Collu GM , Hidalgo-Sastre A , Brennan K .

Aberle, beta-catenin is a target for the ubiquitin-proteasome pathway. 1997, Pubmed

Aberle, beta-catenin is a target for the ubiquitin-proteasome pathway. 1997, Pubmed
Acosta, Notch destabilises maternal beta-catenin and restricts dorsal-anterior development in Xenopus. 2011, Pubmed
Adler, The genetic control of tissue polarity in Drosophila. 1992, Pubmed
Amit, Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway. 2002, Pubmed
Amoyel, Wnt1 regulates neurogenesis and mediates lateral inhibition of boundary cell specification in the zebrafish hindbrain. 2005, Pubmed
Arcaroli, Tumours with elevated levels of the Notch and Wnt pathways exhibit efficacy to PF-03084014, a γ-secretase inhibitor, in a preclinical colorectal explant model. 2013, Pubmed
Arias, Filtering transcriptional noise during development: concepts and mechanisms. 2006, Pubmed
Axelrod, Interaction between Wingless and Notch signaling pathways mediated by dishevelled. 1996, Pubmed
Ayyanan, Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism. 2006, Pubmed
Baylies, wingless is required for the formation of a subset of muscle founder cells during Drosophila embryogenesis. 1995, Pubmed
Bernard, Specificity of Notch pathway activation: twist controls the transcriptional output in adult muscle progenitors. 2010, Pubmed
Blokzijl, Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3. 2003, Pubmed
Bolós, Notch signaling in development and cancer. 2007, Pubmed
Boulter, Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. 2012, Pubmed
Bouras, Notch signaling regulates mammary stem cell function and luminal cell-fate commitment. 2008, Pubmed
Brack, A temporal switch from notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis. 2008, Pubmed
Brannon, A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus. 1997, Pubmed
Brennan, Wingless modulates the effects of dominant negative notch molecules in the developing wing of Drosophila. 1999, Pubmed
Brennan, A functional analysis of Notch mutations in Drosophila. 1997, Pubmed
Buceta, Robustness and stability of the gene regulatory network involved in DV boundary formation in the Drosophila wing. 2007, Pubmed
Capilla, Planar cell polarity controls directional Notch signaling in the Drosophila leg. 2012, Pubmed
Cavallo, Drosophila Tcf and Groucho interact to repress Wingless signalling activity. 1998, Pubmed
Chen, Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. 2009, Pubmed
Cheng, Notch activation regulates the segregation and differentiation of rhombomere boundary cells in the zebrafish hindbrain. 2004, Pubmed
Clayton, A single type of progenitor cell maintains normal epidermis. 2007, Pubmed
Clevers, Wnt/beta-catenin signaling in development and disease. 2006, Pubmed
Clevers, The intestinal crypt, a prototype stem cell compartment. 2013, Pubmed
Collu, Dishevelled limits Notch signalling through inhibition of CSL. 2012, Pubmed
Collu, Cooperation between Wnt and Notch signalling in human breast cancer. 2007, Pubmed
Couso, Notch is required for wingless signaling in the epidermis of Drosophila. 1994, Pubmed
Cubas, Proneural clusters of achaete-scute expression and the generation of sensory organs in the Drosophila imaginal wing disc. 1991, Pubmed
Dahlqvist, Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation. 2003, Pubmed
Daniels, Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation. 2005, Pubmed
Deblandre, A two-step mechanism generates the spacing pattern of the ciliated cells in the skin of Xenopus embryos. 1999, Pubmed
Dequéant, A complex oscillating network of signaling genes underlies the mouse segmentation clock. 2006, Pubmed
Deregowski, Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/beta-catenin but not bone morphogenetic protein signaling. 2006, Pubmed
Doupé, The ordered architecture of murine ear epidermis is maintained by progenitor cells with random fate. 2010, Pubmed
Ehebauer, High-resolution crystal structure of the human Notch 1 ankyrin domain. 2005, Pubmed
Espinosa, Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways. 2003, Pubmed
Fischer, Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors. 2007, Pubmed
Foltz, Glycogen synthase kinase-3beta modulates notch signaling and stability. 2002, Pubmed
Fre, Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine. 2009, Pubmed
Galceran, LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis. 2004, Pubmed
Gonsalves, An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. 2011, Pubmed
Gu, Chromatin effector Pygo2 mediates Wnt-notch crosstalk to suppress luminal/alveolar potential of mammary stem and basal cells. 2013, Pubmed
Hart, Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. 1998, Pubmed
Hayward, Wnt/Notch signalling and information processing during development. 2008, Pubmed
Hayward, Notch modulates Wnt signalling by associating with Armadillo/beta-catenin and regulating its transcriptional activity. 2005, Pubmed
He, Identification of c-MYC as a target of the APC pathway. 1998, Pubmed
Heath, Transcriptional networks and signaling pathways that govern vertebrate intestinal development. 2010, Pubmed
Heitzler, The choice of cell fate in the epidermis of Drosophila. 1991, Pubmed
Heuberger, Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling. 2010, Pubmed
Hurlbut, Crossing paths with Notch in the hyper-network. 2007, Pubmed
Iso, HES and HERP families: multiple effectors of the Notch signaling pathway. 2003, Pubmed
Jayasena, Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode. 2008, Pubmed
Jeffries, Characterization of a high-molecular-weight Notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line. 2002, Pubmed
Jehn, c-Cbl binding and ubiquitin-dependent lysosomal degradation of membrane-associated Notch1. 2002, Pubmed
Jho, Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. 2002, Pubmed
Jin, Beta-catenin modulates the level and transcriptional activity of Notch1/NICD through its direct interaction. 2009, Pubmed
Joshi, Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases. 2009, Pubmed
Kim, Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer. 2012, Pubmed
Kishida, Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin. 1998, Pubmed
Klein, Different spatial and temporal interactions between Notch, wingless, and vestigial specify proximal and distal pattern elements of the wing in Drosophila. 1998, Pubmed
Klein, The vestigial gene product provides a molecular context for the interpretation of signals during the development of the wing in Drosophila. 1999, Pubmed
Klinakis, Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice. 2006, Pubmed
Kovall, Mechanistic insights into Notch receptor signaling from structural and biochemical studies. 2010, Pubmed
Kramps, Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. 2002, Pubmed
Kwon, Notch post-translationally regulates β-catenin protein in stem and progenitor cells. 2011, Pubmed
Kwon, A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. 2009, Pubmed
Kühl, The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape. 2000, Pubmed
Latres, The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin. 1999, Pubmed
Lawrence, Notch signaling targets the Wingless responsiveness of a Ubx visceral mesoderm enhancer in Drosophila. 2001, Pubmed
Li, Shaping organs by a wingless-int/Notch/nonmuscle myosin module which orients feather bud elongation. 2013, Pubmed
Lim, Interfollicular epidermal stem cells self-renew via autocrine Wnt signaling. 2013, Pubmed
Lin, Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells. 2008, Pubmed
Liu, Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. 2002, Pubmed
Lopez-Garcia, Intestinal stem cell replacement follows a pattern of neutral drift. 2010, Pubmed
Lowell, Notch promotes neural lineage entry by pluripotent embryonic stem cells. 2006, Pubmed
Lowell, Stimulation of human epidermal differentiation by delta-notch signalling at the boundaries of stem-cell clusters. 2000, Pubmed
McGill, Numb regulates post-endocytic trafficking and degradation of Notch1. 2009, Pubmed
Micchelli, Dorsoventral lineage restriction in wing imaginal discs requires Notch. 1999, Pubmed
Micchelli, The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate. 1997, Pubmed
Molenaar, XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos. 1996, Pubmed
Muñoz-Descalzo, Wingless modulates the ligand independent traffic of Notch through Dishevelled. 2010, Pubmed
Nichols, DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur. 2007, Pubmed
Ohlstein, Multipotent Drosophila intestinal stem cells specify daughter cell fates by differential notch signaling. 2007, Pubmed
Palomero, NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. 2006, Pubmed
Parker, Pygopus, a nuclear PHD-finger protein required for Wingless signaling in Drosophila. 2002, Pubmed
Parks, Delta function is required for bristle organ determination and morphogenesis in Drosophila. 1993, Pubmed
Pasternak, Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane. 2003, Pubmed
Peifer, The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties. 1992, Pubmed
Peter, A gene regulatory network controlling the embryonic specification of endoderm. 2011, Pubmed , Echinobase
Pires-daSilva, The evolution of signalling pathways in animal development. 2003, Pubmed
Ramain, Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate. 2001, Pubmed
Rangarajan, Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. 2001, Pubmed
Rebay, Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor. 1991, Pubmed
Reya, Wnt signalling in stem cells and cancer. 2005, Pubmed
Riley, Rhombomere boundaries are Wnt signaling centers that regulate metameric patterning in the zebrafish hindbrain. 2004, Pubmed
Rios, Neural crest regulates myogenesis through the transient activation of NOTCH. 2011, Pubmed
Rodilla, Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer. 2009, Pubmed
Ronchini, Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic). 2001, Pubmed
Ross, The notch intracellular domain can function as a coactivator for LEF-1. 2001, Pubmed
Rulifson, Notch regulates wingless expression and is not required for reception of the paracrine wingless signal during wing margin neurogenesis in Drosophila. 1995, Pubmed
Rulifson, wingless refines its own expression domain on the Drosophila wing margin. 1996, Pubmed
Sanchez-Irizarry, Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats. 2004, Pubmed
Sanders, Ligand-independent traffic of Notch buffers activated Armadillo in Drosophila. 2009, Pubmed
Shimizu, Stabilized beta-catenin functions through TCF/LEF proteins and the Notch/RBP-Jkappa complex to promote proliferation and suppress differentiation of neural precursor cells. 2008, Pubmed
Skeath, Regulation of achaete-scute gene expression and sensory organ pattern formation in the Drosophila wing. 1991, Pubmed
Snippert, Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. 2010, Pubmed
Spee, Characterisation of the liver progenitor cell niche in liver diseases: potential involvement of Wnt and Notch signalling. 2010, Pubmed
Strutt, Asymmetric localization of frizzled and the determination of notch-dependent cell fate in the Drosophila eye. 2002, Pubmed
Tamura, Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H). 1995, Pubmed
Terriente-Felix, Notch cooperates with Lozenge/Runx to lock haemocytes into a differentiation programme. 2013, Pubmed
Thompson, A new nuclear component of the Wnt signalling pathway. 2002, Pubmed
Tolwinski, Rethinking WNT signaling. 2004, Pubmed
Tolwinski, A nuclear function for armadillo/beta-catenin. 2004, Pubmed
Trowbridge, Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation. 2006, Pubmed
Vinson, Directional non-cell autonomy and the transmission of polarity information by the frizzled gene of Drosophila. 1987, Pubmed
Wang, Human Notch-1 inhibits NF-kappa B activity in the nucleus through a direct interaction involving a novel domain. 2001, Pubmed
Weng, c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. 2006, Pubmed
Wesley, Notch and wingless regulate expression of cuticle patterning genes. 1999, Pubmed
Yalcin-Ozuysal, Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates. 2010, Pubmed
Yamamizu, Convergence of Notch and beta-catenin signaling induces arterial fate in vascular progenitors. 2010, Pubmed
Yanagawa, Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila. 2002, Pubmed
Yeh, PAPTi: a peptide aptamer interference toolkit for perturbation of protein-protein interaction networks. 2013, Pubmed
Yin, Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny. 2014, Pubmed
Yost, The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. 1996, Pubmed
Young, Diverse roles for the Notch receptor in the development of D. melanogaster. 1997, Pubmed
Zeng, Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture. 2010, Pubmed
Zhou, Notch and wingless signaling cooperate in regulation of dendritic cell differentiation. 2009, Pubmed
de Celis, Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc. 1996, Pubmed
de Navascués, Drosophila midgut homeostasis involves neutral competition between symmetrically dividing intestinal stem cells. 2012, Pubmed
del Alamo, Frizzled/PCP-dependent asymmetric neuralized expression determines R3/R4 fates in the Drosophila eye. 2006, Pubmed
van Amerongen, Developmental stage and time dictate the fate of Wnt/β-catenin-responsive stem cells in the mammary gland. 2012, Pubmed
van Amerongen, Towards an integrated view of Wnt signaling in development. 2009, Pubmed
van Es, Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. 2005, Pubmed
van Es, Wnt signalling induces maturation of Paneth cells in intestinal crypts. 2005, Pubmed
van Es, Dll1+ secretory progenitor cells revert to stem cells upon crypt damage. 2012, Pubmed
van de Wetering, Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. 1997, Pubmed