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ECB-ART-43841
Nat Commun 2015 Feb 18;6:6243. doi: 10.1038/ncomms7243.
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A cnidarian homologue of an insect gustatory receptor functions in developmental body patterning.

Saina M , Busengdal H , Sinigaglia C , Petrone L , Oliveri P , Rentzsch F , Benton R .


Abstract
Insect gustatory and odorant receptors (GRs and ORs) form a superfamily of novel transmembrane proteins, which are expressed in chemosensory neurons that detect environmental stimuli. Here we identify homologues of GRs (Gustatory receptor-like (Grl) genes) in genomes across Protostomia, Deuterostomia and non-Bilateria. Surprisingly, two Grls in the cnidarian Nematostella vectensis, NvecGrl1 and NvecGrl2, are expressed early in development, in the blastula and gastrula, but not at later stages when a putative chemosensory organ forms. NvecGrl1 transcripts are detected around the aboral pole, considered the equivalent to the head-forming region of Bilateria. Morpholino-mediated knockdown of NvecGrl1 causes developmental patterning defects of this region, leading to animals lacking the apical sensory organ. A deuterostome Grl from the sea urchin Strongylocentrotus purpuratus displays similar patterns of developmental expression. These results reveal an early evolutionary origin of the insect chemosensory receptor family and raise the possibility that their ancestral role was in embryonic development.

PubMed ID: 25692633
PMC ID: PMC4374167
Article link: Nat Commun
Grant support: [+]

Genes referenced: LOC100887844 LOC105444438 LOC115925415 LOC590297 pole


Article Images: [+] show captions
References [+] :
Anisimova, Approximate likelihood-ratio test for branches: A fast, accurate, and powerful alternative. 2006, Pubmed