ECB-ART-39944Mol Biol Cell 2006 Dec 01;1712:5241-52. doi: 10.1091/mbc.e06-07-0634.
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Rendezvin: An essential gene encoding independent, differentially secreted egg proteins that organize the fertilization envelope proteome after self-association.
Preventing polyspermy during animal fertilization relies on modifications to the egg''s extracellular matrix. On fertilization in sea urchins, the contents of cortical granules are secreted and rapidly assemble into the egg''s extracellular vitelline layer, forming the fertilization envelope, a proteinaceous structure that protects the zygote from subsequent sperm. Here, we document rendezvin, a gene whose transcript is differentially spliced to yield proteins destined for either cortical granules or the vitelline layer. These distinctly trafficked variants reunite after cortical granule secretion at fertilization. Together, they help coordinate assembly of the functional fertilization envelope, whose proteome is now defined in full.
PubMed ID: 17005910
PMC ID: PMC1679687
Article link: Mol Biol Cell
Genes referenced: LOC100887844
Antibodies: mgb Ab1 mgb Ab2 mgb Ab3 mgb Ab4
References [+] :
Andersen, Identification of the minimal functional unit in the low density lipoprotein receptor-related protein for binding the receptor-associated protein (RAP). A conserved acidic residue in the complement-type repeats is important for recognition of RAP. 2000, Pubmed