment with CTX raised plasma concentrations of lipoxin A4 and its natural analogue 15-epi-LXA4, an effect mediated by formyl peptide receptors (FPRs). In fact, the treatment with Boc-2, an inhibitor of FPRs, abolished the increase in plasma levels of these mediators triggered by CTX. The blockage of these receptors also abolished the inhibitory action of CTX on tumor growth and blood vessel formation and the decrease in blood vessel diameter. Together, the results herein presented demonstrate that CTX increases plasma concentrations of lipoxin A4 and 15-epi-LXA4, which might inhibit both tumor growth and formation of new vessels via FPRs.

PubMed ID: 27190493
PMC ID: PMC4844889
Article link: Mediators Inflamm


Genes referenced: LOC100890195 LOC115919910


Article Images: [+] show captions
References [+] :
Bhaumik, Activated macrophages migrate to the subcutaneous tumor site via the peritoneum: a novel route of cell trafficking. 2001, Pubmed