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Curr Opin Cell Biol 2010 Feb 01;221:96-103. doi: 10.1016/
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Microtubule-severing enzymes.

Roll-Mecak A , McNally FJ .

In 1993, an enzyme with an ATP-dependent microtubule-severing activity was purified from sea urchin eggs and named katanin, after the Japanese word for sword. Now we know that katanin, spastin, and fidgetin form a family of closely related microtubule-severing enzymes that is widely distributed in eukaryotes ranging from Tetrahymena and Chlamydomonas to humans. Here we review the diverse in vivo functions of these proteins and the recent significant advances in deciphering the biophysical mechanism of microtubule severing.

PubMed ID: 19963362
PMC ID: PMC2822099
Article link: Curr Opin Cell Biol
Grant support: [+]

Genes referenced: ift52 LOC100887844 spast

References [+] :
Ahmad, An essential role for katanin in severing microtubules in the neuron. 1999, Pubmed