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PLoS One 2016 Jan 01;112:e0149734. doi: 10.1371/journal.pone.0149734.
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Toxic Diatom Aldehydes Affect Defence Gene Networks in Sea Urchins.

Varrella S , Romano G , Costantini S , Ruocco N , Ianora A , Bentley MG , Costantini M .

Marine organisms possess a series of cellular strategies to counteract the negative effects of toxic compounds, including the massive reorganization of gene expression networks. Here we report the modulated dose-dependent response of activated genes by diatom polyunsaturated aldehydes (PUAs) in the sea urchin Paracentrotus lividus. PUAs are secondary metabolites deriving from the oxidation of fatty acids, inducing deleterious effects on the reproduction and development of planktonic and benthic organisms that feed on these unicellular algae and with anti-cancer activity. Our previous results showed that PUAs target several genes, implicated in different functional processes in this sea urchin. Using interactomic Ingenuity Pathway Analysis we now show that the genes targeted by PUAs are correlated with four HUB genes, NF-κB, p53, δ-2-catenin and HIF1A, which have not been previously reported for P. lividus. We propose a working model describing hypothetical pathways potentially involved in toxic aldehyde stress response in sea urchins. This represents the first report on gene networks affected by PUAs, opening new perspectives in understanding the cellular mechanisms underlying the response of benthic organisms to diatom exposure.

PubMed ID: 26914213
PMC ID: PMC4767821
Article link: PLoS One

Species referenced: Echinodermata
Genes referenced: irak1bp1 LOC100887844 LOC100893907 LOC577801 LOC594353

Article Images: [+] show captions
References [+] :
Ben-Tabou de-Leon, Gene regulatory control in the sea urchin aboral ectoderm: spatial initiation, signaling inputs, and cell fate lockdown. 2013, Pubmed, Echinobase